External auditory canal carcinoma: clinical characteristics and long-term treatment outcomes
Purpose Evidence-based treatment recommendations for external auditory canal (EAC) carcinoma are lacking in available literature. This study aims to evaluate the clinical characteristics and long-term outcomes of EAC carcinoma in a tertiary referral centre in a period of 15 years and identify indepe...
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| Veröffentlicht in: | European archives of oto-rhino-laryngology 2020-10, Vol.277 (10), p.2709-2720 |
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| creator | Correia-Rodrigues, Pedro Ramalho, Sara Montalvão, Pedro Magalhães, Miguel |
| description | Purpose
Evidence-based treatment recommendations for external auditory canal (EAC) carcinoma are lacking in available literature. This study aims to evaluate the clinical characteristics and long-term outcomes of EAC carcinoma in a tertiary referral centre in a period of 15 years and identify independent prognostic factors.
Methods
Retrospective observational study enrolling all patients with primary EAC carcinoma who underwent primary surgical treatment at the Portuguese Institute of Oncology (Lisbon) between 2004 and 2018. Epidemiological, clinical, histopathological and surgical data were retrieved from clinical records and analysed.
Results
Twenty-seven patients were identified, with a median age of 77 years (range 29–92 years) and a slight female predominance (59.3%). Squamous cell carcinoma (55.6%) was the most common histological type, followed by basal cell carcinoma (40.7%) and ceruminous adenocarcinoma (3.7%). Pittsburgh tumour staging was distributed as early stage in 51.9% (I: 40.7%; II: 11.1%) and advanced stage in 48.1% (III: 29.6%; IV: 18.5%). Median follow-up period was 21 months (interquartile-range: 47). Four patients (14.8%) showed recurrence; recurrence rate was significantly higher in individuals aged |
| doi_str_mv | 10.1007/s00405-020-06019-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2398624077</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2398624077</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-90b1165d967d1d20b3ee20e4112afc2ed952483b58f65e7592c9445863870f493</originalsourceid><addsrcrecordid>eNp9kD1PwzAQhi0EoqXwBxhQRhbD-SuO2VBVPqRKLLAhWa7jlFRJXGxHov-ehBZGptPdPfdK9yB0SeCGAMjbCMBBYKCAIQeiMD1CU8IZx1zS_BhNQTGJOZdygs5i3ACA4IqdogmjLJdE0Cl6X3wlFzrTZKYv6-TDLrNmbK0Jtu58a-4y29RdbcfZhwnGDnwdU21jZroya3y3xsOozVJwJrWuS5nvk_Wti-fopDJNdBeHOkNvD4vX-RNevjw-z--X2DIuE1awIiQXpcplSUoKK-YcBccJoaay1JVKUF6wlSiqXDgpFLWKc1HkrJBQDR_N0PU-dxv8Z-9i0m0drWsa0znfR02ZKnLKQcoBpXvUBh9jcJXehro1YacJ6NGq3lvVg1X9Y3W4nqGrQ36_al35d_KrcQDYHojDqlu7oDe-H63G_2K_AV04gpU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2398624077</pqid></control><display><type>article</type><title>External auditory canal carcinoma: clinical characteristics and long-term treatment outcomes</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Correia-Rodrigues, Pedro ; Ramalho, Sara ; Montalvão, Pedro ; Magalhães, Miguel</creator><creatorcontrib>Correia-Rodrigues, Pedro ; Ramalho, Sara ; Montalvão, Pedro ; Magalhães, Miguel</creatorcontrib><description>Purpose
Evidence-based treatment recommendations for external auditory canal (EAC) carcinoma are lacking in available literature. This study aims to evaluate the clinical characteristics and long-term outcomes of EAC carcinoma in a tertiary referral centre in a period of 15 years and identify independent prognostic factors.
Methods
Retrospective observational study enrolling all patients with primary EAC carcinoma who underwent primary surgical treatment at the Portuguese Institute of Oncology (Lisbon) between 2004 and 2018. Epidemiological, clinical, histopathological and surgical data were retrieved from clinical records and analysed.
Results
Twenty-seven patients were identified, with a median age of 77 years (range 29–92 years) and a slight female predominance (59.3%). Squamous cell carcinoma (55.6%) was the most common histological type, followed by basal cell carcinoma (40.7%) and ceruminous adenocarcinoma (3.7%). Pittsburgh tumour staging was distributed as early stage in 51.9% (I: 40.7%; II: 11.1%) and advanced stage in 48.1% (III: 29.6%; IV: 18.5%). Median follow-up period was 21 months (interquartile-range: 47). Four patients (14.8%) showed recurrence; recurrence rate was significantly higher in individuals aged < 60 years (
p
= 0.025) and with lymphovascular invasion (
p
= 0.049). Median overall survival was 88 months and estimated 2-year and 5-year overall survival rates were both 66%. Survival rates were higher in early stage patients (
p
= 0.021) and in those without facial palsy (
p
= 0.032).
