Effects of Diabetic Ketoacidosis on Executive Function in Children With Type 1 Diabetes: Evidence From Wisconsin Card Sorting Test Performance
Objective Diabetic ketoacidosis (DKA) in patients with type 1 diabetes mellitus (T1DM) is known to affect memory function, but little is known about its impact on executive function. This study aimed to determine whether a history of DKA was associated with changes in executive function in children...
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| Veröffentlicht in: | Psychosomatic medicine 2020-05, Vol.82 (4), p.359-365 |
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| container_title | Psychosomatic medicine |
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| creator | He, Jing Zhu, Jiang Xie, Yuting Du, Hongyu Li, Shichen Li, Sihui He, Wenjuan Li, Xia Zhou, Zhiguang Zhu, Xiongzhao |
| description | Objective
Diabetic ketoacidosis (DKA) in patients with type 1 diabetes mellitus (T1DM) is known to affect memory function, but little is known about its impact on executive function. This study aimed to determine whether a history of DKA was associated with changes in executive function in children with T1DM.
Methods
The sample consisted of 99 patients with T1DM with histories of DKA, 82 patients with T1DM without DKA, and 100 healthy controls aged 7 to 18 years. Neuropsychological function and emotion assessments were performed in all participants. The Wisconsin Card Sorting Test (WCST) was used to assess executive function.
Results
Compared with healthy controls, the DKA group (but not the non-DKA group) had a significantly lower mean intelligence quotient (IQ; p = .006, Cohen d = 0.528) and a significantly higher rate of WCST perseverative errors (p = .006, Cohen d = 0.475). In the DKA group, the age at DKA onset was significantly associated with the IQ (p = .001) and the number of completed WCST categories (p = .046). Higher hemoglobin A1c levels were associated significantly with lower IQ (p < .001), increased rate of WCST perseverative errors (p = .015), and completion of fewer WCST categories (p = .027).
Conclusions
DKA has implications for executive function in children with T1DM. These findings emphasize the importance of DKA prevention in patients with known T1DM, especially younger children with newly diagnosed T1DM. |
| doi_str_mv | 10.1097/PSY.0000000000000797 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2397666593</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2397666593</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3803-b9e2043317b1eb4e0ae06a98049647fd0a9675254c14babd956e454c4d2721f43</originalsourceid><addsrcrecordid>eNqNkcFu1DAQhi0EokvhDRCyxAUJpTi2E8fcqrAFRCUqdRHiFDnOhHXJxovtdOlL8MxM2KWgnvDFmvE3v_7xT8jTnJ3kTKtXF5dfTti_R2l1jyzyQshMKV3eJwvGhMhEruQReRTjFTJSC_6QHAkuikpwuSA_l30PNkXqe_rGmRaSs_QDJG-s63x0-DDS5Q-wU3LXQM-m0SaHLTfSeu2GLsBIP7u0pqubLdD8oAHxNV1euw5GizPBb5CJ1o9xHjOho5c-JDd-pSuIiV5A6H3YGIQfkwe9GSI8OdzH5NPZclW_y84_vn1fn55nVlRMZK0GzqTA1docWgnMACuNrnC_Uqq-Y0aXquCFtLlsTdvpogSJley44nkvxTF5sdfdBv99QhPNBg3CMJgR_BQbLrQqy7LQAtHnd9ArP4UR3c2UrhTXTCEl95QNPsYAfbMNbmPCTZOzZs6rwbyau3nh2LOD-NRuoLsd-hMQAi_3wA5a30fr5i-9xVAF4xZSiVmQI139P127ZOYsaz-N6e8COz8kCPHbMO0gNGswQ1r_Nl5WkmeccVTBKptbQvwCQNe_5w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2399872907</pqid></control><display><type>article</type><title>Effects of Diabetic Ketoacidosis on Executive Function in Children With Type 1 Diabetes: Evidence From Wisconsin Card Sorting Test Performance</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>Web of Science - Social Sciences Citation Index – 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>He, Jing ; Zhu, Jiang ; Xie, Yuting ; Du, Hongyu ; Li, Shichen ; Li, Sihui ; He, Wenjuan ; Li, Xia ; Zhou, Zhiguang ; Zhu, Xiongzhao</creator><creatorcontrib>He, Jing ; Zhu, Jiang ; Xie, Yuting ; Du, Hongyu ; Li, Shichen ; Li, Sihui ; He, Wenjuan ; Li, Xia ; Zhou, Zhiguang ; Zhu, Xiongzhao</creatorcontrib><description>Objective
Diabetic ketoacidosis (DKA) in patients with type 1 diabetes mellitus (T1DM) is known to affect memory function, but little is known about its impact on executive function. This study aimed to determine whether a history of DKA was associated with changes in executive function in children with T1DM.
