Effect of prolactin and estrogen on the serum level of 1,25-dihydroxy vitamin D and FGF23 in female rats
Introduction Estrogen and prolactin affect vitamin D metabolism. In conditions such as pregnancy and lactation, their interaction in regulating vitamin D metabolism and circulating FGF23 is not clearly defined. The aim of this study is to investigate this interaction in female rats. Method This stud...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2020-07, Vol.302 (1), p.265-271 |
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| description | Introduction
Estrogen and prolactin affect vitamin D metabolism. In conditions such as pregnancy and lactation, their interaction in regulating vitamin D metabolism and circulating FGF23 is not clearly defined. The aim of this study is to investigate this interaction in female rats.
Method
This study was performed on 50 female adult rats, which were divided into five groups of Sham, ovariectomized rats (O), and three groups of ovariectomized rats were indicated with prolactin alone (OP), estradiol alone (OE), and a combination of estradiol and prolactin (OEP). Serum levels of 25(OH)D, 1,25(OH)2D3, FGF23, PTH, vitamin D-binding protein, calcium, and phosphorous were evaluated.
Results
Serum 1,25(OH)2D3 and PTH in OE were higher than the O group (
P
|
| doi_str_mv | 10.1007/s00404-020-05567-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2404042782</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2408733010</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-44dc3f47dcd1e9e538d30790dae064d93c8b18fc4c1185a9c8ce5bf4ffb325863</originalsourceid><addsrcrecordid>eNp9kTtP7DAQhS0EguXxByiuLNFQEBg_kjglAhaQkGigtrz2mA3Kg2sniP33OCwPiQK5sC1_c2aODyGHDE4ZQHkWASTIDDhkkOdFmRUbZMak4BmUjG2SGVTTGYpyh-zG-AzAuFLFNtkRXEJVcTkjyyvv0Q609_Ql9I2xQ91R0zmKcQj9E3a07-iwRBoxjC1t8BWbCWYnPM9cvVy50L-t6Gs9mDZVXn7Uzq_nXNB09diaBmkwQ9wnW940EQ8-9z3yOL96uLjJ7u6vby_O7zIrJRsyKZ0VXpbOOoYV5kI5AWUFziAU0lXCqgVT3krLmMpNZZXFfOGl9wvBc1WIPXK81k12_o_JhW7raLFpTIf9GHVynhYvFU_o0S_0uR9Dl6abKFUKAQwSxdeUDX2MAb1-CXVrwkoz0FMOep2DTjnojxz0NMW_T-lx0aL7Lvn6-ASINRDTU_eE4af3H7Lv0OyRBQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2408733010</pqid></control><display><type>article</type><title>Effect of prolactin and estrogen on the serum level of 1,25-dihydroxy vitamin D and FGF23 in female rats</title><source>SpringerLink Journals - AutoHoldings</source><creator>Saki, Forough ; Sadeghian, Faezeh ; Kasaee, Seyed Reza ; Koohpeyma, Farhad ; Ranjbar Omrani, Gholam Hossein</creator><creatorcontrib>Saki, Forough ; Sadeghian, Faezeh ; Kasaee, Seyed Reza ; Koohpeyma, Farhad ; Ranjbar Omrani, Gholam Hossein</creatorcontrib><description>Introduction
Estrogen and prolactin affect vitamin D metabolism. In conditions such as pregnancy and lactation, their interaction in regulating vitamin D metabolism and circulating FGF23 is not clearly defined. The aim of this study is to investigate this interaction in female rats.
Method
This study was performed on 50 female adult rats, which were divided into five groups of Sham, ovariectomized rats (O), and three groups of ovariectomized rats were indicated with prolactin alone (OP), estradiol alone (OE), and a combination of estradiol and prolactin (OEP). Serum levels of 25(OH)D, 1,25(OH)2D3, FGF23, PTH, vitamin D-binding protein, calcium, and phosphorous were evaluated.
Results
Serum 1,25(OH)2D3 and PTH in OE were higher than the O group (
P
< 0.001 and
P
= 0.003, respectively). Serum FGF23 in the OE group was lower than the O group (
P
= 0.016). Serum 1,25(OH)2D3 increased in OP compared to the O group (
P
< 0.001) and OE group (
P
< 0.001). Serum FGF23 in OP was lower than the O group (
P
= 0.04). Furthermore, combining estradiol and prolactin showed no extra effect on increasing serum 1,25(OH)2D3. Serum 1,25(OH)2D3 was positively correlated with serum prolactin levels (
r
= 0.318,
P
= 0.017) in all five groups.
