Toward a Stable and Potent Coenzyme A‑Targeting Antiplasmodial Agent: Structure–Activity Relationship Studies of N‑Phenethyl-α-methyl-pantothenamide

Pantothenamides (PanAms) are potent antiplasmodials with low human toxicity currently being investigated as antimalarials with a novel mode of action. These structural analogues of pantothenate, the vitamin precursor of the essential cofactor coenzyme A, are susceptible to degradation by pantetheina...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ACS infectious diseases 2020-07, Vol.6 (7), p.1844-1854
Hauptverfasser:	Spry, Christina, Barnard, Leanne, Kok, Michélle, Powell, Andrew K, Mahesh, Darvina, Tjhin, Erick T, Saliba, Kevin J, Strauss, Erick, de Villiers, Marianne
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!