Functional and structural vascular biomarkers in women 1 year after a hypertensive disorder of pregnancy
[Display omitted] •1 year after a hypertensive disorder of pregnancy (HDP): adverse pulse wave velocity (PWV) levels.•Not adverse augmentation index, carotid wall thickness, or reactive hyperemia index.•After CVD risk adjustment: no vascular function tests associated with previous HDP.•These tests u...
Gespeichert in:
| Veröffentlicht in: | Pregnancy hypertension 2020-07, Vol.21, p.23-29 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 29 |
|---|---|
| container_issue | |
| container_start_page | 23 |
| container_title | Pregnancy hypertension |
| container_volume | 21 |
| creator | Moe, Kjartan Sugulle, Meryam Dechend, Ralf Angel, Kristin Staff, Anne Cathrine |
| description | [Display omitted]
•1 year after a hypertensive disorder of pregnancy (HDP): adverse pulse wave velocity (PWV) levels.•Not adverse augmentation index, carotid wall thickness, or reactive hyperemia index.•After CVD risk adjustment: no vascular function tests associated with previous HDP.•These tests unlikely to improve cardiovascular risk assessment 1 year after HDP.•Updated preeclampsia definitions did not alter the results.
Women with a previous hypertensive disorder of pregnancy (HDP: gestational hypertension and preeclampsia) have increased long-term cardiovascular disease risk. Recent meta-analyses show adverse levels of non-invasive functional and structural cardiovascular risk markers such as pulse wave velocity (PWV), heart-rate adjusted augmentation index (AIx75), carotid intima-media thickness (CIMT), and reactive hyperemia index (RHI) after HDPs, and suggest using these for cardiovascular risk stratification. However, it is not known if a previous HDP predict levels of these markers beyond classical cardiovascular risk factors.
Study design and main outcome measures. We assessed PWV, AIx75, CIMT, RHI, classical cardiovascular risk factors, and pregnancy characteristics in 221 women 1 year postpartum (controls: 95, previous HDP: 126). Uni- and multi- variate regression analysis were conducted to assess associations between previous HDP and PWV, AIx75, CIMT or RHI. We adjusted for classical cardiovascular risk factors and pregnancy characteristics. A p-level |
| doi_str_mv | 10.1016/j.preghy.2020.04.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2398148776</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2210778920300441</els_id><sourcerecordid>2398148776</sourcerecordid><originalsourceid>FETCH-LOGICAL-c408t-a2df6baa3708defe1e1e89a2ad904af7fdc1baa8c2104296c834955f15caa083</originalsourceid><addsrcrecordid>eNp9UMFuGyEQRVWjJkrzB1XFsRdvBxbvspdKVdQklSL1kjsawxDjrsGFXVf798V1mmMZCQbmMW_eY-yDgEaA6D7vmkOm5-3SSJDQgGoA9Bt2JaWAVd8P_dvXXA-X7KaUHdSl1qD77h27bGXbiXZQV2x7N0c7hRRx5BgdL1Oe7TTnej1isfOImW9C2mP-SbnwEPnvtKfIBV-oltBPVHe-XQ6UJ4olHIm7UFJ29T15fhozYrTLe3bhcSx083Jes6e7b0-3D6vHH_ffb78-rqwCPa1QOt9tENsetCNPooYeUKIbQKHvvbOilrWt6pQcOqtbNazXXqwtIuj2mn06tz3k9GumMpl9KJbGESOluRjZDloo3fddhaoz1OZUSiZvDjlUoYsRYE4um505u2xOLhtQBv4yfHxhmDd7cq-f_nlaAV_OAKoyj4GyKTZQtORCJjsZl8L_Gf4A8HOSLA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2398148776</pqid></control><display><type>article</type><title>Functional and structural vascular biomarkers in women 1 year after a hypertensive disorder of pregnancy</title><source>Elsevier ScienceDirect Journals Complete</source><creator>Moe, Kjartan ; Sugulle, Meryam ; Dechend, Ralf ; Angel, Kristin ; Staff, Anne Cathrine</creator><creatorcontrib>Moe, Kjartan ; Sugulle, Meryam ; Dechend, Ralf ; Angel, Kristin ; Staff, Anne Cathrine</creatorcontrib><description>[Display omitted]
•1 year after a hypertensive disorder of pregnancy (HDP): adverse pulse wave velocity (PWV) levels.•Not adverse augmentation index, carotid wall thickness, or reactive hyperemia index.•After CVD risk adjustment: no vascular function tests associated with previous HDP.•These tests unlikely to improve cardiovascular risk assessment 1 year after HDP.•Updated preeclampsia definitions did not alter the results.
