Cognitive disturbances in the cuprizone model of multiple sclerosis

Cognitive problems frequently accompany neurological manifestations of multiple sclerosis (MS). However, during screening of preclinical candidates, assessments of behaviour in mouse models of MS typically focus on locomotor activity. In the present study, we analysed cognitive behaviour of 9 to 10‐...

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Veröffentlicht in:	Genes, brain and behavior brain and behavior, 2021-01, Vol.20 (1), p.e12663-n/a
Hauptverfasser:	Kopanitsa, Maksym V., Lehtimäki, Kimmo K., Forsman, Markku, Suhonen, Ari, Koponen, Juho, Piiponniemi, Tuukka O., Kärkkäinen, Anna‐Mari, Pavlidi, Pavlina, Shatillo, Artem, Sweeney, Patrick J., Merenlender‐Wagner, Avia, Kaye, Joel, Orbach, Aric, Nurmi, Antti
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Anisotropy Cognition Cognition & reasoning Cognitive ability Conditioning, Operant Corpus Callosum - diagnostic imaging Cuprizone Cuprizone - toxicity Demyelination diffusion tensor imaging Drug development Fear conditioning Female Interactive computer systems Learning Locomotor activity Magnetic resonance imaging Mice Mice, Inbred C57BL MRI Multiple sclerosis Multiple Sclerosis - etiology Multiple Sclerosis - physiopathology Neuroimaging Operant conditioning Oral administration Substantia alba Tonic immobility touchscreen Visual Perception Visual stimuli
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