Adding corticosteroids to periarticular infiltration analgesia improves the short-term analgesic effects after total knee arthroplasty: a prospective, double-blind, randomized controlled trial
Purpose Periarticular infiltration analgesia (PIA) is widely used to control postoperative pain in patients who underwent total knee arthroplasty (TKA). This study aimed to evaluate the efficacy of adding corticosteroids to the PIA cocktail for pain management in patients who underwent TKA. Methods...
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| Veröffentlicht in: | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA sports traumatology, arthroscopy : official journal of the ESSKA, 2021-03, Vol.29 (3), p.867-875 |
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| container_title | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA |
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| creator | Wang, Qiuru Tan, Gang Mohammed, Alqwbani Zhang, Yueyang Li, Donghai Chen, Liyile Kang, Pengde |
| description | Purpose
Periarticular infiltration analgesia (PIA) is widely used to control postoperative pain in patients who underwent total knee arthroplasty (TKA). This study aimed to evaluate the efficacy of adding corticosteroids to the PIA cocktail for pain management in patients who underwent TKA.
Methods
The patients were randomized to the corticosteroid or control group (double-blind). The patients in the corticosteroid group received a periarticular infiltration of an analgesic cocktail of ropivacaine, epinephrine, and dexamethasone. Dexamethasone was omitted from the cocktail in the control group. The primary outcomes were postoperative pain [assessed using a visual analog scale (VAS)], time until the administration of first rescue analgesia, morphine consumption, and postoperative inflammatory biomarkers [C-reactive protein (CRP) and interleukin-6 (IL-6)]. The secondary outcomes were functional recovery, assessed by the range of knee motion, quadriceps strength, and daily ambulation distance. The tertiary outcomes included postoperative adverse effects.
Results
The patients in the corticosteroid group had significantly lower resting VAS scores at 6 and 12 h after surgery, lower VAS scores during motion up to 24 h after surgery, and lower levels of inflammatory biomarkers. All the differences in the VAS scores between the two groups did not reach the point to be considered clinically significant. The additional use of corticosteroid significantly prolonged analgesic effects and led to lower rescue morphine consumption. The patients in the corticosteroid group had significantly better functional recovery on the first day after surgery. The two groups had a similar occurrence of adverse effects.
Conclusions
Adding corticosteroids to an analgesic cocktail for PIA could lightly improve early pain relief and accelerate recovery in the first 24 h after TKA.
Level of evidence
Randomized controlled trial, Level I. |
| doi_str_mv | 10.1007/s00167-020-06039-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2398157844</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2398157844</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-da9c2c5af5cb3a2200cdbf2f23a5d7f8e9fe5b160f43a0a7a9aeca951626dc5c3</originalsourceid><addsrcrecordid>eNp9kctuFDEQRVsIRIbAD7BAltiwSIMf_RiziyJeUiQ2sG5V2-UZB7c92O5I4ev4NCpMCBILVrZcp47Lvk3zXPDXgvPxTeFcDGPLJW_5wJVu9YNmIzql2lF148Nmw3UnW8n74aR5UsoV57Tt9OPmREk1CC23m-bnubU-7phJuXqTSsWcvC2sJnbA7OH2dA2QmY_Oh5qh-hQZRAg7LB6YXw45XSM17JGVPVlaUiz3hGHoHJpaGDgqkLdCYN8iIiP3PqdDgFJv3jJgJCoHQv01njGb1jlgOwcf7RnLEG1a_A-0NGisOYVA20rzhafNIweh4LO79bT5-v7dl4uP7eXnD58uzi9bo8a-tha0kaYH15tZgZScGzs76aSC3o5ui9phP4uBu04BhxE0oAHdi0EO1vRGnTavjl4a8_uKpU6LLwZDgIhpLZNUeiv6cdt1hL78B71Ka6YPIarTHe-VHARR8kgZenfJ6KZD9gvkm0nw6Tbf6ZjvRPlOv_OdNDW9uFOv84L2vuVPoASoI1CoFHeY_979H-0vrGm3cA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2494053261</pqid></control><display><type>article</type><title>Adding corticosteroids to periarticular infiltration analgesia improves the short-term analgesic effects after total knee arthroplasty: a prospective, double-blind, randomized controlled trial</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Wang, Qiuru ; Tan, Gang ; Mohammed, Alqwbani ; Zhang, Yueyang ; Li, Donghai ; Chen, Liyile ; Kang, Pengde</creator><creatorcontrib>Wang, Qiuru ; Tan, Gang ; Mohammed, Alqwbani ; Zhang, Yueyang ; Li, Donghai ; Chen, Liyile ; Kang, Pengde</creatorcontrib><description>Purpose
Periarticular infiltration analgesia (PIA) is widely used to control postoperative pain in patients who underwent total knee arthroplasty (TKA). This study aimed to evaluate the efficacy of adding corticosteroids to the PIA cocktail for pain management in patients who underwent TKA.
