IL26, a Noncanonical Mediator of DNA Inflammatory Stimulation, Promotes TNBC Engraftment and Progression in Association with Neutrophils

IL26 is a unique amphipathic member of the IL10 family of cytokines that participates in inflammatory signaling through a canonical receptor pathway. It also directly binds DNA to facilitate cellular transduction and intracellular inflammatory signaling. Although IL26 has almost no described role in...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2020-08, Vol.80 (15), p.3088-3100
Hauptverfasser:	Trotter, Timothy N, Shuptrine, Casey W, Tsao, Li-Chung, Marek, Robert D, Acharya, Chaitanya, Wei, Jun-Ping, Yang, Xiao-Yi, Lei, Gangjun, Wang, Tao, Lyerly, Herbert Kim, Hartman, Zachary C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion - drug effects Cell Adhesion - genetics Cells, Cultured Disease Progression DNA, Neoplasm - drug effects DNA, Neoplasm - metabolism Extracellular Traps - drug effects Extracellular Traps - metabolism Female Gene Expression Regulation, Neoplastic HEK293 Cells Humans Inflammation Mediators - pharmacology Inflammation Mediators - physiology Interleukins - genetics Interleukins - pharmacology Interleukins - physiology Mice Mice, Inbred C57BL Mice, SCID Neoplasm Transplantation - immunology Neoplasm Transplantation - pathology Neutrophils - pathology Neutrophils - physiology Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - pathology Xenograft Model Antitumor Assays
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