SOX4 activates CXCL12 in hepatocellular carcinoma cells to modulate endothelial cell migration and angiogenesis in vivo

The overexpression of SOX4 in various kinds of cancer cells was associated with poor prognosis for patients. The role of SOX4 in angiogenesis and tumor microenvironment modulation was recently documented in breast cancer but remains unclear in hepatocellular carcinoma (HCC). In our study, the clinic...

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Veröffentlicht in:	Oncogene 2020-06, Vol.39 (24), p.4695-4710
Hauptverfasser:	Tsai, Chi-Neu, Yu, Shu-Chuan, Lee, Chao-Wei, Pang, Jong-Hwei Su, Wu, Chun-Hsin, Lin, Sey-En, Chung, Yi-Hsiu, Tsai, Chia-Lung, Hsieh, Sen-Yung, Yu, Ming-Chin
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/109 13/89 38/89 59/78 631/67/1504/1610 631/67/327 64/60 96/1 Angiogenesis Animals Apoptosis Blood clot Breast cancer Cancer Carcinoma, Hepatocellular - blood supply Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell adhesion & migration Cell Biology Cell Line, Tumor Cell migration Cell Movement Chemokine CXCL12 - genetics Chemokine CXCL12 - metabolism Chemotaxis Chromatin CRISPR CRISPR-Cas Systems CXCL12 protein CXCR4 protein Development and progression Ectopic expression Endothelial cells Endothelium Hepatocellular carcinoma Hepatoma Human Genetics Human Umbilical Vein Endothelial Cells - metabolism Human Umbilical Vein Endothelial Cells - pathology Humans Immunoprecipitation Internal Medicine Liver cancer Liver Neoplasms, Experimental - blood supply Liver Neoplasms, Experimental - genetics Liver Neoplasms, Experimental - metabolism Liver Neoplasms, Experimental - pathology Male Medical prognosis Medicine Medicine & Public Health Metastases Metastasis Mice Mice, Inbred BALB C Mice, Nude Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neovascularization Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Oncology Oncology, Experimental Patients Prognosis SOXC Transcription Factors - genetics SOXC Transcription Factors - metabolism Thrombosis Thrombosis - genetics Thrombosis - metabolism Thrombosis - pathology Tumor microenvironment Tumor Microenvironment - genetics Tumors Umbilical vein Vascularization Xenografts
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Zusammenfassung:	The overexpression of SOX4 in various kinds of cancer cells was associated with poor prognosis for patients. The role of SOX4 in angiogenesis and tumor microenvironment modulation was recently documented in breast cancer but remains unclear in hepatocellular carcinoma (HCC). In our study, the clinical relevance of SOX4 overexpression in HCC and its role in the tumor microenvironment were investigated. The overexpression of SOX4 (SOX4 high ) in tumor lesions was associated with higher microvessel density ( P = 0.012), tumor thrombosis formation ( P = 0.012), distant metastasis ( P
ISSN:	0950-9232 1476-5594
DOI:	10.1038/s41388-020-1319-z