A review on fucoidan antitumor strategies: From a biological active agent to a structural component of fucoidan-based systems
•Fucoidan is a sulfated polysaccharide with different biological activities.•Its antitumor potential has been mainly studied as a soluble bioactive agent.•Chemical features influence the mechanisms of action and efficacy of antitumor approaches.•In recent years, fucoidan-based systems, namely for dr...
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| Veröffentlicht in: | Carbohydrate polymers 2020-07, Vol.239, p.116131-116131, Article 116131 |
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| creator | Oliveira, Catarina Neves, Nuno M. Reis, Rui L. Martins, Albino Silva, Tiago H. |
| description | •Fucoidan is a sulfated polysaccharide with different biological activities.•Its antitumor potential has been mainly studied as a soluble bioactive agent.•Chemical features influence the mechanisms of action and efficacy of antitumor approaches.•In recent years, fucoidan-based systems, namely for drug delivery have been developed.
Due to the severe side-effects and the toxicity to healthy tissues, cancer treatments based in chemotherapy have not fully achieved the desire outcomes so far. The use of natural compound may be of great value to develop better tolerated therapies. Fucoidan is a marine sulfated polysaccharide extracted from brown algae that, besides other biological activities, has been reported to present interesting anti-cancer potential. This review briefly introduces fucoidan chemical structure, physicochemical properties and the above-mentioned biological feature. Fucoidan usage as soluble agent presents promising results herein described for different types of cancer. Trying to enhance and optimize fucoidan usage in the cancer field, different systems, namely drug delivery, have been recently developed to target different types of cancers. This aspect will be presented in detail, highlighting the role of fucoidan on their reported or envisaged performance. |
| doi_str_mv | 10.1016/j.carbpol.2020.116131 |
| format | Article |
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Due to the severe side-effects and the toxicity to healthy tissues, cancer treatments based in chemotherapy have not fully achieved the desire outcomes so far. The use of natural compound may be of great value to develop better tolerated therapies. Fucoidan is a marine sulfated polysaccharide extracted from brown algae that, besides other biological activities, has been reported to present interesting anti-cancer potential. This review briefly introduces fucoidan chemical structure, physicochemical properties and the above-mentioned biological feature. Fucoidan usage as soluble agent presents promising results herein described for different types of cancer. Trying to enhance and optimize fucoidan usage in the cancer field, different systems, namely drug delivery, have been recently developed to target different types of cancers. This aspect will be presented in detail, highlighting the role of fucoidan on their reported or envisaged performance.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2020.116131</identifier><identifier>PMID: 32414455</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - therapeutic use ; Antitumor ; Biological Factors - chemistry ; Biological Factors - isolation & purification ; Biological Factors - therapeutic use ; Compound ; Fucoidan ; Humans ; Neoplasms - drug therapy ; Phaeophyceae - chemistry ; Polysaccharides - chemistry ; Polysaccharides - isolation & purification ; Polysaccharides - therapeutic use ; Science & Technology ; Systems</subject><ispartof>Carbohydrate polymers, 2020-07, Vol.239, p.116131-116131, Article 116131</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-bacae8de481bdc59fa6a7e0968028ef2e897bc0281fbfcc0b9e87e8fdb1e911c3</citedby><cites>FETCH-LOGICAL-c437t-bacae8de481bdc59fa6a7e0968028ef2e897bc0281fbfcc0b9e87e8fdb1e911c3</cites><orcidid>0000-0001-8520-603X ; 0000-0002-4014-6472 ; 0000-0003-3868-0251</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carbpol.2020.116131$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32414455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oliveira, Catarina</creatorcontrib><creatorcontrib>Neves, Nuno M.</creatorcontrib><creatorcontrib>Reis, Rui L.</creatorcontrib><creatorcontrib>Martins, Albino</creatorcontrib><creatorcontrib>Silva, Tiago H.</creatorcontrib><title>A review on fucoidan antitumor strategies: From a biological active agent to a structural component of fucoidan-based systems</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>•Fucoidan is a sulfated polysaccharide with different biological activities.•Its antitumor potential has been mainly studied as a soluble bioactive agent.•Chemical features influence the mechanisms of action and efficacy of antitumor approaches.•In recent years, fucoidan-based systems, namely for drug delivery have been developed.
Due to the severe side-effects and the toxicity to healthy tissues, cancer treatments based in chemotherapy have not fully achieved the desire outcomes so far. The use of natural compound may be of great value to develop better tolerated therapies. Fucoidan is a marine sulfated polysaccharide extracted from brown algae that, besides other biological activities, has been reported to present interesting anti-cancer potential. This review briefly introduces fucoidan chemical structure, physicochemical properties and the above-mentioned biological feature. Fucoidan usage as soluble agent presents promising results herein described for different types of cancer. Trying to enhance and optimize fucoidan usage in the cancer field, different systems, namely drug delivery, have been recently developed to target different types of cancers. 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Due to the severe side-effects and the toxicity to healthy tissues, cancer treatments based in chemotherapy have not fully achieved the desire outcomes so far. The use of natural compound may be of great value to develop better tolerated therapies. Fucoidan is a marine sulfated polysaccharide extracted from brown algae that, besides other biological activities, has been reported to present interesting anti-cancer potential. This review briefly introduces fucoidan chemical structure, physicochemical properties and the above-mentioned biological feature. Fucoidan usage as soluble agent presents promising results herein described for different types of cancer. Trying to enhance and optimize fucoidan usage in the cancer field, different systems, namely drug delivery, have been recently developed to target different types of cancers. This aspect will be presented in detail, highlighting the role of fucoidan on their reported or envisaged performance.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>32414455</pmid><doi>10.1016/j.carbpol.2020.116131</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-8520-603X</orcidid><orcidid>https://orcid.org/0000-0002-4014-6472</orcidid><orcidid>https://orcid.org/0000-0003-3868-0251</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - therapeutic use Antitumor Biological Factors - chemistry Biological Factors - isolation & purification Biological Factors - therapeutic use Compound Fucoidan Humans Neoplasms - drug therapy Phaeophyceae - chemistry Polysaccharides - chemistry Polysaccharides - isolation & purification Polysaccharides - therapeutic use Science & Technology Systems |
| title | A review on fucoidan antitumor strategies: From a biological active agent to a structural component of fucoidan-based systems |
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