Acid-labile anhydride-linked doxorubicin-doxorubicin dimer nanoparticles as drug self-delivery system with minimized premature drug leakage and enhanced anti-tumor efficacy

[Display omitted] •Acid-labile doxorubicin dimers were designed as prodrug with different anhydrides.•DSDS nanoparticles were self-assembled with Dh of 162 nm and drug content of 51.20%.•They showed excellent pH-triggered tumor-specific release with very low drug leakage.•Enhanced anti-tumor efficac...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2020-08, Vol.192, p.111064-111064, Article 111064
Hauptverfasser:	Li, Jiagen, Li, Xinming, Pei, Mingliang, Liu, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Doxorubicin dimer Drug self-delivery system Enhanced anti-tumor efficacy Prodrug nanoparticles
Online-Zugang:	Volltext
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