Women with a previous hypertensive disorder of pregnancy (HDP: gestational hypertension and preeclampsia) have increased long-term cardiovascular disease risk. Recent meta-analyses show adverse levels of non-invasive functional and structural cardiovascular risk markers such as pulse wave velocity (PWV), heart-rate adjusted augmentation index (AIx75), carotid intima-media thickness (CIMT), and reactive hyperemia index (RHI) after HDPs, and suggest using these for cardiovascular risk stratification. However, it is not known if a previous HDP predict levels of these markers beyond classical cardiovascular risk factors.
Study design and main outcome measures. We assessed PWV, AIx75, CIMT, RHI, classical cardiovascular risk factors, and pregnancy characteristics in 221 women 1 year postpartum (controls: 95, previous HDP: 126). Uni- and multi- variate regression analysis were conducted to assess associations between previous HDP and PWV, AIx75, CIMT or RHI. We adjusted for classical cardiovascular risk factors and pregnancy characteristics. A p-level < 0.05 was considered statistically significant.
PWV was associated with previous HDP on univariate analysis. This effect was confounded by blood pressure and not significant after adjustment. We found no significant associations between AIx75, RHI, CIMT, and a previous HDP, neither before nor after adjustments.
Associations between a previous HDP and PWV, AIx75, CIMT, or RHI 1 year postpartum can largely be explained by adverse levels of classical cardiovascular risk markers in women with a previous HDP. Women with previous HDP should receive primary prevention of cardiovascular disease, but PWV, AIx75, CIMT or RHI are unlikely to aid in cardiovascular risk stratification 1 year postpartum.</description><identifier>ISSN: 2210-7789</identifier><identifier>EISSN: 2210-7797</identifier><identifier>DOI: 10.1016/j.preghy.2020.04.008</identifier><identifier>PMID: 32361394</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Augmentation Index ; Cardiovascular Disease ; Carotid Intima-media Thickness ; Hypertensive Disorder of Pregnancy ; Pulse Wave Velocity ; Reactive Hyperemia Index</subject><ispartof>Pregnancy hypertension, 2020-07, Vol.21, p.23-29</ispartof><rights>2020 The Authors</rights><rights>Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-a2df6baa3708defe1e1e89a2ad904af7fdc1baa8c2104296c834955f15caa083</citedby><cites>FETCH-LOGICAL-c408t-a2df6baa3708defe1e1e89a2ad904af7fdc1baa8c2104296c834955f15caa083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.preghy.2020.04.008$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32361394$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moe, Kjartan</creatorcontrib><creatorcontrib>Sugulle, Meryam</creatorcontrib><creatorcontrib>Dechend, Ralf</creatorcontrib><creatorcontrib>Angel, Kristin</creatorcontrib><creatorcontrib>Staff, Anne Cathrine</creatorcontrib><title>Functional and structural vascular biomarkers in women 1 year after a hypertensive disorder of pregnancy</title><title>Pregnancy hypertension</title><addtitle>Pregnancy Hypertens</addtitle><description>[Display omitted]
•1 year after a hypertensive disorder of pregnancy (HDP): adverse pulse wave velocity (PWV) levels.•Not adverse augmentation index, carotid wall thickness, or reactive hyperemia index.•After CVD risk adjustment: no vascular function tests associated with previous HDP.•These tests unlikely to improve cardiovascular risk assessment 1 year after HDP.•Updated preeclampsia definitions did not alter the results.
