Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative Stress and Inflammation
Silent information regulator 1 ( SIRT1 ) is a ubiquitously expressed protein and has an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a NAD+-dependent deacetylase and regulates gene expression by histone deacetylation. Deletion of SIRT1 in the liver, pancr...
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| Veröffentlicht in: | Inflammation 2020-10, Vol.43 (5), p.1589-1598 |
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| creator | Singh, Vivek Ubaid, Saba |
| description | Silent information regulator 1
(
SIRT1
) is a ubiquitously expressed protein and has an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a NAD+-dependent deacetylase and regulates gene expression by histone deacetylation. Deletion of SIRT1 in the liver, pancreas, and brain significantly increases the reactive oxygen species (ROS) and inflammatory response. Literature survey on SIRT1 shows the evidence for its role in preventing oxidative stress and inflammation. Oxidative stress and inflammation are closely related pathophysiological processes and are involved in the pathogenesis of a number of chronic disorders such as fatty liver diseases, diabetes, and neurodegenerative diseases. Both oxidative stress and inflammation alter the expression of several genes such as
nuclear factor E2 related factor
(
Nrf2
),
nuclear factor E2 related factor 2
(
Nef2
),
nuclear factor kappa B
(
NF-kB
),
pancreatic and duodenal homeobox factor 1
(
PDX1
),
interleukin-1
(
IL1
),
forkhead box class O
(
FOXO
), and
tumour necrosis factor alpha
(
TNF-α
). By annotating this knowledge, we can conclude that modulating the expression of SIRT1 might prevent the onset of diseases inexorably linked to the liver, pancreas, and brain.
Graphical Abstract
Role of silent information regulator 1 (SIRT1) in the pancreas, brain, and liver |
| doi_str_mv | 10.1007/s10753-020-01242-9 |
| format | Article |
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(
SIRT1
) is a ubiquitously expressed protein and has an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a NAD+-dependent deacetylase and regulates gene expression by histone deacetylation. Deletion of SIRT1 in the liver, pancreas, and brain significantly increases the reactive oxygen species (ROS) and inflammatory response. Literature survey on SIRT1 shows the evidence for its role in preventing oxidative stress and inflammation. Oxidative stress and inflammation are closely related pathophysiological processes and are involved in the pathogenesis of a number of chronic disorders such as fatty liver diseases, diabetes, and neurodegenerative diseases. Both oxidative stress and inflammation alter the expression of several genes such as
nuclear factor E2 related factor
(
Nrf2
),
nuclear factor E2 related factor 2
(
Nef2
),
nuclear factor kappa B
(
NF-kB
),
pancreatic and duodenal homeobox factor 1
(
PDX1
),
interleukin-1
(
IL1
),
forkhead box class O
(
FOXO
), and
tumour necrosis factor alpha
(
TNF-α
). By annotating this knowledge, we can conclude that modulating the expression of SIRT1 might prevent the onset of diseases inexorably linked to the liver, pancreas, and brain.
Graphical Abstract
Role of silent information regulator 1 (SIRT1) in the pancreas, brain, and liver</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/s10753-020-01242-9</identifier><identifier>PMID: 32410071</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Deacetylation ; Diabetes mellitus ; Fatty liver ; Forkhead protein ; Gene deletion ; Gene expression ; Histones ; Homeobox ; Immunology ; Inflammation ; Interleukin 1 ; Internal Medicine ; Liver diseases ; NAD ; Neurodegenerative diseases ; NF-κB protein ; Oxidative stress ; Pancreas ; Pathology ; Pharmacology/Toxicology ; Reactive oxygen species ; Review ; Rheumatology ; SIRT1 protein ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Tumors</subject><ispartof>Inflammation, 2020-10, Vol.43 (5), p.1589-1598</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-820f62df9e6589bf61e24d209c768497a574d175c89c2e51b717f59f81b907503</citedby><cites>FETCH-LOGICAL-c518t-820f62df9e6589bf61e24d209c768497a574d175c89c2e51b717f59f81b907503</cites><orcidid>0000-0002-8925-5039</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10753-020-01242-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10753-020-01242-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32410071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Vivek</creatorcontrib><creatorcontrib>Ubaid, Saba</creatorcontrib><title>Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative Stress and Inflammation</title><title>Inflammation</title><addtitle>Inflammation</addtitle><addtitle>Inflammation</addtitle><description>Silent information regulator 1
(
SIRT1
) is a ubiquitously expressed protein and has an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a NAD+-dependent deacetylase and regulates gene expression by histone deacetylation. Deletion of SIRT1 in the liver, pancreas, and brain significantly increases the reactive oxygen species (ROS) and inflammatory response. Literature survey on SIRT1 shows the evidence for its role in preventing oxidative stress and inflammation. Oxidative stress and inflammation are closely related pathophysiological processes and are involved in the pathogenesis of a number of chronic disorders such as fatty liver diseases, diabetes, and neurodegenerative diseases. Both oxidative stress and inflammation alter the expression of several genes such as
nuclear factor E2 related factor
(
Nrf2
),
nuclear factor E2 related factor 2
(
Nef2
),
nuclear factor kappa B
(
NF-kB
),
pancreatic and duodenal homeobox factor 1
(
PDX1
),
interleukin-1
(
IL1
),
forkhead box class O
(
FOXO
), and
tumour necrosis factor alpha
(
TNF-α
). By annotating this knowledge, we can conclude that modulating the expression of SIRT1 might prevent the onset of diseases inexorably linked to the liver, pancreas, and brain.