Methods
The patients were randomized to the corticosteroid or control group (double-blind). The patients in the corticosteroid group received a periarticular infiltration of an analgesic cocktail of ropivacaine, epinephrine, and dexamethasone. Dexamethasone was omitted from the cocktail in the control group. The primary outcomes were postoperative pain [assessed using a visual analog scale (VAS)], time until the administration of first rescue analgesia, morphine consumption, and postoperative inflammatory biomarkers [C-reactive protein (CRP) and interleukin-6 (IL-6)]. The secondary outcomes were functional recovery, assessed by the range of knee motion, quadriceps strength, and daily ambulation distance. The tertiary outcomes included postoperative adverse effects.
Results
The patients in the corticosteroid group had significantly lower resting VAS scores at 6 and 12 h after surgery, lower VAS scores during motion up to 24 h after surgery, and lower levels of inflammatory biomarkers. All the differences in the VAS scores between the two groups did not reach the point to be considered clinically significant. The additional use of corticosteroid significantly prolonged analgesic effects and led to lower rescue morphine consumption. The patients in the corticosteroid group had significantly better functional recovery on the first day after surgery. The two groups had a similar occurrence of adverse effects.
Conclusions
Adding corticosteroids to an analgesic cocktail for PIA could lightly improve early pain relief and accelerate recovery in the first 24 h after TKA.
Level of evidence
Randomized controlled trial, Level I.</description><identifier>ISSN: 0942-2056</identifier><identifier>EISSN: 1433-7347</identifier><identifier>DOI: 10.1007/s00167-020-06039-9</identifier><identifier>PMID: 32361928</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject><![CDATA[Aged ; Analgesia ; Analgesics ; Analgesics - administration & dosage ; Arthroplasty (knee) ; Arthroplasty, Replacement, Knee - adverse effects ; Biomarkers ; C-reactive protein ; Clinical trials ; Consumption ; Corticoids ; Corticosteroids ; Dexamethasone ; Dexamethasone - administration & dosage ; Double-Blind Method ; Double-blind studies ; Epinephrine ; Epinephrine - administration & dosage ; Female ; Glucocorticoids - administration & dosage ; Humans ; Infiltration ; Inflammation ; Injections, Intra-Articular ; Interleukin 6 ; Interleukins ; Joint replacement surgery ; Joint surgery ; Knee ; Knee Joint - surgery ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Morphine ; Morphine - administration & dosage ; Orthopedics ; Pain ; Pain Management - methods ; Pain Measurement ; Pain perception ; Pain, Postoperative - etiology ; Pain, Postoperative - prevention & control ; Prospective Studies ; Quadriceps muscle ; Recovering ; Recovery of function ; Ropivacaine ; Ropivacaine - administration & dosage ; Side effects ; Surgery ; Surgical implants ; Visual Analog Scale]]></subject><ispartof>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2021-03, Vol.29 (3), p.867-875</ispartof><rights>European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) 2020</rights><rights>European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-da9c2c5af5cb3a2200cdbf2f23a5d7f8e9fe5b160f43a0a7a9aeca951626dc5c3</citedby><cites>FETCH-LOGICAL-c375t-da9c2c5af5cb3a2200cdbf2f23a5d7f8e9fe5b160f43a0a7a9aeca951626dc5c3</cites><orcidid>0000-0002-7042-6731</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00167-020-06039-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00167-020-06039-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32361928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Qiuru</creatorcontrib><creatorcontrib>Tan, Gang</creatorcontrib><creatorcontrib>Mohammed, Alqwbani</creatorcontrib><creatorcontrib>Zhang, Yueyang</creatorcontrib><creatorcontrib>Li, Donghai</creatorcontrib><creatorcontrib>Chen, Liyile</creatorcontrib><creatorcontrib>Kang, Pengde</creatorcontrib><title>Adding corticosteroids to periarticular infiltration analgesia improves the short-term analgesic effects after total knee arthroplasty: a prospective, double-blind, randomized controlled trial</title><title>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</title><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><description>Purpose
Periarticular infiltration analgesia (PIA) is widely used to control postoperative pain in patients who underwent total knee arthroplasty (TKA). This study aimed to evaluate the efficacy of adding corticosteroids to the PIA cocktail for pain management in patients who underwent TKA.
