YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation

N 6 -methyladenosine (m6A) RNA methylation contributes to the cancer stem cell (CSC) phenotype through regulating gene expression. YTHDF2, an m6A reader, was shown to be associated with hepatocellular carcinoma (HCC) patient prognosis. However, the effect of YTHDF2 on liver CSC and cancer metastasis...

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Veröffentlicht in:	Oncogene 2020-06, Vol.39 (23), p.4507-4518
Hauptverfasser:	Zhang, Chuanzhao, Huang, Shanzhou, Zhuang, Hongkai, Ruan, Shiye, Zhou, Zixuan, Huang, Kaijun, Ji, Fei, Ma, Zuyi, Hou, Baohua, He, Xiaoshun
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/105 38/1 38/91 42/109 5' Untranslated Regions 631/67/1504/1610 631/67/71 64/60 82/51 Adenosine - analogs & derivatives Adenosine - metabolism Animals Apoptosis Cancer Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Cell Biology Cell culture DNA methylation Gene expression Gene Expression Regulation, Neoplastic - genetics Genes Genetic aspects Genomes Genomics Genotype & phenotype Hep G2 Cells Hepatocellular carcinoma Hepatocytes Human Genetics Humans Internal Medicine Liver - pathology Liver cancer Liver Neoplasms - mortality Liver Neoplasms - pathology Luciferase Male Medical prognosis Medicine Medicine & Public Health Metastases Metastasis Methylation Methyltransferases Mice Mice, Inbred BALB C Mice, Nude N6-methyladenosine Neoplasm Metastasis - pathology Neoplasm Transplantation Neoplastic Stem Cells - pathology Oct-4 protein Octamer Transcription Factor-3 - metabolism Oncology Phenotypes Prognosis RNA RNA, Messenger - metabolism RNA-Binding Proteins - genetics Spheroids, Cellular Stem cells Translation Transplantation, Heterologous Tumor Cells, Cultured
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