Women with a previous hypertensive disorder of pregnancy (HDP: gestational hypertension and preeclampsia) have increased long-term cardiovascular disease risk. Recent meta-analyses show adverse levels of non-invasive functional and structural cardiovascular risk markers such as pulse wave velocity (PWV), heart-rate adjusted augmentation index (AIx75), carotid intima-media thickness (CIMT), and reactive hyperemia index (RHI) after HDPs, and suggest using these for cardiovascular risk stratification. However, it is not known if a previous HDP predict levels of these markers beyond classical cardiovascular risk factors.
Study design and main outcome measures. We assessed PWV, AIx75, CIMT, RHI, classical cardiovascular risk factors, and pregnancy characteristics in 221 women 1 year postpartum (controls: 95, previous HDP: 126). Uni- and multi- variate regression analysis were conducted to assess associations between previous HDP and PWV, AIx75, CIMT or RHI. We adjusted for classical cardiovascular risk factors and pregnancy characteristics. A p-level < 0.05 was considered statistically significant.
PWV was associated with previous HDP on univariate analysis. This effect was confounded by blood pressure and not significant after adjustment. We found no significant associations between AIx75, RHI, CIMT, and a previous HDP, neither before nor after adjustments.
Associations between a previous HDP and PWV, AIx75, CIMT, or RHI 1 year postpartum can largely be explained by adverse levels of classical cardiovascular risk markers in women with a previous HDP. Women with previous HDP should receive primary prevention of cardiovascular disease, but PWV, AIx75, CIMT or RHI are unlikely to aid in cardiovascular risk stratification 1 year postpartum.</description><subject>Augmentation Index</subject><subject>Cardiovascular Disease</subject><subject>Carotid Intima-media Thickness</subject><subject>Hypertensive Disorder of Pregnancy</subject><subject>Pulse Wave Velocity</subject><subject>Reactive Hyperemia Index</subject><issn>2210-7789</issn><issn>2210-7797</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9UMFuGyEQRVWjJkrzB1XFsRdvBxbvspdKVdQklSL1kjsawxDjrsGFXVf798V1mmMZCQbmMW_eY-yDgEaA6D7vmkOm5-3SSJDQgGoA9Bt2JaWAVd8P_dvXXA-X7KaUHdSl1qD77h27bGXbiXZQV2x7N0c7hRRx5BgdL1Oe7TTnej1isfOImW9C2mP-SbnwEPnvtKfIBV-oltBPVHe-XQ6UJ4olHIm7UFJ29T15fhozYrTLe3bhcSx083Jes6e7b0-3D6vHH_ffb78-rqwCPa1QOt9tENsetCNPooYeUKIbQKHvvbOilrWt6pQcOqtbNazXXqwtIuj2mn06tz3k9GumMpl9KJbGESOluRjZDloo3fddhaoz1OZUSiZvDjlUoYsRYE4um505u2xOLhtQBv4yfHxhmDd7cq-f_nlaAV_OAKoyj4GyKTZQtORCJjsZl8L_Gf4A8HOSLA</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Moe, Kjartan</creator><creator>Sugulle, Meryam</creator><creator>Dechend, Ralf</creator><creator>Angel, Kristin</creator><creator>Staff, Anne Cathrine</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200701</creationdate><title>Functional and structural vascular biomarkers in women 1 year after a hypertensive disorder of pregnancy</title><author>Moe, Kjartan ; Sugulle, Meryam ; Dechend, Ralf ; Angel, Kristin ; Staff, Anne Cathrine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-a2df6baa3708defe1e1e89a2ad904af7fdc1baa8c2104296c834955f15caa083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Augmentation Index</topic><topic>Cardiovascular Disease</topic><topic>Carotid Intima-media Thickness</topic><topic>Hypertensive Disorder of Pregnancy</topic><topic>Pulse Wave Velocity</topic><topic>Reactive Hyperemia Index</topic><toplevel>online_resources</toplevel><creatorcontrib>Moe, Kjartan</creatorcontrib><creatorcontrib>Sugulle, Meryam</creatorcontrib><creatorcontrib>Dechend, Ralf</creatorcontrib><creatorcontrib>Angel, Kristin</creatorcontrib><creatorcontrib>Staff, Anne Cathrine</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pregnancy hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moe, Kjartan</au><au>Sugulle, Meryam</au><au>Dechend, Ralf</au><au>Angel, Kristin</au><au>Staff, Anne Cathrine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional and structural vascular biomarkers in women 1 year after a hypertensive disorder of pregnancy</atitle><jtitle>Pregnancy hypertension</jtitle><addtitle>Pregnancy Hypertens</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>21</volume><spage>23</spage><epage>29</epage><pages>23-29</pages><issn>2210-7789</issn><eissn>2210-7797</eissn><abstract>[Display omitted]
•1 year after a hypertensive disorder of pregnancy (HDP): adverse pulse wave velocity (PWV) levels.•Not adverse augmentation index, carotid wall thickness, or reactive hyperemia index.•After CVD risk adjustment: no vascular function tests associated with previous HDP.•These tests unlikely to improve cardiovascular risk assessment 1 year after HDP.•Updated preeclampsia definitions did not alter the results.
