Mangiferin activates Nrf2 to attenuate cardiac fibrosis via redistributing glutaminolysis-derived glutamate

Proposed mechanism for mangiferin to restrain cardiac fibrosis. Mangiferin increases Nrf2 induction by promoting Keap1. As a result, mangiferin redistributes intracellular glutamate for the synthesis reduced glutathione (GSH), resultantly restraining cardiac myofibroblast activation by reducing glut...

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Veröffentlicht in:	Pharmacological research 2020-07, Vol.157, p.104845-104845, Article 104845
Hauptverfasser:	Song, Junna, Meng, Yunxia, Wang, Meng, Li, Lanzhu, Liu, Zhao, Zheng, Kaiyan, Wu, Lanfang, Liu, Baolin, Hou, Fangjie, Li, Aiying
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiac fibrosis Glutaminolysis Mangiferin Nrf2
Online-Zugang:	Volltext
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