Chronic intractable lumbosacral radicular pain, is there a remedy? Pulsed radiofrequency treatment and volumetric modifications of the lumbar dorsal root ganglia
Purpose Evaluation of clinical and radiological effects of the therapeutic outcome of CT-guided pulsed radiofrequency (PRF) treatment adjacent to the lumbar dorsal root ganglion (DRG) for patients with chronic intractable lumbosacral radicular pain in a single-center prospective longitudinal study i...
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| Veröffentlicht in: | Radiologia medica 2021, Vol.126 (1), p.124-132 |
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| creator | Tortora, Fabio Negro, Alberto Russo, Camilla Cirillo, Sossio Caranci, Ferdinando |
| description | Purpose
Evaluation of clinical and radiological effects of the therapeutic outcome of CT-guided pulsed radiofrequency (PRF) treatment adjacent to the lumbar dorsal root ganglion (DRG) for patients with chronic intractable lumbosacral radicular pain in a single-center prospective longitudinal study in order to evaluate predictive factors of safety and therapeutic success.
Materials and methods
Thirty patients, from 2016 to 2018, were enrolled (age: 42–80 aa, 66.7% men and 33.3% females) with low back pain, lumbosciatalgia and/or lumbocruralgia, resistant to previous medical and physical treatments for a period not |
| doi_str_mv | 10.1007/s11547-020-01212-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2398622356</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2487447625</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-11d1d7b36e65792ecb2480617df70ab7bb6a70e40be632cdf832f2877727d1f73</originalsourceid><addsrcrecordid>eNp9kbtuFDEUhi0EIkvgBSiQJRoKJvgyY89WCK24SZGggNry5XjjaMZebA_S5m1403h3A0gpUrnwd_7Pxz9CLym5oITId4XSoZcdYaQjlFHW3TxCKzoy0Yn1yB-jFSGcdyMX7Aw9K-WakJ5Qsn6KzjjjQnI6rtCfzVVOMVgcYs3aVm0mwNMym1S0zXrCWbtgl0lnvNMhvsWh4HoFGbDGGWZw-_f4-zIVcEcy-Qy_Foh2j2sGXWeIFevo8O_UQqHmZpqTCz5YXUOKBSd_yDsqm8OlXA7SlCre6ridgn6OnnjdBC_uznP089PHH5sv3eW3z183Hy47y-VQO0odddJwAWKQawbWsH4kgkrnJdFGGiO0JNATA4Iz6_zImWejlJJJR73k5-jNKXeXU1uhVDWHYmGadIS0FMX4ehSM8UE09PU99DotObbXqSaVfS8FGxrFTpTNqZQMXu1ymHXeK0rUoUB1KlC1AtWxQHXThl7dRS-m_e6_kb-NNYCfgNKu4hbyf_cDsbfzlKnJ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2487447625</pqid></control><display><type>article</type><title>Chronic intractable lumbosacral radicular pain, is there a remedy? Pulsed radiofrequency treatment and volumetric modifications of the lumbar dorsal root ganglia</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Tortora, Fabio ; Negro, Alberto ; Russo, Camilla ; Cirillo, Sossio ; Caranci, Ferdinando</creator><creatorcontrib>Tortora, Fabio ; Negro, Alberto ; Russo, Camilla ; Cirillo, Sossio ; Caranci, Ferdinando</creatorcontrib><description>Purpose
Evaluation of clinical and radiological effects of the therapeutic outcome of CT-guided pulsed radiofrequency (PRF) treatment adjacent to the lumbar dorsal root ganglion (DRG) for patients with chronic intractable lumbosacral radicular pain in a single-center prospective longitudinal study in order to evaluate predictive factors of safety and therapeutic success.
Materials and methods
Thirty patients, from 2016 to 2018, were enrolled (age: 42–80 aa, 66.7% men and 33.3% females) with low back pain, lumbosciatalgia and/or lumbocruralgia, resistant to previous medical and physical treatments for a period not < 3 months, failure of surgical and chemiodiscolysis with ozone oxygen therapy. Each patient was subjected to a clinical evaluation (antalgic walking, sensitive deficit, interviews with specific questionnaires: ODI, RDQ,VAS) and to a radiological evaluation with MRI examination, before and 30 days after the CT-guided PRF treatment. Measurements of the thickness of the involved and not involved DRG were taken using common postprocessing software of MRI examinations in order to have measurement parameters for comparison. We analyzed the clinical course using the paired samples
T
test in order to evaluate modification for each clinical and radiological parameter (statistical significance
p
< 0.05).