Methods
The patients were randomized to the corticosteroid or control group (double-blind). The patients in the corticosteroid group received a periarticular infiltration of an analgesic cocktail of ropivacaine, epinephrine, and dexamethasone. Dexamethasone was omitted from the cocktail in the control group. The primary outcomes were postoperative pain [assessed using a visual analog scale (VAS)], time until the administration of first rescue analgesia, morphine consumption, and postoperative inflammatory biomarkers [C-reactive protein (CRP) and interleukin-6 (IL-6)]. The secondary outcomes were functional recovery, assessed by the range of knee motion, quadriceps strength, and daily ambulation distance. The tertiary outcomes included postoperative adverse effects.
Results
The patients in the corticosteroid group had significantly lower resting VAS scores at 6 and 12 h after surgery, lower VAS scores during motion up to 24 h after surgery, and lower levels of inflammatory biomarkers. All the differences in the VAS scores between the two groups did not reach the point to be considered clinically significant. The additional use of corticosteroid significantly prolonged analgesic effects and led to lower rescue morphine consumption. The patients in the corticosteroid group had significantly better functional recovery on the first day after surgery. The two groups had a similar occurrence of adverse effects.
Conclusions
Adding corticosteroids to an analgesic cocktail for PIA could lightly improve early pain relief and accelerate recovery in the first 24 h after TKA.
Level of evidence
Randomized controlled trial, Level I.</description><subject>Aged</subject><subject>Analgesia</subject><subject>Analgesics</subject><subject>Analgesics - administration & dosage</subject><subject>Arthroplasty (knee)</subject><subject>Arthroplasty, Replacement, Knee - adverse effects</subject><subject>Biomarkers</subject><subject>C-reactive protein</subject><subject>Clinical trials</subject><subject>Consumption</subject><subject>Corticoids</subject><subject>Corticosteroids</subject><subject>Dexamethasone</subject><subject>Dexamethasone - administration & dosage</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Epinephrine</subject><subject>Epinephrine - administration & dosage</subject><subject>Female</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Humans</subject><subject>Infiltration</subject><subject>Inflammation</subject><subject>Injections, Intra-Articular</subject><subject>Interleukin 6</subject><subject>Interleukins</subject><subject>Joint replacement surgery</subject><subject>Joint surgery</subject><subject>Knee</subject><subject>Knee Joint - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Morphine</subject><subject>Morphine - administration & dosage</subject><subject>Orthopedics</subject><subject>Pain</subject><subject>Pain Management - methods</subject><subject>Pain Measurement</subject><subject>Pain perception</subject><subject>Pain, Postoperative - etiology</subject><subject>Pain, Postoperative - prevention & control</subject><subject>Prospective Studies</subject><subject>Quadriceps muscle</subject><subject>Recovering</subject><subject>Recovery of function</subject><subject>Ropivacaine</subject><subject>Ropivacaine - administration & dosage</subject><subject>Side effects</subject><subject>Surgery</subject><subject>Surgical implants</subject><subject>Visual Analog Scale</subject><issn>0942-2056</issn><issn>1433-7347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kctuFDEQRVsIRIbAD7BAltiwSIMf_RiziyJeUiQ2sG5V2-UZB7c92O5I4ev4NCpMCBILVrZcp47Lvk3zXPDXgvPxTeFcDGPLJW_5wJVu9YNmIzql2lF148Nmw3UnW8n74aR5UsoV57Tt9OPmREk1CC23m-bnubU-7phJuXqTSsWcvC2sJnbA7OH2dA2QmY_Oh5qh-hQZRAg7LB6YXw45XSM17JGVPVlaUiz3hGHoHJpaGDgqkLdCYN8iIiP3PqdDgFJv3jJgJCoHQv01njGb1jlgOwcf7RnLEG1a_A-0NGisOYVA20rzhafNIweh4LO79bT5-v7dl4uP7eXnD58uzi9bo8a-tha0kaYH15tZgZScGzs76aSC3o5ui9phP4uBu04BhxE0oAHdi0EO1vRGnTavjl4a8_uKpU6LLwZDgIhpLZNUeiv6cdt1hL78B71Ka6YPIarTHe-VHARR8kgZenfJ6KZD9gvkm0nw6Tbf6ZjvRPlOv_OdNDW9uFOv84L2vuVPoASoI1CoFHeY_979H-0vrGm3cA</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Wang, Qiuru</creator><creator>Tan, Gang</creator><creator>Mohammed, Alqwbani</creator><creator>Zhang, Yueyang</creator><creator>Li, Donghai</creator><creator>Chen, Liyile</creator><creator>Kang, Pengde</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7042-6731</orcidid></search><sort><creationdate>20210301</creationdate><title>Adding