22β-hydroxytingenone reduces proliferation and invasion of human melanoma cells

Melanoma is a skin cancer with high invasive potential and high lethality. Considering that quinonemethide triterpenes are described as promising anticancer agents, the aim of this study was to evaluate the effect of 22β-hydroxytingenone (22-HTG) against human melanoma cells. Alamar blue assay was p...

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Veröffentlicht in:	Toxicology in vitro 2020-08, Vol.66, p.104879-104879, Article 104879
Hauptverfasser:	Aranha, Elenn Suzany Pereira, da Silva, Emerson Lucena, Mesquita, Felipe Pantoja, de Sousa, Leilane Bentes, da Silva, Felipe Moura Araújo, Rocha, Waldireny C., Lima, Emerson Silva, Koolen, Hector Henrique Ferreira, de Moraes, Maria Elisabete Amaral, Montenegro, Raquel Carvalho, de Vasconcellos, Marne Carvalho
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antineoplastic Agents, Phytogenic - pharmacology Antitumor agents Cell Line, Tumor Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Cytotoxicity Enzymatic activity Enzyme activity Enzymes Gelatinase A Gelatinase B Humans Invasiveness L-Lactate dehydrogenase L-Lactate Dehydrogenase - metabolism Lactate dehydrogenase Lactic acid Lethality Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Melanoma Melanoma - drug therapy Melanoma - metabolism Melanoma - pathology Metabolism Quinonemethide triterpenes SK-MEL-28 Skin cancer Skin Neoplasms - drug therapy Skin Neoplasms - metabolism Skin Neoplasms - pathology Triterpenes Triterpenes - pharmacology Wound Healing - drug effects
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