Methods
The sample consisted of 99 patients with T1DM with histories of DKA, 82 patients with T1DM without DKA, and 100 healthy controls aged 7 to 18 years. Neuropsychological function and emotion assessments were performed in all participants. The Wisconsin Card Sorting Test (WCST) was used to assess executive function.
Results
Compared with healthy controls, the DKA group (but not the non-DKA group) had a significantly lower mean intelligence quotient (IQ; p = .006, Cohen d = 0.528) and a significantly higher rate of WCST perseverative errors (p = .006, Cohen d = 0.475). In the DKA group, the age at DKA onset was significantly associated with the IQ (p = .001) and the number of completed WCST categories (p = .046). Higher hemoglobin A1c levels were associated significantly with lower IQ (p < .001), increased rate of WCST perseverative errors (p = .015), and completion of fewer WCST categories (p = .027).
Conclusions
DKA has implications for executive function in children with T1DM. These findings emphasize the importance of DKA prevention in patients with known T1DM, especially younger children with newly diagnosed T1DM.</description><identifier>ISSN: 0033-3174</identifier><identifier>EISSN: 1534-7796</identifier><identifier>DOI: 10.1097/PSY.0000000000000797</identifier><identifier>PMID: 32358324</identifier><language>eng</language><publisher>PHILADELPHIA: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Case-Control Studies ; Child ; Children ; China ; Cognition ; Diabetes ; Diabetes mellitus (insulin dependent) ; Diabetes Mellitus, Type 1 - complications ; Diabetic ketoacidosis ; Diabetic Ketoacidosis - complications ; Diabetic Ketoacidosis - psychology ; Executive function ; Executive Function - physiology ; Female ; Hemoglobin ; Humans ; Intelligence ; Intelligence tests ; Ketoacidosis ; Life Sciences & Biomedicine ; Male ; Memory ; Newly diagnosed ; Psychiatry ; Psychology ; Psychology, Multidisciplinary ; Science & Technology ; Social Sciences ; Type 1 diabetes mellitus ; Wisconsin Card Sorting Test</subject><ispartof>Psychosomatic medicine, 2020-05, Vol.82 (4), p.359-365</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright Lippincott Williams & Wilkins Ovid Technologies May 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>4</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000534347300002</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c3803-b9e2043317b1eb4e0ae06a98049647fd0a9675254c14babd956e454c4d2721f43</citedby><cites>FETCH-LOGICAL-c3803-b9e2043317b1eb4e0ae06a98049647fd0a9675254c14babd956e454c4d2721f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929,28252,28253,31003</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32358324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Jing</creatorcontrib><creatorcontrib>Zhu, Jiang</creatorcontrib><creatorcontrib>Xie, Yuting</creatorcontrib><creatorcontrib>Du, Hongyu</creatorcontrib><creatorcontrib>Li, Shichen</creatorcontrib><creatorcontrib>Li, Sihui</creatorcontrib><creatorcontrib>He, Wenjuan</creatorcontrib><creatorcontrib>Li, Xia</creatorcontrib><creatorcontrib>Zhou, Zhiguang</creatorcontrib><creatorcontrib>Zhu, Xiongzhao</creatorcontrib><title>Effects of Diabetic Ketoacidosis on Executive Function in Children With Type 1 Diabetes: Evidence From Wisconsin Card Sorting Test Performance</title><title>Psychosomatic medicine</title><addtitle>PSYCHOSOM MED</addtitle><addtitle>Psychosom Med</addtitle><description>Objective
Diabetic ketoacidosis (DKA) in patients with type 1 diabetes mellitus (T1DM) is known to affect memory function, but little is known about its impact on executive function. This study aimed to determine whether a history of DKA was associated with changes in executive function in children with T1DM.
Methods
The sample consisted of 99 patients with T1DM with histories of DKA, 82 patients with T1DM without DKA, and 100 healthy controls aged 7 to 18 years. Neuropsychological function and emotion assessments were performed in all participants. The Wisconsin Card Sorting Test (WCST) was used to assess executive function.
