Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch–Schönlein purpura nephritis
Background To evaluate the apoptosis inhibitor of macrophage (AIM) deposition patterns on the kidneys of children with IgA nephropathy (IgAN) and Henoch–Schönlein purpura nephritis (HSPN) and to investigate the clinical usefulness of serum and/or urinary AIM levels as biomarkers for the disease acti...
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| Veröffentlicht in: | Pediatric research 2021-02, Vol.89 (3), p.667-672 |
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| creator | Irabu, Hitoshi Shimizu, Masaki Kaneko, Shuya Inoue, Natsumi Mizuta, Mao Tasaki, Yuko Ohta, Kazuhide Yachie, Akihiro Wada, Taizo |
| description | Background
To evaluate the apoptosis inhibitor of macrophage (AIM) deposition patterns on the kidneys of children with IgA nephropathy (IgAN) and Henoch–Schönlein purpura nephritis (HSPN) and to investigate the clinical usefulness of serum and/or urinary AIM levels as biomarkers for the disease activity.
Methods
Immunohistochemical study was performed in the kidneys of 37 patients with IgAN and 10 patients with HSPN. Serum and urinary AIM levels in the patients and 20 healthy controls (HCs) were quantified by enzyme-linked immunosorbent assay. The results were compared with clinical features.
Results
In patients with IgAN and HSPN, AIM expression was observed in various areas, including the glomerular mesangial and capillary areas, the proximal and distal tubular epithelial cells, and on infiltrating macrophages in the glomeruli and interstitial areas. Serum and urinary AIM levels were significantly elevated in these patients compared with the HCs. Urinary AIM levels were positively correlated with the histological severity and degree of proteinuria and hematuria as well as urinary β2 microglobulin and urinary
N
-acetyl-β-D-glucosaminidase levels.
Conclusions
AIM plays an important role in the pathogenesis of IgAN and HSPN. Urinary AIM levels can potentially reflect active renal inflammation in these diseases and may represent a useful biomarker for disease activity.
Impact
Urinary AIM levels may represent a useful biomarker for disease activity of IgAN and HSPN.
AIM expression was observed in the glomeruli, tubular epithelial cells, and infiltrating macrophages in glomeruli and interstitial area.
U-AIM/Cr were significantly correlated not only with proteinuria, hematuria, and u-β2MG and u-NAG levels but also with the activity index of histological findings in kidney biopsy specimens.
Our results can emphasize the important role of AIM in the pathogenesis of IgAN and HSPN. |
| doi_str_mv | 10.1038/s41390-020-0951-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2404039422</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2404039422</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-559e249dcf95b6a578e91b2ba8d99811e32612952e2567ef608a9ed490e65d053</originalsourceid><addsrcrecordid>eNp1kU1u1TAUhS0Eoo_CApggS0w6SfFvEg-fKkqLKjEAxpaT3Ly45NnBTorejD0wYiNsgJ2wEm6VFiQkJFuW7e8c-95DyHPOTjmT9ausuDSsYAKn0bzgD8iGa4k7paqHZMOY5IU0pj4iT3K-ZowrXavH5EgKxWqp2IZ8305xmmP2mfow-MbPMdHY071rU5wGtwPqMnW08XHv0idItEeg8xlcxqt29jd-PqCWvnWTC4CH7eDHLkGgX_w80MvdlgaYBnRz83CgLnT0AkJsh19fv71vh58_wggon5aEw62sn31-Sh71bszw7G49Jh_PX384uyiu3r25PNteFa2sxFxobUAo07W90U3pdFWD4Y1oXN1h4ZyDFCUXRgsQuqygL1ntDHTKMCh1x7Q8Jier75Ti5wXybPc-tzCOWE1cssVWKSaNEgLRl_-g13FJAX9nhWaSqUoohRRfKexgzgl6OyWPzTtYzuxtbnbNzWJu9jY3y1Hz4s55afbQ_VHcB4WAWIGMV2EH6e_T_3f9DZFEphk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2503047244</pqid></control><display><type>article</type><title>Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch–Schönlein purpura nephritis</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>SpringerLink Journals - AutoHoldings</source><creator>Irabu, Hitoshi ; Shimizu, Masaki ; Kaneko, Shuya ; Inoue, Natsumi ; Mizuta, Mao ; Tasaki, Yuko ; Ohta, Kazuhide ; Yachie, Akihiro ; Wada, Taizo</creator><creatorcontrib>Irabu, Hitoshi ; Shimizu, Masaki ; Kaneko, Shuya ; Inoue, Natsumi ; Mizuta, Mao ; Tasaki, Yuko ; Ohta, Kazuhide ; Yachie, Akihiro ; Wada, Taizo</creatorcontrib><description>Background
To evaluate the apoptosis inhibitor of macrophage (AIM) deposition patterns on the kidneys of children with IgA nephropathy (IgAN) and Henoch–Schönlein purpura nephritis (HSPN) and to investigate the clinical usefulness of serum and/or urinary AIM levels as biomarkers for the disease activity.
