Activation of Steroidogenesis, Anti-Apoptotic Activity, and Proliferation in Porcine Granulosa Cells by RUNX1 Is Negatively Regulated by H3K27me3 Transcriptional Repression

H3K27me3 is an epigenetic modification that results in the repression of gene transcription. The transcription factor RUNX1 (the runt-related transcription factor 1) influences granulosa cells' growth and ovulation. This research uses ELISA, flow cytometry, EDU, ChIP-PCR, WB and qPCR to investi...

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Veröffentlicht in:	Genes 2020-04, Vol.11 (5), p.495, Article 495
Hauptverfasser:	Zhong, Yuyi, Li, Liying, He, Yingting, He, Bo, Li, Zhonghui, Zhang, Zhe, Zhang, Hao, Yuan, Xiaolong, Li, Jiaqi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - genetics Cell Proliferation - genetics Core Binding Factor Alpha 2 Subunit - genetics Estrogens - biosynthesis Estrogens - genetics Female Follicle Stimulating Hormone - biosynthesis Follicle Stimulating Hormone - genetics Gene Expression Regulation, Developmental - genetics Genetics & Heredity Granulosa Cells - metabolism Humans Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors Jumonji Domain-Containing Histone Demethylases - genetics Life Sciences & Biomedicine Ovulation - genetics Progesterone - biosynthesis Progesterone - genetics RNA, Messenger - genetics Science & Technology Steroids - biosynthesis Steroids - metabolism
Online-Zugang:	Volltext
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