Cytotoxic Meroterpenoids from the Fungus Alternaria sp. JJY‐32

Cytotoxic Meroterpenoids from the Fungus Alternaria sp. JJY‐32

Two new meroterpenoids, tricycloalternarenes X and Y, together with one known meroterpenoid, tricycloalternarene I, were isolated from the fungus Alternaria sp. JJY‐32. The structures including absolute configurations were established by the comprehensive spectroscopic data, electronic circular dich...

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Veröffentlicht in:Chemistry & biodiversity 2020-07, Vol.17 (7), p.e2000226-n/a
Hauptverfasser: Wang, Lu, Jiao, Jieying, Liu, Dan, Zhang, Xiaomin, Li, Jing, Che, Qian, Zhu, Tianjiao, Zhang, Guojian, Li, Dehai
Format: Artikel
Sprache:eng
Schlagworte:
Alternaria
Alternaria sp
Biosynthesis
Circular dichroism
Cytotoxicity
Dichroism
Fungi
meroterpenoids
Toxicity
tricycloalternarene
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Zusammenfassung:Two new meroterpenoids, tricycloalternarenes X and Y, together with one known meroterpenoid, tricycloalternarene I, were isolated from the fungus Alternaria sp. JJY‐32. The structures including absolute configurations were established by the comprehensive spectroscopic data, electronic circular dichroism (ECD) spectral analyses, and biosynthesis consideration. Tricycloalternarene X showed cytotoxicity against the HL‐60 and HO8910 cells with IC50 values of 7.54 and 20.32 μm.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202000226