Methods
Immunohistochemical study was performed in the kidneys of 37 patients with IgAN and 10 patients with HSPN. Serum and urinary AIM levels in the patients and 20 healthy controls (HCs) were quantified by enzyme-linked immunosorbent assay. The results were compared with clinical features.
Results
In patients with IgAN and HSPN, AIM expression was observed in various areas, including the glomerular mesangial and capillary areas, the proximal and distal tubular epithelial cells, and on infiltrating macrophages in the glomeruli and interstitial areas. Serum and urinary AIM levels were significantly elevated in these patients compared with the HCs. Urinary AIM levels were positively correlated with the histological severity and degree of proteinuria and hematuria as well as urinary β2 microglobulin and urinary
N
-acetyl-β-D-glucosaminidase levels.
Conclusions
AIM plays an important role in the pathogenesis of IgAN and HSPN. Urinary AIM levels can potentially reflect active renal inflammation in these diseases and may represent a useful biomarker for disease activity.
Impact
Urinary AIM levels may represent a useful biomarker for disease activity of IgAN and HSPN.
AIM expression was observed in the glomeruli, tubular epithelial cells, and infiltrating macrophages in glomeruli and interstitial area.
U-AIM/Cr were significantly correlated not only with proteinuria, hematuria, and u-β2MG and u-NAG levels but also with the activity index of histological findings in kidney biopsy specimens.
Our results can emphasize the important role of AIM in the pathogenesis of IgAN and HSPN.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/s41390-020-0951-1</identifier><identifier>PMID: 32408340</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Adolescent ; Apoptosis ; Apoptosis Regulatory Proteins - biosynthesis ; Biomarkers ; Biomarkers - metabolism ; Biopsy ; Case-Control Studies ; Child ; Child, Preschool ; Clinical Research Article ; Disease ; Female ; Glomerulonephritis, IGA - genetics ; Glomerulonephritis, IGA - metabolism ; Hematuria ; Humans ; IgA Vasculitis - genetics ; IgA Vasculitis - metabolism ; Immunohistochemistry ; Inflammation ; Japan ; Kidney - pathology ; Kidney Glomerulus - metabolism ; Kidneys ; Leukocyte Count ; Macrophages - metabolism ; Male ; Medicine ; Medicine & Public Health ; Pathogenesis ; Pediatric Surgery ; Pediatrics ; Purpura ; Receptors, Scavenger - biosynthesis</subject><ispartof>Pediatric research, 2021-02, Vol.89 (3), p.667-672</ispartof><rights>International Pediatric Research Foundation, Inc 2020</rights><rights>International Pediatric Research Foundation, Inc 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-559e249dcf95b6a578e91b2ba8d99811e32612952e2567ef608a9ed490e65d053</citedby><cites>FETCH-LOGICAL-c372t-559e249dcf95b6a578e91b2ba8d99811e32612952e2567ef608a9ed490e65d053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41390-020-0951-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41390-020-0951-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32408340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Irabu, Hitoshi</creatorcontrib><creatorcontrib>Shimizu, Masaki</creatorcontrib><creatorcontrib>Kaneko, Shuya</creatorcontrib><creatorcontrib>Inoue, Natsumi</creatorcontrib><creatorcontrib>Mizuta, Mao</creatorcontrib><creatorcontrib>Tasaki, Yuko</creatorcontrib><creatorcontrib>Ohta, Kazuhide</creatorcontrib><creatorcontrib>Yachie, Akihiro</creatorcontrib><creatorcontrib>Wada, Taizo</creatorcontrib><title>Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch–Schönlein purpura nephritis</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
To evaluate the apoptosis inhibitor of macrophage (AIM) deposition patterns on the kidneys of children with IgA nephropathy (IgAN) and Henoch–Schönlein purpura nephritis (HSPN) and to investigate the clinical usefulness of serum and/or urinary AIM levels as biomarkers for the disease activity.
