Metabolomic profile perturbations of serum, lung, bronchoalveolar lavage fluid, spleen and feces in LPS-induced acute lung injury rats based on HPLC-ESI-QTOF-MS

Acute lung injury (ALI) is a clinically common and serious disease, underscoring the urgent need for clarification of its pathogenesis. According to traditional Chinese medicine (TCM) theories on the “lung–spleen–intestine axis” and its correlation with ALI, a high-performance liquid chromatography–...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2020-02, Vol.412 (5), p.1215-1234
Hauptverfasser:	Wang, Tianyang, Lin, Song, Liu, Ran, Li, Hua, Liu, Zihan, Zhang, Xinnong, Xu, Huarong, Li, Qing, Bi, Kaishun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - blood Acute Lung Injury - metabolism Acute respiratory distress syndrome Alveoli Analysis Analytical Chemistry Animals bile acids biochemical pathways Biochemistry Biomarkers Biomarkers - blood blood serum Bronchoalveolar Lavage Fluid Bronchus Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chromatography, High Pressure Liquid - methods Correlation analysis Cytokines - biosynthesis Disease detection Enzymes - metabolism Feces Food Science Glutathione - metabolism Herbal medicine High performance liquid chromatography Intestine Laboratory Medicine Lavage Linoleic acid Lipopolysaccharides Lipopolysaccharides - toxicity Liquid chromatography Lung - metabolism Lungs Male Malondialdehyde - metabolism Mass spectrometry Mass spectroscopy Metabolic pathways Metabolism Metabolites Metabolomics Methods Monitoring/Environmental Analysis Oriental traditional medicine Pathogenesis Quadrupoles Rats Rats, Wistar Research Paper Sensitivity analysis Serum Spectrometry, Mass, Electrospray Ionization - methods sphingolipids Spleen Spleen - metabolism Statistical analysis Statistical methods Traditional Chinese medicine
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