Bone Mass, Bone Microstructure and Biomechanics in Patients with Hand Osteoarthritis
ABSTRACT The impact of primary hand osteoarthritis (HOA) on bone mass, microstructure, and biomechanics in the affected skeletal regions is largely unknown. HOA patients and healthy controls (HCs) underwent high‐resolution peripheral quantitative computed tomography (HR‐pQCT). We measured total, tra...
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| Veröffentlicht in: | Journal of bone and mineral research 2020-09, Vol.35 (9), p.1695-1702 |
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| creator | Simon, David Tascilar, Koray Unbehend, Sara Bayat, Sara Berlin, Andreas Liphardt, Anna‐Maria Meinderink, Timo Rech, Juergen Hueber, Axel J Schett, Georg Kleyer, Arnd |
| description | ABSTRACT
The impact of primary hand osteoarthritis (HOA) on bone mass, microstructure, and biomechanics in the affected skeletal regions is largely unknown. HOA patients and healthy controls (HCs) underwent high‐resolution peripheral quantitative computed tomography (HR‐pQCT). We measured total, trabecular, and cortical volumetric bone mineral densities (vBMDs), microstructural attributes, and performed micro–finite element analysis for bone strength. Failure load and scaled multivariate outcome matrices from distal radius and second metacarpal (MCP2) head measurements were analyzed using multiple linear regression adjusting for age, sex, and functional status and reported as adjusted Z‐score differences for total and direct effects. A total of 105 subjects were included (76 HC: 46 women, 30 men; 29 HOA: 23 women, six men). After adjustment, HOA was associated with significant changes in the multivariate outcome matrix from the MCP2 head (p |
| doi_str_mv | 10.1002/jbmr.4046 |
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The impact of primary hand osteoarthritis (HOA) on bone mass, microstructure, and biomechanics in the affected skeletal regions is largely unknown. HOA patients and healthy controls (HCs) underwent high‐resolution peripheral quantitative computed tomography (HR‐pQCT). We measured total, trabecular, and cortical volumetric bone mineral densities (vBMDs), microstructural attributes, and performed micro–finite element analysis for bone strength. Failure load and scaled multivariate outcome matrices from distal radius and second metacarpal (MCP2) head measurements were analyzed using multiple linear regression adjusting for age, sex, and functional status and reported as adjusted Z‐score differences for total and direct effects. A total of 105 subjects were included (76 HC: 46 women, 30 men; 29 HOA: 23 women, six men). After adjustment, HOA was associated with significant changes in the multivariate outcome matrix from the MCP2 head (p < .001) (explained by an increase in cortical vBMD (Δz = 1.07, p = .02) and reduction in the trabecular vBMD (Δz = −0.07, p = .09). Distal radius analysis did not show an overall effect of HOA; however, there was a gender‐study group interaction (p = .044) explained by reduced trabecular vBMD in males (Δz = −1.23, p = .02). HOA was associated with lower failure load (−514 N; 95%CI, −1018 to −9; p = 0.05) apparent in males after adjustment for functional status. HOA is associated with reduced trabecular and increased cortical vBMD in the MCP2 head and a reduction in radial trabecular vBMD and bone strength in males. Further investigations of gender‐specific changes of bone architecture in HOA are warranted. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.</description><identifier>ISSN: 0884-0431</identifier><identifier>EISSN: 1523-4681</identifier><identifier>DOI: 10.1002/jbmr.4046</identifier><identifier>PMID: 32395822</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>ANALYSIS/QUANTITATION OF BONE ; Arthritis ; BIOMECHANICS ; Bone biomechanics ; Bone mass ; BONE QCT/MICROCT ; Bone strength ; Cancellous bone ; Computed tomography ; Cortical bone ; DISEASES AND DISORDERS OF/RELATED TO BONE ; Finite element method ; Hands ; Males ; Metacarpal ; ORTHOPAEDICS ; OSTEOARTHRITIS ; Radius</subject><ispartof>Journal of bone and mineral research, 2020-09, Vol.35 (9), p.1695-1702</ispartof><rights>2020 The Authors. published by American Society for Bone and Mineral Research</rights><rights>2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3886-cf24a0997ac66d84e592334469d12131b871fd178fa0bfeb8d59a90f0891af8d3</citedby><cites>FETCH-LOGICAL-c3886-cf24a0997ac66d84e592334469d12131b871fd178fa0bfeb8d59a90f0891af8d3</cites><orcidid>0000-0001-8740-9615 ; 0000-0001-8310-7820 ; 