corticosteroids to periarticular infiltration analgesia improves the short-term analgesic effects after total knee arthroplasty: a prospective, double-blind, randomized controlled trial</title><author>Wang, Qiuru ; Tan, Gang ; Mohammed, Alqwbani ; Zhang, Yueyang ; Li, Donghai ; Chen, Liyile ; Kang, Pengde</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-da9c2c5af5cb3a2200cdbf2f23a5d7f8e9fe5b160f43a0a7a9aeca951626dc5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Analgesia</topic><topic>Analgesics</topic><topic>Analgesics - administration & dosage</topic><topic>Arthroplasty (knee)</topic><topic>Arthroplasty, Replacement, Knee - adverse effects</topic><topic>Biomarkers</topic><topic>C-reactive protein</topic><topic>Clinical trials</topic><topic>Consumption</topic><topic>Corticoids</topic><topic>Corticosteroids</topic><topic>Dexamethasone</topic><topic>Dexamethasone - administration & dosage</topic><topic>Double-Blind Method</topic><topic>Double-blind studies</topic><topic>Epinephrine</topic><topic>Epinephrine - administration & dosage</topic><topic>Female</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Humans</topic><topic>Infiltration</topic><topic>Inflammation</topic><topic>Injections, Intra-Articular</topic><topic>Interleukin 6</topic><topic>Interleukins</topic><topic>Joint replacement surgery</topic><topic>Joint surgery</topic><topic>Knee</topic><topic>Knee Joint - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Morphine</topic><topic>Morphine - administration & dosage</topic><topic>Orthopedics</topic><topic>Pain</topic><topic>Pain Management - methods</topic><topic>Pain Measurement</topic><topic>Pain perception</topic><topic>Pain, Postoperative - etiology</topic><topic>Pain, Postoperative - prevention & control</topic><topic>Prospective Studies</topic><topic>Quadriceps muscle</topic><topic>Recovering</topic><topic>Recovery of function</topic><topic>Ropivacaine</topic><topic>Ropivacaine - administration & dosage</topic><topic>Side effects</topic><topic>Surgery</topic><topic>Surgical implants</topic><topic>Visual Analog Scale</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Qiuru</creatorcontrib><creatorcontrib>Tan, Gang</creatorcontrib><creatorcontrib>Mohammed, Alqwbani</creatorcontrib><creatorcontrib>Zhang, Yueyang</creatorcontrib><creatorcontrib>Li, Donghai</creatorcontrib><creatorcontrib>Chen, Liyile</creatorcontrib><creatorcontrib>Kang, Pengde</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Qiuru</au><au>Tan, Gang</au><au>Mohammed, Alqwbani</au><au>Zhang, Yueyang</au><au>Li, Donghai</au><au>Chen, Liyile</au><au>Kang, Pengde</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adding corticosteroids to periarticular infiltration analgesia improves the short-term analgesic effects after total knee arthroplasty: a prospective, double-blind, randomized controlled trial</atitle><jtitle>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</jtitle><stitle>Knee Surg Sports Traumatol Arthrosc</stitle><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>29</volume><issue>3</issue><spage>867</spage><epage>875</epage><pages>867-875</pages><issn>0942-2056</issn><eissn>1433-7347</eissn><abstract>Purpose
Periarticular infiltration analgesia (PIA) is widely used to control postoperative pain in patients who underwent total knee arthroplasty (TKA). This study aimed to evaluate the efficacy of adding corticosteroids to the PIA cocktail for pain management in patients who underwent TKA.
