Paclitaxel Induces Immunogenic Cell Death in Ovarian Cancer via TLR4/IKK2/SNARE-Dependent Exocytosis

Emerging evidence shows that the efficacy of chemotherapeutic drugs is reliant on their capability to induce immunogenic cell death (ICD), thus transforming dying tumor cells into antitumor vaccines. We wanted to uncover potential therapeutic strategies that target ovarian cancer by having a better...

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Veröffentlicht in:	Cancer immunology research 2020-08, Vol.8 (8), p.1099-1111
Hauptverfasser:	Lau, Tat San, Chan, Loucia Kit Ying, Man, Gene Chi Wai, Wong, Chi Hang, Lee, Jacqueline Ho Sze, Yim, So Fan, Cheung, Tak Hong, McNeish, Iain A, Kwong, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Antineoplastic Agents - immunology Antineoplastic Agents - therapeutic use Cancer Vaccines - therapeutic use Cell Line, Tumor Disease Models, Animal Exocytosis Female Humans I-kappa B Kinase - immunology I-kappa B Kinase - metabolism Immunogenic Cell Death Mice Mice, Inbred C57BL Middle Aged Ovarian Neoplasms - drug therapy Ovarian Neoplasms - immunology Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Paclitaxel - immunology Paclitaxel - therapeutic use Signal Transduction SNARE Proteins - immunology SNARE Proteins - metabolism Toll-Like Receptor 4 - immunology Toll-Like Receptor 4 - metabolism
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