FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome

The crosstalk between deregulated hepatocyte metabolism and cells within the tumour microenvironment, as well as the consequent effects on liver tumorigenesis, are not completely understood. We show here that hepatocyte-specific loss of the gluconeogenic enzyme fructose 1,6-bisphosphatase 1 (FBP1) d...

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Veröffentlicht in:	Nature cell biology 2020-06, Vol.22 (6), p.728-739
Hauptverfasser:	Li, Fuming, Huangyang, Peiwei, Burrows, Michelle, Guo, Kathy, Riscal, Romain, Godfrey, Jason, Lee, Kyoung Eun, Lin, Nan, Lee, Pearl, Blair, Ian A., Keith, Brian, Li, Bo, Simon, M. Celeste
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 14/28 14/63 38/77 38/91 631/67/1504/1610 631/80/509 64/60 692/699/67/2327 692/699/67/327 82/58 Activation Animals Biomedical and Life Sciences Cancer Research Carcinogenesis - metabolism Carcinogenesis - pathology Cell Biology Cell Proliferation Cellular Senescence Crosstalk Deregulation Development and progression Developmental Biology Enzymes Fatty liver Female Fructose Fructose-Bisphosphatase - physiology Gene Expression Regulation, Neoplastic Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - pathology Hepatocytes HMGB1 protein Homeostasis Humans Life Sciences Liver Liver cancer Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Metabolism Mice Mice, Inbred C57BL Mice, Knockout Phenotypes Physiological aspects Quercetin Secretome Senescence Steatosis Stellate cells Stem Cells Tumor Microenvironment Tumorigenesis Tumors Xenograft Model Antitumor Assays
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