Conclusion
Based on the available evidence in this review, individuals aged < 60, facial nerve impairment, advanced stage lesions, presence of lymphovascular invasion and squamous cell carcinoma histology are all associated with poor outcome and may be considered when discussing optimal treatment strategies in patients with EAC carcinoma.</description><identifier>ISSN: 0937-4477</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/s00405-020-06019-2</identifier><identifier>PMID: 32367152</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Ear Canal - pathology ; Ear Neoplasms - pathology ; Ear Neoplasms - surgery ; Female ; Head and Neck Surgery ; Humans ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Recurrence, Local - epidemiology ; Neoplasm Recurrence, Local - pathology ; Neoplasm Staging ; Neurosurgery ; Observational Studies as Topic ; Otology ; Otorhinolaryngology ; Retrospective Studies ; Treatment Outcome</subject><ispartof>European archives of oto-rhino-laryngology, 2020-10, Vol.277 (10), p.2709-2720</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-90b1165d967d1d20b3ee20e4112afc2ed952483b58f65e7592c9445863870f493</citedby><cites>FETCH-LOGICAL-c347t-90b1165d967d1d20b3ee20e4112afc2ed952483b58f65e7592c9445863870f493</cites><orcidid>0000-0001-5193-1188</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00405-020-06019-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00405-020-06019-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32367152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Correia-Rodrigues, Pedro</creatorcontrib><creatorcontrib>Ramalho, Sara</creatorcontrib><creatorcontrib>Montalvão, Pedro</creatorcontrib><creatorcontrib>Magalhães, Miguel</creatorcontrib><title>External auditory canal carcinoma: clinical characteristics and long-term treatment outcomes</title><title>European archives of oto-rhino-laryngology</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><description>Purpose
Evidence-based treatment recommendations for external auditory canal (EAC) carcinoma are lacking in available literature. This study aims to evaluate the clinical characteristics and long-term outcomes of EAC carcinoma in a tertiary referral centre in a period of 15 years and identify independent prognostic factors.
Methods
Retrospective observational study enrolling all patients with primary EAC carcinoma who underwent primary surgical treatment at the Portuguese Institute of Oncology (Lisbon) between 2004 and 2018. Epidemiological, clinical, histopathological and surgical data were retrieved from clinical records and analysed.
Results
Twenty-seven patients were identified, with a median age of 77 years (range 29–92 years) and a slight female predominance (59.3%). Squamous cell carcinoma (55.6%) was the most common histological type, followed by basal cell carcinoma (40.7%) and ceruminous adenocarcinoma (3.7%). Pittsburgh tumour staging was distributed as early stage in 51.9% (I: 40.7%; II: 11.1%) and advanced stage in 48.1% (III: 29.6%; IV: 18.5%). Median follow-up period was 21 months (interquartile-range: 47). Four patients (14.8%) showed recurrence; recurrence rate was significantly higher in individuals aged < 60 years (
p
= 0.025) and with lymphovascular invasion (
p
= 0.049). Median overall survival was 88 months and estimated 2-year and 5-year overall survival rates were both 66%. Survival rates were higher in early stage patients (
p
= 0.021) and in those without facial palsy (
p
= 0.032).
