Imiquimod-induced ROS production disrupts the balance of mitochondrial dynamics and increases mitophagy in skin cancer cells

•Imiquimod induces robust ROS production and cause mitochondrial dysfunction.•Imiquimod undermines mitochondrial dynamics and causes mitochondrial fission.•Imiquimod induces mitophagy.•Diminishing imiquimod-induced ROS reduces mitochondrial fission and mitophagy. Mitochondrial homeostasis is a highl...

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Veröffentlicht in:	Journal of dermatological science 2020-06, Vol.98 (3), p.152-162
Hauptverfasser:	Chuang, Kai-Cheng, Chang, Chuang-Rung, Chang, Shu-Hao, Huang, Shi-Wei, Chuang, Show-Mei, Li, Zheng-Yi, Wang, Sin-Ting, Kao, Jun-Kai, Chen, Yi-Ju, Shieh, Jeng-Jer
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antioxidants - pharmacology Cell Line, Tumor Cell Survival - drug effects Free Radical Scavengers - pharmacology Humans Imiquimod Imiquimod - pharmacology Imiquimod - therapeutic use Keratinocytes Mice Mitochondria - drug effects Mitochondria - metabolism Mitochondrial dynamics Mitochondrial Dynamics - drug effects Mitophagy Mitophagy - drug effects Primary Cell Culture Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism ROS (reactive oxygen species) Signal Transduction - drug effects Skin Neoplasms - drug therapy Skin Neoplasms - pathology
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