Methods
Immunohistochemical study was performed in the kidneys of 37 patients with IgAN and 10 patients with HSPN. Serum and urinary AIM levels in the patients and 20 healthy controls (HCs) were quantified by enzyme-linked immunosorbent assay. The results were compared with clinical features.
Results
In patients with IgAN and HSPN, AIM expression was observed in various areas, including the glomerular mesangial and capillary areas, the proximal and distal tubular epithelial cells, and on infiltrating macrophages in the glomeruli and interstitial areas. Serum and urinary AIM levels were significantly elevated in these patients compared with the HCs. Urinary AIM levels were positively correlated with the histological severity and degree of proteinuria and hematuria as well as urinary β2 microglobulin and urinary
N
-acetyl-β-D-glucosaminidase levels.
Conclusions
AIM plays an important role in the pathogenesis of IgAN and HSPN. Urinary AIM levels can potentially reflect active renal inflammation in these diseases and may represent a useful biomarker for disease activity.
Impact
Urinary AIM levels may represent a useful biomarker for disease activity of IgAN and HSPN.
AIM expression was observed in the glomeruli, tubular epithelial cells, and infiltrating macrophages in glomeruli and interstitial area.
U-AIM/Cr were significantly correlated not only with proteinuria, hematuria, and u-β2MG and u-NAG levels but also with the activity index of histological findings in kidney biopsy specimens.
Our results can emphasize the important role of AIM in the pathogenesis of IgAN and HSPN.</description><subject>Adolescent</subject><subject>Apoptosis</subject><subject>Apoptosis Regulatory Proteins - biosynthesis</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Biopsy</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical Research Article</subject><subject>Disease</subject><subject>Female</subject><subject>Glomerulonephritis, IGA - genetics</subject><subject>Glomerulonephritis, IGA - metabolism</subject><subject>Hematuria</subject><subject>Humans</subject><subject>IgA Vasculitis - genetics</subject><subject>IgA Vasculitis - metabolism</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Japan</subject><subject>Kidney - pathology</subject><subject>Kidney Glomerulus - metabolism</subject><subject>Kidneys</subject><subject>Leukocyte Count</subject><subject>Macrophages - metabolism</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pathogenesis</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Purpura</subject><subject>Receptors, Scavenger - biosynthesis</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1u1TAUhS0Eoo_CApggS0w6SfFvEg-fKkqLKjEAxpaT3Ly45NnBTorejD0wYiNsgJ2wEm6VFiQkJFuW7e8c-95DyHPOTjmT9ausuDSsYAKn0bzgD8iGa4k7paqHZMOY5IU0pj4iT3K-ZowrXavH5EgKxWqp2IZ8305xmmP2mfow-MbPMdHY071rU5wGtwPqMnW08XHv0idItEeg8xlcxqt29jd-PqCWvnWTC4CH7eDHLkGgX_w80MvdlgaYBnRz83CgLnT0AkJsh19fv71vh58_wggon5aEw62sn31-Sh71bszw7G49Jh_PX384uyiu3r25PNteFa2sxFxobUAo07W90U3pdFWD4Y1oXN1h4ZyDFCUXRgsQuqygL1ntDHTKMCh1x7Q8Jier75Ti5wXybPc-tzCOWE1cssVWKSaNEgLRl_-g13FJAX9nhWaSqUoohRRfKexgzgl6OyWPzTtYzuxtbnbNzWJu9jY3y1Hz4s55afbQ_VHcB4WAWIGMV2EH6e_T_3f9DZFEphk</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Irabu, Hitoshi</creator><creator>Shimizu, Masaki</creator><creator>Kaneko, Shuya</creator><creator>Inoue, Natsumi</creator><creator>Mizuta, Mao</creator><creator>Tasaki, Yuko</creator><creator>Ohta, Kazuhide</creator><creator>Yachie, Akihiro</creator><creator>Wada, Taizo</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20210201</creationdate><title>Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch–Schönlein purpura nephritis</title><author>Irabu, Hitoshi ; Shimizu, Masaki ; Kaneko, Shuya ; Inoue, Natsumi ; Mizuta, Mao ; Tasaki, Yuko ; Ohta, Kazuhide ; Yachie, Akihiro ; Wada, Taizo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-559e249dcf95b6a578e91b2ba8d99811e32612952e2567ef608a9ed490e65d053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Apoptosis</topic><topic>Apoptosis Regulatory Proteins - biosynthesis</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Biopsy</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical Research Article</topic><topic>Disease</topic><topic>Female</topic><topic>Glomerulonephritis, IGA - genetics</topic><topic>Glomerulonephritis, IGA - metabolism</topic><topic>Hematuria</topic><topic>Humans</topic><topic>IgA