Modification of KL4 Peptide Revealed the Importance of Alpha-Helical Structure for Efficient siRNA Delivery

A safe and effective delivery system is considered a key to the success of nucleic acid therapeutics. It has been reported that pulmonary surfactants or their components could facilitate the uptake of small interfering RNA (siRNA) into the lung epithelial cells. Previously, our group investigated th...

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Veröffentlicht in:	Nucleic acid therapeutics 2021-06, Vol.31 (3), p.22-228
Hauptverfasser:	Qiu, Yingshan, Lo, Jason C K, Kwok, Kerry C W, Mason, A James, Lam, Jenny K W
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Amino acids Binding Cations Circular Dichroism Dichroism Efficiency Epithelial cells Epithelium Hydrophobicity Leucine Lungs Nucleic acids Original Papers Peptides Peptides - genetics Protein B Protein Conformation, alpha-Helical Protein structure Protein Structure, Secondary Residues Ribonucleic acid RNA RNA, Small Interfering - genetics Secondary structure siRNA Solubility Surfactants Transfection Valine
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