Clues For Genetic Anticipation In Multiple Endocrine Neoplasia Type 1

Abstract Context Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant hereditary disease caused by the loss of function of the MEN1 gene, a tumor-suppressor gene that encodes the protein menin. It is characterized by the occurrence of primary hyperparathyroidism (pHPT), duodenopan...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2020-07, Vol.105 (7), p.e2491-e2500
Hauptverfasser:	van den Broek, Medard F M, van Nesselrooij, Bernadette P M, Pieterman, Carolina R C, Verrijn Stuart, Annemarie A, van de Ven, Annenienke C, de Herder, Wouter W, Dekkers, Olaf M, Drent, Madeleine L, Havekes, Bas, Kerstens, Michiel N, Bisschop, Peter H, Valk, Gerlof D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Aged, 80 and over Anticipation, Genetic Female Humans Male Middle Aged Multiple Endocrine Neoplasia Type 1 - genetics Mutation Netherlands Proto-Oncogene Proteins - genetics Young Adult
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