Xanthophyll β‐Cryptoxanthin Inhibits Highly Refined Carbohydrate Diet–Promoted Hepatocellular Carcinoma Progression in Mice

Scope β‐Cryptoxanthin (BCX) can be cleaved by both β‐carotene 15,15′‐oxygenase (BCO1) and β‐carotene 9′,10′‐oxygenase (BCO2), generating biological active vitamin A and apocarotenoids. We examined whether BCX feeding could inhibit diethylnitrosamine (DEN)‐initiated, highly refined carbohydrate diet...

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Veröffentlicht in:	Molecular nutrition & food research 2020-02, Vol.64 (3), p.e1900949-n/a
Hauptverfasser:	Lim, Ji Ye, Liu, Chun, Hu, Kang‐Quan, Smith, Donald E., Wu, Dayong, Lamon‐Fava, Stefania, Ausman, Lynne M., Wang, Xiang‐Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Apoptosis - drug effects beta-carotene beta-Carotene 15,15'-Monooxygenase - genetics beta-cryptoxanthin Beta-Cryptoxanthin - pharmacology Body weight Body Weight - drug effects Carbohydrates Carcinogenesis Carcinogens Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - pathology Carotene carotenoid cleavage enzymes chemoprevention Diet Dietary Carbohydrates - adverse effects Dietary Supplements Diethylnitrosamine Dioxygenases - genetics Diterpenes - analysis energy Feeding glucose Glucose - metabolism Glycolysis - drug effects Hepatocellular carcinoma hepatoma highly refined carbohydrate diets Hypoxia hypoxia-inducible factor 1 Hypoxia-Inducible Factor 1, alpha Subunit - metabolism intraperitoneal injection L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - etiology Liver Neoplasms - pathology lutein Male males metabolism mice Mice, Inbred C57BL Mice, Knockout Oxygenase p53 Protein protein content Proteins Retinene Retinyl Esters - analysis Steatosis Tumor Hypoxia - drug effects Tumor Microenvironment - drug effects Tumor Suppressor Protein p53 - metabolism Tumors Vitamin A Vitamin A - analysis Xanthophylls β-Carotene β‐Cryptoxanthin
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