Results
Significant improvements of the clinical outcomes with a good resolution of the pain symptoms (VAS evaluation: The score fell from 68.47 to 39.17 with a difference of 29.3 and a reduction of the 42.79% in the perceived pain,
p
= 0.00000152). The thickness of DRG falls from an average media of 0.586–0.448 cm (
p
= 0.000085), with a difference of 0.138 cm and a percentage reduction of 22.30%.
Conclusions
PRF treatment of the DRG may be considered for patients with chronic severe lumbosacral radicular pain refractory to conventional medical management when other noninvasive or surgical procedures fail. It is minimally invasive, inexpensive and simple to perform with no complications.</description><identifier>ISSN: 0033-8362</identifier><identifier>EISSN: 1826-6983</identifier><identifier>DOI: 10.1007/s11547-020-01212-z</identifier><identifier>PMID: 32367318</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Correlation analysis ; Diagnostic Radiology ; Evaluation ; Female ; Ganglia ; Ganglia, Spinal ; Health services ; Humans ; Imaging ; Interventional Radiology ; Longitudinal Studies ; Low Back Pain - diagnostic imaging ; Low Back Pain - therapy ; Lumbosacral Region ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neuroradiology ; Pain ; Pain Management - methods ; Parameter modification ; Prospective Studies ; Pulsed Radiofrequency Treatment - methods ; Radiculopathy - diagnostic imaging ; Radiculopathy - therapy ; Radio frequency ; Radiography, Interventional ; Radiology ; Statistical methods ; Thickness ; Tomography, X-Ray Computed ; Ultrasound</subject><ispartof>Radiologia medica, 2021, Vol.126 (1), p.124-132</ispartof><rights>Italian Society of Medical Radiology 2020</rights><rights>Italian Society of Medical Radiology 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-11d1d7b36e65792ecb2480617df70ab7bb6a70e40be632cdf832f2877727d1f73</citedby><cites>FETCH-LOGICAL-c375t-11d1d7b36e65792ecb2480617df70ab7bb6a70e40be632cdf832f2877727d1f73</cites><orcidid>0000-0002-7904-1563</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11547-020-01212-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11547-020-01212-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32367318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tortora, Fabio</creatorcontrib><creatorcontrib>Negro, Alberto</creatorcontrib><creatorcontrib>Russo, Camilla</creatorcontrib><creatorcontrib>Cirillo, Sossio</creatorcontrib><creatorcontrib>Caranci, Ferdinando</creatorcontrib><title>Chronic intractable lumbosacral radicular pain, is there a remedy? Pulsed radiofrequency treatment and volumetric modifications of the lumbar dorsal root ganglia</title><title>Radiologia medica</title><addtitle>Radiol med</addtitle><addtitle>Radiol Med</addtitle><description>Purpose
Evaluation of clinical and radiological effects of the therapeutic outcome of CT-guided pulsed radiofrequency (PRF) treatment adjacent to the lumbar dorsal root ganglion (DRG) for patients with chronic intractable lumbosacral radicular pain in a single-center prospective longitudinal study in order to evaluate predictive factors of safety and therapeutic success.
Materials and methods
Thirty patients, from 2016 to 2018, were enrolled (age: 42–80 aa, 66.7% men and 33.3% females) with low back pain, lumbosciatalgia and/or lumbocruralgia, resistant to previous medical and physical treatments for a period not < 3 months, failure of surgical and chemiodiscolysis with ozone oxygen therapy. Each patient was subjected to a clinical evaluation (antalgic walking, sensitive deficit, interviews with specific questionnaires: ODI, RDQ,VAS) and to a radiological evaluation with MRI examination, before and 30 days after the CT-guided PRF treatment. Measurements of the thickness of the involved and not involved DRG were taken using common postprocessing software of MRI examinations in order to have measurement parameters for comparison. We analyzed the clinical course using the paired samples
T
test in order to evaluate modification for each clinical and radiological parameter (statistical significance
p
< 0.05).