Methods
The patients were randomized to the corticosteroid or control group (double-blind). The patients in the corticosteroid group received a periarticular infiltration of an analgesic cocktail of ropivacaine, epinephrine, and dexamethasone. Dexamethasone was omitted from the cocktail in the control group. The primary outcomes were postoperative pain [assessed using a visual analog scale (VAS)], time until the administration of first rescue analgesia, morphine consumption, and postoperative inflammatory biomarkers [C-reactive protein (CRP) and interleukin-6 (IL-6)]. The secondary outcomes were functional recovery, assessed by the range of knee motion, quadriceps strength, and daily ambulation distance. The tertiary outcomes included postoperative adverse effects.
Results
The patients in the corticosteroid group had significantly lower resting VAS scores at 6 and 12 h after surgery, lower VAS scores during motion up to 24 h after surgery, and lower levels of inflammatory biomarkers. All the differences in the VAS scores between the two groups did not reach the point to be considered clinically significant. The additional use of corticosteroid significantly prolonged analgesic effects and led to lower rescue morphine consumption. The patients in the corticosteroid group had significantly better functional recovery on the first day after surgery. The two groups had a similar occurrence of adverse effects.
Conclusions
Adding corticosteroids to an analgesic cocktail for PIA could lightly improve early pain relief and accelerate recovery in the first 24 h after TKA.
Level of evidence
Randomized controlled trial, Level I.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32361928</pmid><doi>10.1007/s00167-020-06039-9</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7042-6731</orcidid></addata></record> |
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| identifier | ISSN: 0942-2056 |
| ispartof | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2021-03, Vol.29 (3), p.867-875 |
| issn | 0942-2056 1433-7347 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2398157844 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; SpringerNature Journals |
| subjects | Aged Analgesia Analgesics Analgesics - administration & dosage Arthroplasty (knee) Arthroplasty, Replacement, Knee - adverse effects Biomarkers C-reactive protein Clinical trials Consumption Corticoids Corticosteroids Dexamethasone Dexamethasone - administration & dosage Double-Blind Method Double-blind studies Epinephrine Epinephrine - administration & dosage Female Glucocorticoids - administration & dosage Humans Infiltration Inflammation Injections, Intra-Articular Interleukin 6 Interleukins Joint replacement surgery Joint surgery Knee Knee Joint - surgery Male Medicine Medicine & Public Health Middle Aged Morphine Morphine - administration & dosage Orthopedics Pain Pain Management - methods Pain Measurement Pain perception Pain, Postoperative - etiology Pain, Postoperative - prevention & control Prospective Studies Quadriceps muscle Recovering Recovery of function Ropivacaine Ropivacaine - administration & dosage Side effects Surgery Surgical implants Visual Analog Scale |
| title | Adding corticosteroids to periarticular infiltration analgesia improves the short-term analgesic effects after total knee arthroplasty: a prospective, double-blind, randomized controlled trial |
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