Conclusion
It is suggested that estradiol could increase 1,25(OH)2D3 by elevating PTH and decreasing serum FGF23; however, prolactin was able to increase 1,25(OH)2D3 by lowering serum FGF23. Moreover, prolactin was shown to be more potent in augmenting serum 1,25(OH)2D3 than estrogen itself, which is important in maternal and fetal calcium supply during late pregnancy and lactation.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-020-05567-6</identifier><identifier>PMID: 32409924</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Breastfeeding & lactation ; Endocrinology ; Gynecologic Endocrinology and Reproductive Medicine ; Gynecology ; Human Genetics ; Medicine ; Medicine & Public Health ; Metabolism ; Obstetrics/Perinatology/Midwifery ; Rodents ; Vitamin D</subject><ispartof>Archives of gynecology and obstetrics, 2020-07, Vol.302 (1), p.265-271</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-44dc3f47dcd1e9e538d30790dae064d93c8b18fc4c1185a9c8ce5bf4ffb325863</citedby><cites>FETCH-LOGICAL-c441t-44dc3f47dcd1e9e538d30790dae064d93c8b18fc4c1185a9c8ce5bf4ffb325863</cites><orcidid>0000-0003-1900-5242 ; 0000-0003-2224-7250</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-020-05567-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-020-05567-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32409924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saki, Forough</creatorcontrib><creatorcontrib>Sadeghian, Faezeh</creatorcontrib><creatorcontrib>Kasaee, Seyed Reza</creatorcontrib><creatorcontrib>Koohpeyma, Farhad</creatorcontrib><creatorcontrib>Ranjbar Omrani, Gholam Hossein</creatorcontrib><title>Effect of prolactin and estrogen on the serum level of 1,25-dihydroxy vitamin D and FGF23 in female rats</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Introduction
Estrogen and prolactin affect vitamin D metabolism. In conditions such as pregnancy and lactation, their interaction in regulating vitamin D metabolism and circulating FGF23 is not clearly defined. The aim of this study is to investigate this interaction in female rats.
Method
This study was performed on 50 female adult rats, which were divided into five groups of Sham, ovariectomized rats (O), and three groups of ovariectomized rats were indicated with prolactin alone (OP), estradiol alone (OE), and a combination of estradiol and prolactin (OEP). Serum levels of 25(OH)D, 1,25(OH)2D3, FGF23, PTH, vitamin D-binding protein, calcium, and phosphorous were evaluated.
Results
Serum 1,25(OH)2D3 and PTH in OE were higher than the O group (
P
< 0.001 and
P
= 0.003, respectively). Serum FGF23 in the OE group was lower than the O group (
P
= 0.016). Serum 1,25(OH)2D3 increased in OP compared to the O group (
P
< 0.001) and OE group (
P
< 0.001). Serum FGF23 in OP was lower than the O group (
P
= 0.04). Furthermore, combining estradiol and prolactin showed no extra effect on increasing serum 1,25(OH)2D3. Serum 1,25(OH)2D3 was positively correlated with serum prolactin levels (
r
= 0.318,
P
= 0.017) in all five groups.