Women with a previous hypertensive disorder of pregnancy (HDP: gestational hypertension and preeclampsia) have increased long-term cardiovascular disease risk. Recent meta-analyses show adverse levels of non-invasive functional and structural cardiovascular risk markers such as pulse wave velocity (PWV), heart-rate adjusted augmentation index (AIx75), carotid intima-media thickness (CIMT), and reactive hyperemia index (RHI) after HDPs, and suggest using these for cardiovascular risk stratification. However, it is not known if a previous HDP predict levels of these markers beyond classical cardiovascular risk factors.
Study design and main outcome measures. We assessed PWV, AIx75, CIMT, RHI, classical cardiovascular risk factors, and pregnancy characteristics in 221 women 1 year postpartum (controls: 95, previous HDP: 126). Uni- and multi- variate regression analysis were conducted to assess associations between previous HDP and PWV, AIx75, CIMT or RHI. We adjusted for classical cardiovascular risk factors and pregnancy characteristics. A p-level < 0.05 was considered statistically significant.
PWV was associated with previous HDP on univariate analysis. This effect was confounded by blood pressure and not significant after adjustment. We found no significant associations between AIx75, RHI, CIMT, and a previous HDP, neither before nor after adjustments.
Associations between a previous HDP and PWV, AIx75, CIMT, or RHI 1 year postpartum can largely be explained by adverse levels of classical cardiovascular risk markers in women with a previous HDP. Women with previous HDP should receive primary prevention of cardiovascular disease, but PWV, AIx75, CIMT or RHI are unlikely to aid in cardiovascular risk stratification 1 year postpartum.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32361394</pmid><doi>10.1016/j.preghy.2020.04.008</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2210-7789 |
| ispartof | Pregnancy hypertension, 2020-07, Vol.21, p.23-29 |
| issn | 2210-7789 2210-7797 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2398148776 |
| source | Elsevier ScienceDirect Journals Complete |
| subjects | Augmentation Index Cardiovascular Disease Carotid Intima-media Thickness Hypertensive Disorder of Pregnancy Pulse Wave Velocity Reactive Hyperemia Index |
| title | Functional and structural vascular biomarkers in women 1 year after a hypertensive disorder of pregnancy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T21%3A46%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Functional%20and%20structural%20vascular%20biomarkers%20in%20women%201%20year%20after%20a%20hypertensive%20disorder%20of%20pregnancy&rft.jtitle=Pregnancy%20hypertension&rft.au=Moe,%20Kjartan&rft.date=2020-07-01&rft.volume=21&rft.spage=23&rft.epage=29&rft.pages=23-29&rft.issn=2210-7789&rft.eissn=2210-7797&rft_id=info:doi/10.1016/j.preghy.2020.04.008&rft_dat=%3Cproquest_cross%3E2398148776%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2398148776&rft_id=info:pmid/32361394&rft_els_id=S2210778920300441&rfr_iscdi=true |