T-Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of Coronavirus Disease 2019
Abstract This study evaluated the significance of lymphocyte subset detection in peripheral blood in the diagnosis and prognosis of coronavirus disease 2019 (COVID-19). Our results revealed that CD3+ T cells, CD4+ T cells, CD8+ T cells, and natural killer cells were significantly decreased in patien...
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| Veröffentlicht in: | The Journal of infectious diseases 2020-06, Vol.222 (2), p.198-202 |
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| container_title | The Journal of infectious diseases |
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| creator | Jiang, Mei Guo, Yang Luo, Qing Huang, ZiKun Zhao, Rui Liu, ShuYuan Le, AiPing Li, JunMing Wan, LaGen |
| description | Abstract
This study evaluated the significance of lymphocyte subset detection in peripheral blood in the diagnosis and prognosis of coronavirus disease 2019 (COVID-19). Our results revealed that CD3+ T cells, CD4+ T cells, CD8+ T cells, and natural killer cells were significantly decreased in patients with COVID-19. These patients had a relatively slight decrease in CD4+ T cells but a severe decrease in CD8+ T cells. The significantly elevated CD4/CD8 ratio was observed in COVID-19 patients. T-cell subset counts were related to the severity and prognosis of COVID-19, suggesting that the counts of CD8+ T and CD4+ T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity.
Our results demonstrated that significantly decreased T-cell subset counts were related to the severity and prognosis of COVID-19. Consequently, the counts of CD8+ and CD4+ T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity. |
| doi_str_mv | 10.1093/infdis/jiaa252 |
| format | Article |
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This study evaluated the significance of lymphocyte subset detection in peripheral blood in the diagnosis and prognosis of coronavirus disease 2019 (COVID-19). Our results revealed that CD3+ T cells, CD4+ T cells, CD8+ T cells, and natural killer cells were significantly decreased in patients with COVID-19. These patients had a relatively slight decrease in CD4+ T cells but a severe decrease in CD8+ T cells. The significantly elevated CD4/CD8 ratio was observed in COVID-19 patients. T-cell subset counts were related to the severity and prognosis of COVID-19, suggesting that the counts of CD8+ T and CD4+ T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity.
Our results demonstrated that significantly decreased T-cell subset counts were related to the severity and prognosis of COVID-19. Consequently, the counts of CD8+ and CD4+ T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiaa252</identifier><identifier>PMID: 32379887</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Betacoronavirus ; Biomarkers ; Biomarkers - blood ; CD3 antigen ; CD4 antigen ; CD4 Lymphocyte Count ; CD4-CD8 Ratio ; CD8 antigen ; CD8-Positive T-Lymphocytes ; Clinical Laboratory Techniques ; Coronavirus Infections - diagnosis ; Coronavirus Infections - immunology ; Coronaviruses ; COVID-19 ; COVID-19 Testing ; Diagnosis ; Female ; Humans ; Killer Cells, Natural ; Lymphocyte Count ; Lymphocytes ; Lymphocytes T ; Male ; Medical diagnosis ; Medical prognosis ; Middle Aged ; Natural killer cells ; Pandemics ; Patient Acuity ; Peripheral blood ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - immunology ; Prognosis ; SARS-CoV-2 ; Sensitivity and Specificity ; T-Lymphocyte Subsets ; Young Adult</subject><ispartof>The Journal of infectious diseases, 2020-06, Vol.222 (2), p.198-202</ispartof><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-84e45e996c20d06dec129088d17cf624e58813d1af37ee0e6908427b632c982f3</citedby><cites>FETCH-LOGICAL-c397t-84e45e996c20d06dec129088d17cf624e58813d1af37ee0e6908427b632c982f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32379887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Mei</creatorcontrib><creatorcontrib>Guo, Yang</creatorcontrib><creatorcontrib>Luo, Qing</creatorcontrib><creatorcontrib>Huang, ZiKun</creatorcontrib><creatorcontrib>Zhao, Rui</creatorcontrib><creatorcontrib>Liu, ShuYuan</creatorcontrib><creatorcontrib>Le, AiPing</creatorcontrib><creatorcontrib>Li, JunMing</creatorcontrib><creatorcontrib>Wan, LaGen</creatorcontrib><title>T-Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of Coronavirus Disease 2019</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Abstract
This study evaluated the significance of lymphocyte subset detection in peripheral blood in the diagnosis and prognosis of coronavirus disease 2019 (COVID-19). Our results revealed that CD3+ T cells, CD4+ T cells, CD8+ T cells, and natural killer cells were significantly decreased in patients with COVID-19. These patients had a relatively slight decrease in CD4+ T cells but a severe decrease in CD8+ T cells. The significantly elevated CD4/CD8 ratio was observed in COVID-19 patients. T-cell subset counts were related to the severity and prognosis of COVID-19, suggesting that the counts of CD8+ T and CD4+ T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity.
