$Dynamic Crystallization Pathways of Polymorphic Pharmaceuticals Revealed in Segmented Flow with Inline Powder X-ray Diffraction$

Dynamic Crystallization Pathways of Polymorphic Pharmaceuticals Revealed in Segmented Flow with Inline Powder X-ray Diffraction

Understanding the transitions between polymorphs is essential in the development of strategies for manufacturing and maximizing the efficiency of pharmaceuticals. However, this can be extremely challenging: crystallization can be influenced by subtle changes in environment, such as temperature and m...

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Veröffentlicht in:	Analytical chemistry (Washington) 2020-06, Vol.92 (11), p.7754-7761
Hauptverfasser:	Levenstein, Mark A, Wayment, Lois, Scott, C Daniel, Lunt, Ruth, Flandrin, Pierre-Baptiste, Day, Sarah J, Tang, Chiu C, Wilson, Chick C, Meldrum, Fiona C, Kapur, Nikil, Robertson, Karen
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Barbiturates - chemistry Carbamazepine Carbamazepine - chemistry Chemistry Crystallization Crystals Free energy In situ measurement Pharmaceutical Preparations - chemistry Pharmaceuticals Phase relationships Powder Diffraction Reaction kinetics Seeds Urea Urea - chemistry X ray powder diffraction X-ray diffraction
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