Vasculitis - genetics</topic><topic>IgA Vasculitis - metabolism</topic><topic>Immunohistochemistry</topic><topic>Inflammation</topic><topic>Japan</topic><topic>Kidney - pathology</topic><topic>Kidney Glomerulus - metabolism</topic><topic>Kidneys</topic><topic>Leukocyte Count</topic><topic>Macrophages - metabolism</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Pathogenesis</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Purpura</topic><topic>Receptors, Scavenger - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Irabu, Hitoshi</creatorcontrib><creatorcontrib>Shimizu, Masaki</creatorcontrib><creatorcontrib>Kaneko, Shuya</creatorcontrib><creatorcontrib>Inoue, Natsumi</creatorcontrib><creatorcontrib>Mizuta, Mao</creatorcontrib><creatorcontrib>Tasaki, Yuko</creatorcontrib><creatorcontrib>Ohta, Kazuhide</creatorcontrib><creatorcontrib>Yachie, Akihiro</creatorcontrib><creatorcontrib>Wada, Taizo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Irabu, Hitoshi</au><au>Shimizu, Masaki</au><au>Kaneko, Shuya</au><au>Inoue, Natsumi</au><au>Mizuta, Mao</au><au>Tasaki, Yuko</au><au>Ohta, Kazuhide</au><au>Yachie, Akihiro</au><au>Wada, Taizo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch–Schönlein purpura nephritis</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>89</volume><issue>3</issue><spage>667</spage><epage>672</epage><pages>667-672</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
To evaluate the apoptosis inhibitor of macrophage (AIM) deposition patterns on the kidneys of children with IgA nephropathy (IgAN) and Henoch–Schönlein purpura nephritis (HSPN) and to investigate the clinical usefulness of serum and/or urinary AIM levels as biomarkers for the disease activity.
Methods
Immunohistochemical study was performed in the kidneys of 37 patients with IgAN and 10 patients with HSPN. Serum and urinary AIM levels in the patients and 20 healthy controls (HCs) were quantified by enzyme-linked immunosorbent assay. The results were compared with clinical features.
Results
In patients with IgAN and HSPN, AIM expression was observed in various areas, including the glomerular mesangial and capillary areas, the proximal and distal tubular epithelial cells, and on infiltrating macrophages in the glomeruli and interstitial areas. Serum and urinary AIM levels were significantly elevated in these patients compared with the HCs. Urinary AIM levels were positively correlated with the histological severity and degree of proteinuria and hematuria as well as urinary β2 microglobulin and urinary
N
-acetyl-β-D-glucosaminidase levels.
Conclusions
AIM plays an important role in the pathogenesis of IgAN and HSPN. Urinary AIM levels can potentially reflect active renal inflammation in these diseases and may represent a useful biomarker for disease activity.
Impact
Urinary AIM levels may represent a useful biomarker for disease activity of IgAN and HSPN.
AIM expression was observed in the glomeruli, tubular epithelial cells, and infiltrating macrophages in glomeruli and interstitial area.
U-AIM/Cr were significantly correlated not only with proteinuria, hematuria, and u-β2MG and u-NAG levels but also with the activity index of histological findings in kidney biopsy specimens.
Our results can emphasize the important role of AIM in the pathogenesis of IgAN and HSPN.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>32408340</pmid><doi>10.1038/s41390-020-0951-1</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3998 |
| ispartof | Pediatric research, 2021-02, Vol.89 (3), p.667-672 |
| issn | 0031-3998 1530-0447 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Apoptosis Apoptosis Regulatory Proteins - biosynthesis Biomarkers Biomarkers - metabolism Biopsy Case-Control Studies Child Child, Preschool Clinical Research Article Disease Female Glomerulonephritis, IGA - genetics Glomerulonephritis, IGA - metabolism Hematuria Humans IgA Vasculitis - genetics IgA Vasculitis - metabolism Immunohistochemistry Inflammation Japan Kidney - pathology Kidney Glomerulus - metabolism Kidneys Leukocyte Count Macrophages - metabolism Male Medicine Medicine & Public Health Pathogenesis Pediatric Surgery Pediatrics Purpura Receptors, Scavenger - biosynthesis |
| title | Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch–Schönlein purpura nephritis |
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