Our results demonstrated that significantly decreased T-cell subset counts were related to the severity and prognosis of COVID-19. Consequently, the counts of CD8+ and CD4+ T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Betacoronavirus</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>CD3 antigen</subject><subject>CD4 antigen</subject><subject>CD4 Lymphocyte Count</subject><subject>CD4-CD8 Ratio</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes</subject><subject>Clinical Laboratory Techniques</subject><subject>Coronavirus Infections - diagnosis</subject><subject>Coronavirus Infections - immunology</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 Testing</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Killer Cells, Natural</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Natural killer cells</subject><subject>Pandemics</subject><subject>Patient Acuity</subject><subject>Peripheral blood</subject><subject>Pneumonia, Viral - diagnosis</subject><subject>Pneumonia, Viral - immunology</subject><subject>Prognosis</subject><subject>SARS-CoV-2</subject><subject>Sensitivity and Specificity</subject><subject>T-Lymphocyte Subsets</subject><subject>Young Adult</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT1vFDEQhi0EIkegpUSWaKDYxF_rj5JbPqVIREpSr3zrWfCxZx-e3Uj3O_jDGO6goKFyMc8845mXkOecXXDm5GVMY4h4uY3ei1Y8ICveStNozeVDsmJMiIZb587IE8QtY0xJbR6TMymkcdaaFflx23QwTfRm2SDMtMtLmpHGRK-hxP1XKH6i6ynnQDuf6BroHUKgHunbiEOJu5j8nMuBrmPe-fINCtIxl1r1X1LGiNSnQG_gvtrmA70uEOIwx5xoHuuwkpO_j2X5rQOPQAXj7il5NPoJ4dnpPSd379_ddh-bq88fPnVvrppBOjM3VoFqwTk9CBaYDjBw4Zi1gZth1EJBay2XgftRGgAGuhaVMBstxeCsGOU5eXX07kv-vgDO_a4uVa_hE-QFe6EYa5XT1lT05T_oNi8l1d9VSjkurLKqUhdHaigZscDY7-uJfDn0nPW_4uqPcfWnuGrDi5N22ewg_MX_5FOB10cgL_v_yX4CFvugpA</recordid><startdate>20200629</startdate><enddate>20200629</enddate><creator>Jiang, Mei</creator><creator>Guo, Yang</creator><creator>Luo, Qing</creator><creator>Huang, ZiKun</creator><creator>Zhao, Rui</creator><creator>Liu, ShuYuan</creator><creator>Le, AiPing</creator><creator>Li, JunMing</creator><creator>Wan, LaGen</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20200629</creationdate><title>T-Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of Coronavirus Disease 2019</title><author>Jiang, Mei ; Guo, Yang ; Luo, Qing ; Huang, ZiKun ; Zhao, Rui ; Liu, ShuYuan ; Le, AiPing ; Li, JunMing ; Wan, LaGen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-84e45e996c20d06dec129088d17cf624e58813d1af37ee0e6908427b632c982f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Betacoronavirus</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>CD3 antigen</topic><topic>CD4 antigen</topic><topic>CD4 Lymphocyte Count</topic><topic>CD4-CD8 Ratio</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes</topic><topic>Clinical Laboratory Techniques</topic><topic>Coronavirus Infections - diagnosis</topic><topic>Coronavirus Infections - immunology</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 Testing</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Killer Cells, Natural</topic><topic>Lymphocyte Count</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Natural killer cells</topic><topic>Pandemics</topic><topic>Patient Acuity</topic><topic>Peripheral blood</topic><topic>Pneumonia, Viral - diagnosis</topic><topic>Pneumonia, Viral - immunology</topic><topic>Prognosis</topic><topic>SARS-CoV-2</topic><topic>Sensitivity and Specificity</topic><topic>T-Lymphocyte Subsets</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Mei</creatorcontrib><creatorcontrib>Guo, Yang</creatorcontrib><creatorcontrib>Luo, Qing</creatorcontrib><creatorcontrib>Huang, ZiKun</creatorcontrib><creatorcontrib>Zhao, Rui</creatorcontrib><creatorcontrib>Liu, ShuYuan</creatorcontrib><creatorcontrib>Le, AiPing</creatorcontrib><creatorcontrib>Li, JunMing</creatorcontrib><creatorcontrib>Wan, LaGen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Mei</au><au>Guo, Yang</au><au>Luo, Qing</au><au>Huang, ZiKun</au><au>Zhao, Rui</au><au>Liu, ShuYuan</au><au>Le, AiPing</au><au>Li, JunMing</au><au>Wan, LaGen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T-Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of Coronavirus Disease 2019</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2020-06-29</date><risdate>2020</risdate><volume>222</volume><issue>2</issue><spage>198</spage><epage>202</epage><pages>198-202</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Abstract
This study evaluated the significance of lymphocyte subset detection in peripheral blood in the diagnosis and prognosis of coronavirus disease 2019 (COVID-19). Our results revealed that CD3+ T cells, CD4+ T cells, CD8+ T cells, and natural killer cells were significantly decreased in patients with COVID-19. These patients had a relatively slight decrease in CD4+ T cells but a severe decrease in CD8+ T cells. The significantly elevated CD4/CD8 ratio was observed in COVID-19 patients. T-cell subset counts were related to the severity and prognosis of COVID-19, suggesting that the counts of CD8+ T and CD4+ T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity.
Our results demonstrated that significantly decreased T-cell subset counts were related to the severity and prognosis of COVID-19. Consequently, the counts of CD8+ and CD4+ T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32379887</pmid><doi>10.1093/infdis/jiaa252</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Betacoronavirus Biomarkers Biomarkers - blood CD3 antigen CD4 antigen CD4 Lymphocyte Count CD4-CD8 Ratio CD8 antigen CD8-Positive T-Lymphocytes Clinical Laboratory Techniques Coronavirus Infections - diagnosis Coronavirus Infections - immunology Coronaviruses COVID-19 COVID-19 Testing Diagnosis Female Humans Killer Cells, Natural Lymphocyte Count Lymphocytes Lymphocytes T Male Medical diagnosis Medical prognosis Middle Aged Natural killer cells Pandemics Patient Acuity Peripheral blood Pneumonia, Viral - diagnosis Pneumonia, Viral - immunology Prognosis SARS-CoV-2 Sensitivity and Specificity T-Lymphocyte Subsets Young Adult |
| title | T-Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of Coronavirus Disease 2019 |
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