Results
Compared with healthy controls, the DKA group (but not the non-DKA group) had a significantly lower mean intelligence quotient (IQ; p = .006, Cohen d = 0.528) and a significantly higher rate of WCST perseverative errors (p = .006, Cohen d = 0.475). In the DKA group, the age at DKA onset was significantly associated with the IQ (p = .001) and the number of completed WCST categories (p = .046). Higher hemoglobin A1c levels were associated significantly with lower IQ (p < .001), increased rate of WCST perseverative errors (p = .015), and completion of fewer WCST categories (p = .027).
Conclusions
DKA has implications for executive function in children with T1DM. These findings emphasize the importance of DKA prevention in patients with known T1DM, especially younger children with newly diagnosed T1DM.</description><subject>Adolescent</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Children</subject><subject>China</subject><subject>Cognition</subject><subject>Diabetes</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetic ketoacidosis</subject><subject>Diabetic Ketoacidosis - complications</subject><subject>Diabetic Ketoacidosis - psychology</subject><subject>Executive function</subject><subject>Executive Function - physiology</subject><subject>Female</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Intelligence</subject><subject>Intelligence tests</subject><subject>Ketoacidosis</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Memory</subject><subject>Newly diagnosed</subject><subject>Psychiatry</subject><subject>Psychology</subject><subject>Psychology, Multidisciplinary</subject><subject>Science & Technology</subject><subject>Social Sciences</subject><subject>Type 1 diabetes mellitus</subject><subject>Wisconsin Card Sorting Test</subject><issn>0033-3174</issn><issn>1534-7796</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ARHDP</sourceid><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkcFu1DAQhi0EokvhDRCyxAUJpTi2E8fcqrAFRCUqdRHiFDnOhHXJxovtdOlL8MxM2KWgnvDFmvE3v_7xT8jTnJ3kTKtXF5dfTti_R2l1jyzyQshMKV3eJwvGhMhEruQReRTjFTJSC_6QHAkuikpwuSA_l30PNkXqe_rGmRaSs_QDJG-s63x0-DDS5Q-wU3LXQM-m0SaHLTfSeu2GLsBIP7u0pqubLdD8oAHxNV1euw5GizPBb5CJ1o9xHjOho5c-JDd-pSuIiV5A6H3YGIQfkwe9GSI8OdzH5NPZclW_y84_vn1fn55nVlRMZK0GzqTA1docWgnMACuNrnC_Uqq-Y0aXquCFtLlsTdvpogSJley44nkvxTF5sdfdBv99QhPNBg3CMJgR_BQbLrQqy7LQAtHnd9ArP4UR3c2UrhTXTCEl95QNPsYAfbMNbmPCTZOzZs6rwbyau3nh2LOD-NRuoLsd-hMQAi_3wA5a30fr5i-9xVAF4xZSiVmQI139P127ZOYsaz-N6e8COz8kCPHbMO0gNGswQ1r_Nl5WkmeccVTBKptbQvwCQNe_5w</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>He, Jing</creator><creator>Zhu, Jiang</creator><creator>Xie, Yuting</creator><creator>Du, Hongyu</creator><creator>Li, Shichen</creator><creator>Li, Sihui</creator><creator>He, Wenjuan</creator><creator>Li, Xia</creator><creator>Zhou, Zhiguang</creator><creator>Zhu, Xiongzhao</creator><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>17B</scope><scope>AOWDO</scope><scope>ARHDP</scope><scope>BLEPL</scope><scope>DTL</scope><scope>DVR</scope><scope>EGQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20200501</creationdate><title>Effects of Diabetic Ketoacidosis on Executive Function in Children With Type 1 Diabetes: Evidence From Wisconsin Card Sorting Test Performance</title><author>He, Jing ; Zhu, Jiang ; Xie, Yuting ; Du, Hongyu ; Li, Shichen ; Li, Sihui ; He, Wenjuan ; Li, Xia ; Zhou, Zhiguang ; Zhu, Xiongzhao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3803-b9e2043317b1eb4e0ae06a98049647fd0a9675254c14babd956e454c4d2721f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Children</topic><topic>China</topic><topic>Cognition</topic><topic>Diabetes</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetic ketoacidosis</topic><topic>Diabetic Ketoacidosis - complications</topic><topic>Diabetic Ketoacidosis - psychology</topic><topic>Executive function</topic><topic>Executive Function - physiology</topic><topic>Female</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Intelligence</topic><topic>Intelligence tests</topic><topic>Ketoacidosis</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Memory</topic><topic>Newly