Ameliorative effect of 2-methoxyestradiol on radiation-induced lung injury

Radiation-induced lung injury (RILI) is a serious complication of radiation therapy. Development of an effective drug that selectively protects normal lung tissues and sensitizes tumor cells to radiotherapy is an unmet need. 2-Methoxyestradiol (2ME2) possesses polypharmacological properties, which q...

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Veröffentlicht in:	Life sciences (1973) 2020-08, Vol.255, p.117743-117743, Article 117743
Hauptverfasser:	Elzayat, Mohamed Abdel-Mohsen, Bayoumi, Asmaa M.A., Abdel-Bakky, Mohamed Sadek, Mansour, Ahmed M., Kamel, Marwa, Abo-Saif, Ali, Allam, Shady, Salama, Abeer, Salama, Salama A.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Methoxyestradiol Alveoli Arginase Enzyme-linked immunosorbent assay Evaluation Fibrosis Flow cytometry Fluid flow HIF-1α Hypoxia-inducible factor 1a Immunofluorescence Interleukin 10 Ionizing radiation Lungs Macrophages Markers Nitric oxide Nitric-oxide synthase Phenotyping Pneumonitis Pulmonary functions Radiation effects Radiation injuries Radiation therapy Radiation-induced lung injury Respiratory function Side effects Survival TGF-β Tissues TNF-α Tumor cells Tumor necrosis factor-α Vascular endothelial growth factor
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