Results
Significant improvements of the clinical outcomes with a good resolution of the pain symptoms (VAS evaluation: The score fell from 68.47 to 39.17 with a difference of 29.3 and a reduction of the 42.79% in the perceived pain,
p
= 0.00000152). The thickness of DRG falls from an average media of 0.586–0.448 cm (
p
= 0.000085), with a difference of 0.138 cm and a percentage reduction of 22.30%.
Conclusions
PRF treatment of the DRG may be considered for patients with chronic severe lumbosacral radicular pain refractory to conventional medical management when other noninvasive or surgical procedures fail. It is minimally invasive, inexpensive and simple to perform with no complications.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Correlation analysis</subject><subject>Diagnostic Radiology</subject><subject>Evaluation</subject><subject>Female</subject><subject>Ganglia</subject><subject>Ganglia, Spinal</subject><subject>Health services</subject><subject>Humans</subject><subject>Imaging</subject><subject>Interventional Radiology</subject><subject>Longitudinal Studies</subject><subject>Low Back Pain - diagnostic imaging</subject><subject>Low Back Pain - therapy</subject><subject>Lumbosacral Region</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neuroradiology</subject><subject>Pain</subject><subject>Pain Management - methods</subject><subject>Parameter modification</subject><subject>Prospective Studies</subject><subject>Pulsed Radiofrequency Treatment - methods</subject><subject>Radiculopathy - diagnostic imaging</subject><subject>Radiculopathy - therapy</subject><subject>Radio frequency</subject><subject>Radiography, Interventional</subject><subject>Radiology</subject><subject>Statistical methods</subject><subject>Thickness</subject><subject>Tomography, X-Ray Computed</subject><subject>Ultrasound</subject><issn>0033-8362</issn><issn>1826-6983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kbtuFDEUhi0EIkvgBSiQJRoKJvgyY89WCK24SZGggNry5XjjaMZebA_S5m1403h3A0gpUrnwd_7Pxz9CLym5oITId4XSoZcdYaQjlFHW3TxCKzoy0Yn1yB-jFSGcdyMX7Aw9K-WakJ5Qsn6KzjjjQnI6rtCfzVVOMVgcYs3aVm0mwNMym1S0zXrCWbtgl0lnvNMhvsWh4HoFGbDGGWZw-_f4-zIVcEcy-Qy_Foh2j2sGXWeIFevo8O_UQqHmZpqTCz5YXUOKBSd_yDsqm8OlXA7SlCre6ridgn6OnnjdBC_uznP089PHH5sv3eW3z183Hy47y-VQO0odddJwAWKQawbWsH4kgkrnJdFGGiO0JNATA4Iz6_zImWejlJJJR73k5-jNKXeXU1uhVDWHYmGadIS0FMX4ehSM8UE09PU99DotObbXqSaVfS8FGxrFTpTNqZQMXu1ymHXeK0rUoUB1KlC1AtWxQHXThl7dRS-m_e6_kb-NNYCfgNKu4hbyf_cDsbfzlKnJ</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Tortora, Fabio</creator><creator>Negro, Alberto</creator><creator>Russo, Camilla</creator><creator>Cirillo, Sossio</creator><creator>Caranci, Ferdinando</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7904-1563</orcidid></search><sort><creationdate>2021</creationdate><title>Chronic intractable lumbosacral radicular pain, is there a remedy? Pulsed radiofrequency treatment and volumetric modifications of the lumbar dorsal root ganglia</title><author>Tortora, Fabio ; Negro, Alberto ; Russo, Camilla ; Cirillo, Sossio ; Caranci, Ferdinando</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-11d1d7b36e65792ecb2480617df70ab7bb6a70e40be632cdf832f2877727d1f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Correlation analysis</topic><topic>Diagnostic Radiology</topic><topic>Evaluation</topic><topic>Female</topic><topic>Ganglia</topic><topic>Ganglia, Spinal</topic><topic>Health services</topic><topic>Humans</topic><topic>Imaging</topic><topic>Interventional Radiology</topic><topic>Longitudinal Studies</topic><topic>Low Back Pain - diagnostic imaging</topic><topic>Low Back Pain - therapy</topic><topic>Lumbosacral Region</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neuroradiology</topic><topic>Pain</topic><topic>Pain Management - methods</topic><topic>Parameter modification</topic><topic>Prospective Studies</topic><topic>Pulsed Radiofrequency Treatment - methods</topic><topic>Radiculopathy - diagnostic imaging</topic><topic>Radiculopathy - therapy</topic><topic>Radio frequency</topic><topic>Radiography, Interventional</topic><topic>Radiology</topic><topic>Statistical