Conclusion
Based on the available evidence in this review, individuals aged < 60, facial nerve impairment, advanced stage lesions, presence of lymphovascular invasion and squamous cell carcinoma histology are all associated with poor outcome and may be considered when discussing optimal treatment strategies in patients with EAC carcinoma.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Ear Canal - pathology</subject><subject>Ear Neoplasms - pathology</subject><subject>Ear Neoplasms - surgery</subject><subject>Female</subject><subject>Head and Neck Surgery</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Staging</subject><subject>Neurosurgery</subject><subject>Observational Studies as Topic</subject><subject>Otology</subject><subject>Otorhinolaryngology</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><issn>0937-4477</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwBxhQRhbD-SuO2VBVPqRKLLAhWa7jlFRJXGxHov-ehBZGptPdPfdK9yB0SeCGAMjbCMBBYKCAIQeiMD1CU8IZx1zS_BhNQTGJOZdygs5i3ACA4IqdogmjLJdE0Cl6X3wlFzrTZKYv6-TDLrNmbK0Jtu58a-4y29RdbcfZhwnGDnwdU21jZroya3y3xsOozVJwJrWuS5nvk_Wti-fopDJNdBeHOkNvD4vX-RNevjw-z--X2DIuE1awIiQXpcplSUoKK-YcBccJoaay1JVKUF6wlSiqXDgpFLWKc1HkrJBQDR_N0PU-dxv8Z-9i0m0drWsa0znfR02ZKnLKQcoBpXvUBh9jcJXehro1YacJ6NGq3lvVg1X9Y3W4nqGrQ36_al35d_KrcQDYHojDqlu7oDe-H63G_2K_AV04gpU</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Correia-Rodrigues, Pedro</creator><creator>Ramalho, Sara</creator><creator>Montalvão, Pedro</creator><creator>Magalhães, Miguel</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5193-1188</orcidid></search><sort><creationdate>20201001</creationdate><title>External auditory canal carcinoma: clinical characteristics and long-term treatment outcomes</title><author>Correia-Rodrigues, Pedro ; Ramalho, Sara ; Montalvão, Pedro ; Magalhães, Miguel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-90b1165d967d1d20b3ee20e4112afc2ed952483b58f65e7592c9445863870f493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Ear Canal - pathology</topic><topic>Ear Neoplasms - pathology</topic><topic>Ear Neoplasms - surgery</topic><topic>Female</topic><topic>Head and Neck Surgery</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Staging</topic><topic>Neurosurgery</topic><topic>Observational Studies as Topic</topic><topic>Otology</topic><topic>Otorhinolaryngology</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Correia-Rodrigues, Pedro</creatorcontrib><creatorcontrib>Ramalho, Sara</creatorcontrib><creatorcontrib>Montalvão, Pedro</creatorcontrib><creatorcontrib>Magalhães, Miguel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of oto-rhino-laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Correia-Rodrigues, Pedro</au><au>Ramalho, Sara</au><au>Montalvão, Pedro</au><au>Magalhães, Miguel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>External auditory canal carcinoma: clinical characteristics and long-term treatment outcomes</atitle><jtitle>European archives of oto-rhino-laryngology</jtitle><stitle>Eur Arch Otorhinolaryngol</stitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>277</volume><issue>10</issue><spage>2709</spage><epage>2720</epage><pages>2709-2720</pages><issn>0937-4477</issn><eissn>1434-4726</eissn><abstract>Purpose
Evidence-based treatment recommendations for external auditory canal (EAC) carcinoma are lacking in available literature. This study aims to evaluate the clinical characteristics and long-term outcomes of EAC carcinoma in a tertiary referral centre in a period of 15 years and identify independent prognostic factors.
Methods
Retrospective observational study enrolling all patients with primary EAC carcinoma who underwent primary surgical treatment at the Portuguese Institute of Oncology (Lisbon) between 2004 and 2018. Epidemiological, clinical, histopathological and surgical data were retrieved from clinical records and analysed.
Results
Twenty-seven patients were identified, with a median age of 77 years (range 29–92 years) and a slight female predominance (59.3%). Squamous cell carcinoma (55.6%) was the most common histological type, followed by basal cell carcinoma (40.7%) and ceruminous adenocarcinoma (3.7%). Pittsburgh tumour staging was distributed as early stage in 51.9% (I: 40.7%; II: 11.1%) and advanced stage in 48.1% (III: 29.6%; IV: 18.5%). Median follow-up period was 21 months (interquartile-range: 47). Four patients (14.8%) showed recurrence; recurrence rate was significantly higher in individuals aged < 60 years (
p
= 0.025) and with lymphovascular invasion (
p
= 0.049). Median overall survival was 88 months and estimated 2-year and 5-year overall survival rates were both 66%. Survival rates were higher in early stage patients (
p
= 0.021) and in those without facial palsy (
p
= 0.032).
Conclusion
Based on the available evidence in this review, individuals aged < 60, facial nerve impairment, advanced stage lesions, presence of lymphovascular invasion and squamous cell carcinoma histology are all associated with poor outcome and may be considered when discussing optimal treatment strategies in patients with EAC carcinoma.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32367152</pmid><doi>10.1007/s00405-020-06019-2</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-5193-1188</orcidid></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Ear Canal - pathology Ear Neoplasms - pathology Ear Neoplasms - surgery Female Head and Neck Surgery Humans Medicine Medicine & Public Health Middle Aged Neoplasm Recurrence, Local - epidemiology Neoplasm Recurrence, Local - pathology Neoplasm Staging Neurosurgery Observational Studies as Topic Otology Otorhinolaryngology Retrospective Studies Treatment Outcome |
| title | External auditory canal carcinoma: clinical characteristics and long-term treatment outcomes |
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