diagnosed</topic><topic>Psychiatry</topic><topic>Psychology</topic><topic>Psychology, Multidisciplinary</topic><topic>Science & Technology</topic><topic>Social Sciences</topic><topic>Type 1 diabetes mellitus</topic><topic>Wisconsin Card Sorting Test</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Jing</creatorcontrib><creatorcontrib>Zhu, Jiang</creatorcontrib><creatorcontrib>Xie, Yuting</creatorcontrib><creatorcontrib>Du, Hongyu</creatorcontrib><creatorcontrib>Li, Shichen</creatorcontrib><creatorcontrib>Li, Sihui</creatorcontrib><creatorcontrib>He, Wenjuan</creatorcontrib><creatorcontrib>Li, Xia</creatorcontrib><creatorcontrib>Zhou, Zhiguang</creatorcontrib><creatorcontrib>Zhu, Xiongzhao</creatorcontrib><collection>Web of Knowledge</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science - Social Sciences Citation Index – 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Social Sciences Citation Index</collection><collection>Web of Science Primary (SCIE, SSCI & AHCI)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Psychosomatic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Jing</au><au>Zhu, Jiang</au><au>Xie, Yuting</au><au>Du, Hongyu</au><au>Li, Shichen</au><au>Li, Sihui</au><au>He, Wenjuan</au><au>Li, Xia</au><au>Zhou, Zhiguang</au><au>Zhu, Xiongzhao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Diabetic Ketoacidosis on Executive Function in Children With Type 1 Diabetes: Evidence From Wisconsin Card Sorting Test Performance</atitle><jtitle>Psychosomatic medicine</jtitle><stitle>PSYCHOSOM MED</stitle><addtitle>Psychosom Med</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>82</volume><issue>4</issue><spage>359</spage><epage>365</epage><pages>359-365</pages><issn>0033-3174</issn><eissn>1534-7796</eissn><abstract>Objective
Diabetic ketoacidosis (DKA) in patients with type 1 diabetes mellitus (T1DM) is known to affect memory function, but little is known about its impact on executive function. This study aimed to determine whether a history of DKA was associated with changes in executive function in children with T1DM.
Methods
The sample consisted of 99 patients with T1DM with histories of DKA, 82 patients with T1DM without DKA, and 100 healthy controls aged 7 to 18 years. Neuropsychological function and emotion assessments were performed in all participants. The Wisconsin Card Sorting Test (WCST) was used to assess executive function.
Results
Compared with healthy controls, the DKA group (but not the non-DKA group) had a significantly lower mean intelligence quotient (IQ; p = .006, Cohen d = 0.528) and a significantly higher rate of WCST perseverative errors (p = .006, Cohen d = 0.475). In the DKA group, the age at DKA onset was significantly associated with the IQ (p = .001) and the number of completed WCST categories (p = .046). Higher hemoglobin A1c levels were associated significantly with lower IQ (p < .001), increased rate of WCST perseverative errors (p = .015), and completion of fewer WCST categories (p = .027).
Conclusions
DKA has implications for executive function in children with T1DM. These findings emphasize the importance of DKA prevention in patients with known T1DM, especially younger children with newly diagnosed T1DM.</abstract><cop>PHILADELPHIA</cop><pub>Lippincott Williams & Wilkins</pub><pmid>32358324</pmid><doi>10.1097/PSY.0000000000000797</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Case-Control Studies Child Children China Cognition Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - complications Diabetic ketoacidosis Diabetic Ketoacidosis - complications Diabetic Ketoacidosis - psychology Executive function Executive Function - physiology Female Hemoglobin Humans Intelligence Intelligence tests Ketoacidosis Life Sciences & Biomedicine Male Memory Newly diagnosed Psychiatry Psychology Psychology, Multidisciplinary Science & Technology Social Sciences Type 1 diabetes mellitus Wisconsin Card Sorting Test |
| title | Effects of Diabetic Ketoacidosis on Executive Function in Children With Type 1 Diabetes: Evidence From Wisconsin Card Sorting Test Performance |
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