Changes in three-dimensional arterial spin labeling perfusion imaging of the hippocampus in depressive Itpr2-/- mice

Changes in three-dimensional arterial spin labeling perfusion imaging of the hippocampus in depressive Itpr2-/- mice

OBJECTIVETo study the behavioral changes of inositol 1, 4, 5-trisphosphate receptor type 2 knockout (Itpr2-/- mice) and investigate the blood perfusion changes in the hippocampus using three-dimensional arterial spin labeling (3D-ASL). METHODS28 Itpr2-/- mice and 20 wild-type mice were assessed for...

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Veröffentlicht in:Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2020-01, Vol.40 (1), p.56-60
Hauptverfasser: Zeng, Shanmei, Liu, Kai, Zhang, Jingyu, Wu, Yulan, Xu, Yihua, Sun, Xuegang, Wen, Ge
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container_title Nan fang yi ke da xue xue bao = Journal of Southern Medical University
container_volume 40
creator Zeng, Shanmei
Liu, Kai
Zhang, Jingyu
Wu, Yulan
Xu, Yihua
Sun, Xuegang
Wen, Ge
description OBJECTIVETo study the behavioral changes of inositol 1, 4, 5-trisphosphate receptor type 2 knockout (Itpr2-/- mice) and investigate the blood perfusion changes in the hippocampus using three-dimensional arterial spin labeling (3D-ASL). METHODS28 Itpr2-/- mice and 20 wild-type mice were assessed for depressive phenotype using behavioral tests (including sucrose consumption test, tail suspension test, forced swimming test and open field test). 15 Itpr2-/- mice and 14 wild-type mice were randomly selected for 3D-T2WI imaging of the whole brain and 3D-ASL imaging of the middle hippocampal layer, and cerebral blood flow (CBF) of the middle hippocampal layer was calculated. ITK-SNAP was used to delineate the bilateral hippocampal area and measure the average CBF value. RESULTSCompared with the wild-type mice, Itpr2-/- mice exhibited a distinct depressive phenotype with significantly decreased sucrose preference (P < 0.05) and increased immobile time in tail suspension test (P < 0.05) and forced swimming test (P < 0
doi_str_mv 10.12122/j.issn.1673-4254.2020.01.09
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title Changes in three-dimensional arterial spin labeling perfusion imaging of the hippocampus in depressive Itpr2-/- mice
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