Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative Stress and Inflammation

Silent information regulator 1 ( SIRT1 ) is a ubiquitously expressed protein and has an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a NAD+-dependent deacetylase and regulates gene expression by histone deacetylation. Deletion of SIRT1 in the liver, pancr...

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Veröffentlicht in:	Inflammation 2020-10, Vol.43 (5), p.1589-1598
Hauptverfasser:	Singh, Vivek, Ubaid, Saba
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Deacetylation Diabetes mellitus Fatty liver Forkhead protein Gene deletion Gene expression Histones Homeobox Immunology Inflammation Interleukin 1 Internal Medicine Liver diseases NAD Neurodegenerative diseases NF-κB protein Oxidative stress Pancreas Pathology Pharmacology/Toxicology Reactive oxygen species Review Rheumatology SIRT1 protein Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors
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