Estimating the Effect of Single-Point Mutations on Protein Thermodynamic Stability and Analyzing the Mutation Landscape of the p53 Protein

Nonsynonymous single-nucleotide polymorphisms often result in altered protein stability while playing crucial roles both in the evolution process and in the development of human diseases. Prediction of change in the thermodynamic stability due to such missense mutations will help in protein engineer...

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Veröffentlicht in:	Journal of chemical information and modeling 2020-06, Vol.60 (6), p.3315-3323
Hauptverfasser:	Banerjee, Anupam, Mitra, Pralay
Format:	Artikel
Sprache:	eng
Schlagworte:	Correlation coefficients Humans Machine learning Mutation Nucleotides Point Mutation Protein Stability Proteins Stability analysis Structural integrity Thermodynamics Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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