Improved production of GTKO/hCD55/hCD59 triple-gene-modified Diannan miniature pigs for xenotransplantation by recloning

Multiple genetic modification is necessary for successful xenotransplantation from pigs. However, multiple-genetically modified cells usually suffer from various drug selections and long-term in vitro culture, which have a poor performance for somatic cell nuclear transfer (SCNT) to produce genetica...

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Veröffentlicht in:	Transgenic research 2020-06, Vol.29 (3), p.369-379
Hauptverfasser:	Zhao, Heng, Li, Yuying, Wiriyahdamrong, Thanapa, Yuan, Zaimei, Qing, Yubo, Li, Honghui, Xu, Kaixiang, Guo, Jianxiong, Jia, Baoyu, Zhang, Xuezeng, Cheng, Wenmin, Su, Yanhua, Long, Weihu, Wang, Jing, Zou, Di, Kinoshita, Keji, Zhao, Hong-Ye, Wei, Hong-Jiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Biomedical and Life Sciences Biomedical Engineering/Biotechnology Brief Communication Cell culture Cell lines Cloning Cytolysis Fetuses Fibroblasts Genetic Engineering Hogs Life Sciences Molecular Medicine Nuclear transfer Plant Genetics and Genomics Somatic cell nuclear transfer Transgenics Xenografts Xenotransplantation
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