0000-0002-2026-7728</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbmr.4046$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbmr.4046$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32395822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Simon, David</creatorcontrib><creatorcontrib>Tascilar, Koray</creatorcontrib><creatorcontrib>Unbehend, Sara</creatorcontrib><creatorcontrib>Bayat, Sara</creatorcontrib><creatorcontrib>Berlin, Andreas</creatorcontrib><creatorcontrib>Liphardt, Anna‐Maria</creatorcontrib><creatorcontrib>Meinderink, Timo</creatorcontrib><creatorcontrib>Rech, Juergen</creatorcontrib><creatorcontrib>Hueber, Axel J</creatorcontrib><creatorcontrib>Schett, Georg</creatorcontrib><creatorcontrib>Kleyer, Arnd</creatorcontrib><title>Bone Mass, Bone Microstructure and Biomechanics in Patients with Hand Osteoarthritis</title><title>Journal of bone and mineral research</title><addtitle>J Bone Miner Res</addtitle><description>ABSTRACT
The impact of primary hand osteoarthritis (HOA) on bone mass, microstructure, and biomechanics in the affected skeletal regions is largely unknown. HOA patients and healthy controls (HCs) underwent high‐resolution peripheral quantitative computed tomography (HR‐pQCT). We measured total, trabecular, and cortical volumetric bone mineral densities (vBMDs), microstructural attributes, and performed micro–finite element analysis for bone strength. Failure load and scaled multivariate outcome matrices from distal radius and second metacarpal (MCP2) head measurements were analyzed using multiple linear regression adjusting for age, sex, and functional status and reported as adjusted Z‐score differences for total and direct effects. A total of 105 subjects were included (76 HC: 46 women, 30 men; 29 HOA: 23 women, six men). After adjustment, HOA was associated with significant changes in the multivariate outcome matrix from the MCP2 head (p < .001) (explained by an increase in cortical vBMD (Δz = 1.07, p = .02) and reduction in the trabecular vBMD (Δz = −0.07, p = .09). Distal radius analysis did not show an overall effect of HOA; however, there was a gender‐study group interaction (p = .044) explained by reduced trabecular vBMD in males (Δz = −1.23, p = .02). HOA was associated with lower failure load (−514 N; 95%CI, −1018 to −9; p = 0.05) apparent in males after adjustment for functional status. HOA is associated with reduced trabecular and increased cortical vBMD in the MCP2 head and a reduction in radial trabecular vBMD and bone strength in males. Further investigations of gender‐specific changes of bone architecture in HOA are warranted. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.</description><subject>ANALYSIS/QUANTITATION OF BONE</subject><subject>Arthritis</subject><subject>BIOMECHANICS</subject><subject>Bone biomechanics</subject><subject>Bone mass</subject><subject>BONE QCT/MICROCT</subject><subject>Bone strength</subject><subject>Cancellous bone</subject><subject>Computed tomography</subject><subject>Cortical bone</subject><subject>DISEASES AND DISORDERS OF/RELATED TO BONE</subject><subject>Finite element method</subject><subject>Hands</subject><subject>Males</subject><subject>Metacarpal</subject><subject>ORTHOPAEDICS</subject><subject>OSTEOARTHRITIS</subject><subject>Radius</subject><issn>0884-0431</issn><issn>1523-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp10E9LwzAYx_EgipvTg29ACl4U7PbkT7Pk6IY6ZWMi81zSNmUZa6tJyti7t7XTg-ApOXz48fBF6BLDEAOQ0SYp7JAB40eojyNCQ8YFPkZ9EIKFwCjuoTPnNgDAI85PUY8SKiNBSB-tJlWpg4Vy7i7ovia1lfO2Tn1tdaDKLJiYqtDpWpUmdYEpg1fljS69C3bGr4NZS5bO60pZv7bGG3eOTnK1dfri8A7Q--PDajoL58un5-n9PEypEDxMc8IUSDlWKeeZYDqShFLGuMwwwRQnYozzDI9FriDJdSKySCoJOQiJVS4yOkA33e6HrT5r7XxcGJfq7VaVuqpdTBhggRlw3NDrP3RT1bZsrmsUw42UIBp126m2gbM6jz-sKZTdxxjiNnXcpo7b1I29OizWSaGzX_nTtgGjDuzMVu__X4pfJou378kvt2aHSw</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Simon, David</creator><creator>Tascilar, Koray</creator><creator>Unbehend, Sara</creator><creator>Bayat, Sara</creator><creator>Berlin, Andreas</creator><creator>Liphardt, Anna‐Maria</creator><creator>Meinderink, Timo</creator><creator>Rech, Juergen</creator><creator>Hueber, Axel J</creator><creator>Schett, Georg</creator><creator>Kleyer, Arnd</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TS</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8740-9615</orcidid><orcidid>https://orcid.org/0000-0001-8310-7820</orcidid><orcidid>https://orcid.org/0000-0002-2026-7728</orcidid></search><sort><creationdate>202009</creationdate><title>Bone Mass, Bone Microstructure and Biomechanics in Patients with Hand Osteoarthritis</title><author>Simon, David ; Tascilar, Koray ; Unbehend, Sara ; Bayat, Sara ; Berlin, Andreas ; Liphardt, Anna‐Maria ; Meinderink, Timo ; Rech, Juergen ; Hueber, Axel J ; Schett, Georg ; Kleyer, Arnd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3886-cf24a0997ac66d84e592334469d12131b871fd178fa0bfeb8d59a90f0891af8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>ANALYSIS/QUANTITATION OF BONE</topic><topic>Arthritis</topic><topic>BIOMECHANICS</topic><topic>Bone biomechanics</topic><topic>Bone mass</topic><topic>BONE QCT/MICROCT</topic><topic>Bone strength</topic><topic>Cancellous bone</topic><topic>Computed tomography</topic><topic>Cortical bone</topic><topic>DISEASES AND DISORDERS OF/RELATED TO BONE</topic><topic>Finite element method</topic><topic>Hands</topic><topic>Males</topic><topic>Metacarpal</topic><topic>ORTHOPAEDICS</topic><topic>OSTEOARTHRITIS</topic><topic>Radius</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Simon, David</creatorcontrib><creatorcontrib>Tascilar, Koray</creatorcontrib><creatorcontrib>Unbehend, Sara</creatorcontrib><creatorcontrib>Bayat, Sara</creatorcontrib><creatorcontrib>Berlin, Andreas</creatorcontrib><creatorcontrib>Liphardt, Anna‐Maria</creatorcontrib><creatorcontrib>Meinderink, Timo</creatorcontrib><creatorcontrib>Rech, Juergen</creatorcontrib><creatorcontrib>Hueber, Axel J</creatorcontrib><creatorcontrib>Schett, Georg</creatorcontrib><creatorcontrib>Kleyer, Arnd</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bone and mineral research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simon, David</au><au>Tascilar, Koray</au><au>Unbehend, Sara</au><au>Bayat, Sara</au><au>Berlin, Andreas</au><au>Liphardt, Anna‐Maria</au><au>Meinderink, Timo</au><au>Rech, Juergen</au><au>Hueber, Axel J</au><au>Schett, Georg</au><au>Kleyer, Arnd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone Mass, Bone Microstructure and Biomechanics in Patients with Hand Osteoarthritis</atitle><jtitle>Journal of bone and mineral research</jtitle><addtitle>J Bone Miner Res</addtitle><date>2020-09</date><risdate>2020</risdate><volume>35</volume><issue>9</issue><spage>1695</spage><epage>1702</epage><pages>1695-1702</pages><issn>0884-0431</issn><eissn>1523-4681</eissn><abstract>ABSTRACT
The impact of primary hand osteoarthritis (HOA) on bone mass, microstructure, and biomechanics in the affected skeletal regions is largely unknown. HOA patients and healthy controls (HCs) underwent high‐resolution peripheral quantitative computed tomography (HR‐pQCT). We measured total, trabecular, and cortical volumetric bone mineral densities (vBMDs), microstructural attributes, and performed micro–finite element analysis for bone strength. Failure load and scaled multivariate outcome matrices from distal radius and second metacarpal (MCP2) head measurements were analyzed using multiple linear regression adjusting for age, sex, and functional status and reported as adjusted Z‐score differences for total and direct effects. A total of 105 subjects were included (76 HC: 46 women, 30 men; 29 HOA: 23 women, six men). After adjustment, HOA was associated with significant changes in the multivariate outcome matrix from the MCP2 head (p < .001) (explained by an increase in cortical vBMD (Δz = 1.07, p = .02) and reduction in the trabecular vBMD (Δz = −0.07, p = .09). Distal radius analysis did not show an overall effect of HOA; however, there was a gender‐study group interaction (p = .044) explained by reduced trabecular vBMD in males (Δz = −1.23, p = .02). HOA was associated with lower failure load (−514 N; 95%CI, −1018 to −9; p = 0.05) apparent in males after adjustment for functional status. HOA is associated with reduced trabecular and increased cortical vBMD in the MCP2 head and a reduction in radial trabecular vBMD and bone strength in males. Further investigations of gender‐specific changes of bone architecture in HOA are warranted. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32395822</pmid><doi>10.1002/jbmr.4046</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8740-9615</orcidid><orcidid>https://orcid.org/0000-0001-8310-7820</orcidid><orcidid>https://orcid.org/0000-0002-2026-7728</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Wiley Online Library All Journals |
| subjects | ANALYSIS/QUANTITATION OF BONE Arthritis BIOMECHANICS Bone biomechanics Bone mass BONE QCT/MICROCT Bone strength Cancellous bone Computed tomography Cortical bone DISEASES AND DISORDERS OF/RELATED TO BONE Finite element method Hands Males Metacarpal ORTHOPAEDICS OSTEOARTHRITIS Radius |
| title | Bone Mass, Bone Microstructure and Biomechanics in Patients with Hand Osteoarthritis |
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