Graphical Abstract
Role of silent information regulator 1 (SIRT1) in the pancreas, brain, and liver</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Deacetylation</subject><subject>Diabetes mellitus</subject><subject>Fatty liver</subject><subject>Forkhead protein</subject><subject>Gene deletion</subject><subject>Gene expression</subject><subject>Histones</subject><subject>Homeobox</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Interleukin 1</subject><subject>Internal Medicine</subject><subject>Liver diseases</subject><subject>NAD</subject><subject>Neurodegenerative diseases</subject><subject>NF-κB protein</subject><subject>Oxidative stress</subject><subject>Pancreas</subject><subject>Pathology</subject><subject>Pharmacology/Toxicology</subject><subject>Reactive oxygen species</subject><subject>Review</subject><subject>Rheumatology</subject><subject>SIRT1 protein</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><subject>Tumors</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc9r2zAUx8XoWNNu_8AOQ9BLenD3nixZ0nGE_ggUCkl3nXBsKbjYVibZZfvvq9RtBjsEHSSkz_s88b6EfEW4QgD5PSJIkWfAIANknGX6A5mhkHnGhCxOyAzyArJca3lKzmJ8AgClVf6JnOaM7w04I79WvrXUO7puWtsPdNk7H7pyaHxPV3Y7tuXgA0U6Xy9Xj3hJm8N102_pw5-mTqdnS9dDsDHSsq_3irbsJsdn8tGVbbRf3vZz8vPm-nFxl90_3C4XP-6zSqAaMsXAFax22hZC6Y0r0DJeM9CVLBTXshSS1yhFpXTFrMCNROmEdgo3Os0A8nMyn7y74H-PNg6ma2Jl27bsrR-jYRzSYlzKhF78hz75MfTpd4YJUQguAOEoxTkIjkoUiWITVQUfY7DO7ELTleGvQTD7CZspI5MyMq8ZGZ2Kvr2px01n60PJeygJyCcgpqd-a8O_3ke0LxCtmHM</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Singh, Vivek</creator><creator>Ubaid, Saba</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8925-5039</orcidid></search><sort><creationdate>20201001</creationdate><title>Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative Stress and Inflammation</title><author>Singh, Vivek ; Ubaid, Saba</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-820f62df9e6589bf61e24d209c768497a574d175c89c2e51b717f59f81b907503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Deacetylation</topic><topic>Diabetes mellitus</topic><topic>Fatty liver</topic><topic>Forkhead protein</topic><topic>Gene deletion</topic><topic>Gene expression</topic><topic>Histones</topic><topic>Homeobox</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>Interleukin 1</topic><topic>Internal Medicine</topic><topic>Liver diseases</topic><topic>NAD</topic><topic>Neurodegenerative diseases</topic><topic>NF-κB protein</topic><topic>Oxidative stress</topic><topic>Pancreas</topic><topic>Pathology</topic><topic>Pharmacology/Toxicology</topic><topic>Reactive oxygen species</topic><topic>Review</topic><topic>Rheumatology</topic><topic>SIRT1 protein</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Vivek</creatorcontrib><creatorcontrib>Ubaid, Saba</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Vivek</au><au>Ubaid, Saba</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative Stress and Inflammation</atitle><jtitle>Inflammation</jtitle><stitle>Inflammation</stitle><addtitle>Inflammation</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>43</volume><issue>5</issue><spage>1589</spage><epage>1598</epage><pages>1589-1598</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><abstract>Silent information regulator 1
(
SIRT1
) is a ubiquitously expressed protein and has an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a NAD+-dependent deacetylase and regulates gene expression by histone deacetylation. Deletion of SIRT1 in the liver, pancreas, and brain significantly increases the reactive oxygen species (ROS) and inflammatory response. Literature survey on SIRT1 shows the evidence for its role in preventing oxidative stress and inflammation. Oxidative stress and inflammation are closely related pathophysiological processes and are involved in the pathogenesis of a number of chronic disorders such as fatty liver diseases, diabetes, and neurodegenerative diseases. Both oxidative stress and inflammation alter the expression of several genes such as
nuclear factor E2 related factor
(
Nrf2
),
nuclear factor E2 related factor 2
(
Nef2
),
nuclear factor kappa B
(
NF-kB
),
pancreatic and duodenal homeobox factor 1
(
PDX1
),
interleukin-1
(
IL1
),
forkhead box class O
(
FOXO
), and
tumour necrosis factor alpha
(
TNF-α
). By annotating this knowledge, we can conclude that modulating the expression of SIRT1 might prevent the onset of diseases inexorably linked to the liver, pancreas, and brain.
Graphical Abstract
Role of silent information regulator 1 (SIRT1) in the pancreas, brain, and liver</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32410071</pmid><doi>10.1007/s10753-020-01242-9</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8925-5039</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0360-3997 |
| ispartof | Inflammation, 2020-10, Vol.43 (5), p.1589-1598 |
| issn | 0360-3997 1573-2576 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Biomedical and Life Sciences Biomedicine Deacetylation Diabetes mellitus Fatty liver Forkhead protein Gene deletion Gene expression Histones Homeobox Immunology Inflammation Interleukin 1 Internal Medicine Liver diseases NAD Neurodegenerative diseases NF-κB protein Oxidative stress Pancreas Pathology Pharmacology/Toxicology Reactive oxygen species Review Rheumatology SIRT1 protein Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors |
| title | Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative Stress and Inflammation |
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