methods</topic><topic>Thickness</topic><topic>Tomography, X-Ray Computed</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tortora, Fabio</creatorcontrib><creatorcontrib>Negro, Alberto</creatorcontrib><creatorcontrib>Russo, Camilla</creatorcontrib><creatorcontrib>Cirillo, Sossio</creatorcontrib><creatorcontrib>Caranci, Ferdinando</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiologia medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tortora, Fabio</au><au>Negro, Alberto</au><au>Russo, Camilla</au><au>Cirillo, Sossio</au><au>Caranci, Ferdinando</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic intractable lumbosacral radicular pain, is there a remedy? Pulsed radiofrequency treatment and volumetric modifications of the lumbar dorsal root ganglia</atitle><jtitle>Radiologia medica</jtitle><stitle>Radiol med</stitle><addtitle>Radiol Med</addtitle><date>2021</date><risdate>2021</risdate><volume>126</volume><issue>1</issue><spage>124</spage><epage>132</epage><pages>124-132</pages><issn>0033-8362</issn><eissn>1826-6983</eissn><abstract>Purpose
Evaluation of clinical and radiological effects of the therapeutic outcome of CT-guided pulsed radiofrequency (PRF) treatment adjacent to the lumbar dorsal root ganglion (DRG) for patients with chronic intractable lumbosacral radicular pain in a single-center prospective longitudinal study in order to evaluate predictive factors of safety and therapeutic success.
Materials and methods
Thirty patients, from 2016 to 2018, were enrolled (age: 42–80 aa, 66.7% men and 33.3% females) with low back pain, lumbosciatalgia and/or lumbocruralgia, resistant to previous medical and physical treatments for a period not < 3 months, failure of surgical and chemiodiscolysis with ozone oxygen therapy. Each patient was subjected to a clinical evaluation (antalgic walking, sensitive deficit, interviews with specific questionnaires: ODI, RDQ,VAS) and to a radiological evaluation with MRI examination, before and 30 days after the CT-guided PRF treatment. Measurements of the thickness of the involved and not involved DRG were taken using common postprocessing software of MRI examinations in order to have measurement parameters for comparison. We analyzed the clinical course using the paired samples
T
test in order to evaluate modification for each clinical and radiological parameter (statistical significance
p
< 0.05).
Results
Significant improvements of the clinical outcomes with a good resolution of the pain symptoms (VAS evaluation: The score fell from 68.47 to 39.17 with a difference of 29.3 and a reduction of the 42.79% in the perceived pain,
p
= 0.00000152). The thickness of DRG falls from an average media of 0.586–0.448 cm (
p
= 0.000085), with a difference of 0.138 cm and a percentage reduction of 22.30%.
Conclusions
PRF treatment of the DRG may be considered for patients with chronic severe lumbosacral radicular pain refractory to conventional medical management when other noninvasive or surgical procedures fail. It is minimally invasive, inexpensive and simple to perform with no complications.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>32367318</pmid><doi>10.1007/s11547-020-01212-z</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7904-1563</orcidid></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Correlation analysis Diagnostic Radiology Evaluation Female Ganglia Ganglia, Spinal Health services Humans Imaging Interventional Radiology Longitudinal Studies Low Back Pain - diagnostic imaging Low Back Pain - therapy Lumbosacral Region Male Medicine Medicine & Public Health Middle Aged Neuroradiology Pain Pain Management - methods Parameter modification Prospective Studies Pulsed Radiofrequency Treatment - methods Radiculopathy - diagnostic imaging Radiculopathy - therapy Radio frequency Radiography, Interventional Radiology Statistical methods Thickness Tomography, X-Ray Computed Ultrasound |
| title | Chronic intractable lumbosacral radicular pain, is there a remedy? Pulsed radiofrequency treatment and volumetric modifications of the lumbar dorsal root ganglia |
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