Conclusion
It is suggested that estradiol could increase 1,25(OH)2D3 by elevating PTH and decreasing serum FGF23; however, prolactin was able to increase 1,25(OH)2D3 by lowering serum FGF23. Moreover, prolactin was shown to be more potent in augmenting serum 1,25(OH)2D3 than estrogen itself, which is important in maternal and fetal calcium supply during late pregnancy and lactation.</description><subject>Breastfeeding & lactation</subject><subject>Endocrinology</subject><subject>Gynecologic Endocrinology and Reproductive Medicine</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Rodents</subject><subject>Vitamin D</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kTtP7DAQhS0EguXxByiuLNFQEBg_kjglAhaQkGigtrz2mA3Kg2sniP33OCwPiQK5sC1_c2aODyGHDE4ZQHkWASTIDDhkkOdFmRUbZMak4BmUjG2SGVTTGYpyh-zG-AzAuFLFNtkRXEJVcTkjyyvv0Q609_Ql9I2xQ91R0zmKcQj9E3a07-iwRBoxjC1t8BWbCWYnPM9cvVy50L-t6Gs9mDZVXn7Uzq_nXNB09diaBmkwQ9wnW940EQ8-9z3yOL96uLjJ7u6vby_O7zIrJRsyKZ0VXpbOOoYV5kI5AWUFziAU0lXCqgVT3krLmMpNZZXFfOGl9wvBc1WIPXK81k12_o_JhW7raLFpTIf9GHVynhYvFU_o0S_0uR9Dl6abKFUKAQwSxdeUDX2MAb1-CXVrwkoz0FMOep2DTjnojxz0NMW_T-lx0aL7Lvn6-ASINRDTU_eE4af3H7Lv0OyRBQ</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Saki, Forough</creator><creator>Sadeghian, Faezeh</creator><creator>Kasaee, Seyed Reza</creator><creator>Koohpeyma, Farhad</creator><creator>Ranjbar Omrani, Gholam Hossein</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1900-5242</orcidid><orcidid>https://orcid.org/0000-0003-2224-7250</orcidid></search><sort><creationdate>20200701</creationdate><title>Effect of prolactin and estrogen on the serum level of 1,25-dihydroxy vitamin D and FGF23 in female rats</title><author>Saki, Forough ; Sadeghian, Faezeh ; Kasaee, Seyed Reza ; Koohpeyma, Farhad ; Ranjbar Omrani, Gholam Hossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-44dc3f47dcd1e9e538d30790dae064d93c8b18fc4c1185a9c8ce5bf4ffb325863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Breastfeeding & lactation</topic><topic>Endocrinology</topic><topic>Gynecologic Endocrinology and Reproductive Medicine</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Rodents</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saki, Forough</creatorcontrib><creatorcontrib>Sadeghian, Faezeh</creatorcontrib><creatorcontrib>Kasaee, Seyed Reza</creatorcontrib><creatorcontrib>Koohpeyma, Farhad</creatorcontrib><creatorcontrib>Ranjbar Omrani, Gholam Hossein</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saki, Forough</au><au>Sadeghian, Faezeh</au><au>Kasaee, Seyed Reza</au><au>Koohpeyma, Farhad</au><au>Ranjbar Omrani, Gholam Hossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of prolactin and estrogen on the serum level of 1,25-dihydroxy vitamin D and FGF23 in female rats</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>302</volume><issue>1</issue><spage>265</spage><epage>271</epage><pages>265-271</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Introduction
Estrogen and prolactin affect vitamin D metabolism. In conditions such as pregnancy and lactation, their interaction in regulating vitamin D metabolism and circulating FGF23 is not clearly defined. The aim of this study is to investigate this interaction in female rats.
Method
This study was performed on 50 female adult rats, which were divided into five groups of Sham, ovariectomized rats (O), and three groups of ovariectomized rats were indicated with prolactin alone (OP), estradiol alone (OE), and a combination of estradiol and prolactin (OEP). Serum levels of 25(OH)D, 1,25(OH)2D3, FGF23, PTH, vitamin D-binding protein, calcium, and phosphorous were evaluated.
Results
Serum 1,25(OH)2D3 and PTH in OE were higher than the O group (
P
< 0.001 and
P
= 0.003, respectively). Serum FGF23 in the OE group was lower than the O group (
P
= 0.016). Serum 1,25(OH)2D3 increased in OP compared to the O group (
P
< 0.001) and OE group (
P
< 0.001). Serum FGF23 in OP was lower than the O group (
P
= 0.04). Furthermore, combining estradiol and prolactin showed no extra effect on increasing serum 1,25(OH)2D3. Serum 1,25(OH)2D3 was positively correlated with serum prolactin levels (
r
= 0.318,
P
= 0.017) in all five groups.
Conclusion
It is suggested that estradiol could increase 1,25(OH)2D3 by elevating PTH and decreasing serum FGF23; however, prolactin was able to increase 1,25(OH)2D3 by lowering serum FGF23. Moreover, prolactin was shown to be more potent in augmenting serum 1,25(OH)2D3 than estrogen itself, which is important in maternal and fetal calcium supply during late pregnancy and lactation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32409924</pmid><doi>10.1007/s00404-020-05567-6</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1900-5242</orcidid><orcidid>https://orcid.org/0000-0003-2224-7250</orcidid></addata></record> |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Breastfeeding & lactation Endocrinology Gynecologic Endocrinology and Reproductive Medicine Gynecology Human Genetics Medicine Medicine & Public Health Metabolism Obstetrics/Perinatology/Midwifery Rodents Vitamin D |
| title | Effect of prolactin and estrogen on the serum level of 1,25-dihydroxy vitamin D and FGF23 in female rats |
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