Longitudinal Change of Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies in Patients with Coronavirus Disease 2019
Abstract Background A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently emerged and caused the rapid spread of coronavirus disease 2019 (COVID-19) worldwide. Methods We did a retrospective study and included COVID-19 patients admitted to Renmin Hospital of...
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| Veröffentlicht in: | The Journal of infectious diseases 2020-06, Vol.222 (2), p.183-188 |
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| container_title | The Journal of infectious diseases |
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| creator | Zhang, Guoxin Nie, Shuke Zhang, Zhaohui Zhang, Zhentao |
| description | Abstract
Background
A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently emerged and caused the rapid spread of coronavirus disease 2019 (COVID-19) worldwide.
Methods
We did a retrospective study and included COVID-19 patients admitted to Renmin Hospital of Wuhan University between 1 February and 29 February 2020. Antibody assay was conducted to detect COVID-19 envelope protein E and nucleocapsid protein N antigen.
Results
One hundred twelve patients were recruited with symptoms of fever, cough, fatigue, myalgia, and diarrhea. All patients underwent antibody tests. Fifty-eight (51.79%) were positive for both immunoglobulin M (IgM) and immunoglobulin G (IgG), 7 (6.25%) were negative for both antibodies, 1 (0.89%) was positive for only IgM, and 46 (41.07%) were positive for only IgG. IgM antibody appeared within a week post–disease onset, lasted for 1 month, and gradually decreased, whereas IgG antibody was produced 10 days after infection and lasted for a longer time. However, no significant difference in levels of IgM and IgG antibodies between positive and negative patients of nucleic acid test after treatment was found.
Conclusions
Our results indicate that serological tests could be a powerful approach for the early diagnosis of COVID-19.
Serological tests could be a powerful approach for the early diagnosis of COVID-19. Combining nuclear acid tests and antibody tests can, to some extent, track disease progression. |
| doi_str_mv | 10.1093/infdis/jiaa229 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2397661327</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/infdis/jiaa229</oup_id><sourcerecordid>2397661327</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-5c1626011bb3d89d2ed3ae798c9e03d555bd69febfc4d9da87d99bef0c8de03f3</originalsourceid><addsrcrecordid>eNqF0UtPAjEUBeDGaATRrUvTxI0uBvqYV5cEnwmJRnQ96UzvQAm02HYwxD_vENBEN67u5rtncQ5C55T0KRF8oE2ttB_MtZSMiQPUpQnPojSl_BB1CWEsorkQHXTi_ZwQEvM0O0YdzniSiyTtos-xNVMdGqWNXODRTJopYFvjCazBAR5WTQD8An6lnQzWbfBkY5SzS8Aj66yRa-0ajxkemqBLqzR4rA1-lkGDCR5_6DD7JW-0B-kBM0LFKTqq5cLD2f720Nvd7evoIRo_3T-OhuOoilkSoqSiKUsJpWXJVS4UA8UlZCKvBBCukiQpVSpqKOsqVkLJPFNClFCTKlctqHkPXe1yV86-N-BDsdS-gsVCGrCNLxgX2bYxlrX08g-d28a11bQqjgVloi2uVf2dqpz13kFdrJxeSrcpKCm2sxS7WYr9LO3DxT62KZegfvj3Di243gHbrP4L-wKN7Zqj</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2449129358</pqid></control><display><type>article</type><title>Longitudinal Change of Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies in Patients with Coronavirus Disease 2019</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Zhang, Guoxin ; Nie, Shuke ; Zhang, Zhaohui ; Zhang, Zhentao</creator><creatorcontrib>Zhang, Guoxin ; Nie, Shuke ; Zhang, Zhaohui ; Zhang, Zhentao</creatorcontrib><description>Abstract
Background
A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently emerged and caused the rapid spread of coronavirus disease 2019 (COVID-19) worldwide.
Methods
We did a retrospective study and included COVID-19 patients admitted to Renmin Hospital of Wuhan University between 1 February and 29 February 2020. Antibody assay was conducted to detect COVID-19 envelope protein E and nucleocapsid protein N antigen.
Results
One hundred twelve patients were recruited with symptoms of fever, cough, fatigue, myalgia, and diarrhea. All patients underwent antibody tests. Fifty-eight (51.79%) were positive for both immunoglobulin M (IgM) and immunoglobulin G (IgG), 7 (6.25%) were negative for both antibodies, 1 (0.89%) was positive for only IgM, and 46 (41.07%) were positive for only IgG. IgM antibody appeared within a week post–disease onset, lasted for 1 month, and gradually decreased, whereas IgG antibody was produced 10 days after infection and lasted for a longer time. However, no significant difference in levels of IgM and IgG antibodies between positive and negative patients of nucleic acid test after treatment was found.
Conclusions
Our results indicate that serological tests could be a powerful approach for the early diagnosis of COVID-19.
Serological tests could be a powerful approach for the early diagnosis of COVID-19. Combining nuclear acid tests and antibody tests can, to some extent, track disease progression.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiaa229</identifier><identifier>PMID: 32358956</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adult ; Aged ; Antibodies ; Antibodies, Viral - blood ; Betacoronavirus - immunology ; Clinical Laboratory Techniques ; Coronaviridae ; Coronavirus Infections - diagnosis ; Coronavirus Infections - immunology ; Coronaviruses ; Cough ; COVID-19 ; COVID-19 Testing ; Diarrhea ; Disease Progression ; Female ; Fever ; Humans ; Immunoglobulin G ; Immunoglobulin G - blood ; Immunoglobulin M ; Immunoglobulin M - blood ; Immunoglobulins ; Male ; Middle Aged ; Myalgia ; Nucleocapsids ; Pandemics ; Patients ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - immunology ; Retrospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Serologic Tests ; Serological tests ; Severe acute respiratory syndrome coronavirus 2 ; Viral envelope proteins</subject><ispartof>The Journal of infectious diseases, 2020-06, Vol.222 (2), p.183-188</ispartof><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-5c1626011bb3d89d2ed3ae798c9e03d555bd69febfc4d9da87d99bef0c8de03f3</citedby><cites>FETCH-LOGICAL-c425t-5c1626011bb3d89d2ed3ae798c9e03d555bd69febfc4d9da87d99bef0c8de03f3</cites><orcidid>0000-0002-9560-3896</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1583,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32358956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Guoxin</creatorcontrib><creatorcontrib>Nie, Shuke</creatorcontrib><creatorcontrib>Zhang, Zhaohui</creatorcontrib><creatorcontrib>Zhang, Zhentao</creatorcontrib><title>Longitudinal Change of Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies in Patients with Coronavirus Disease 2019</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Abstract
Background
A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently emerged and caused the rapid spread of coronavirus disease 2019 (COVID-19) worldwide.
Methods
We did a retrospective study and included COVID-19 patients admitted to Renmin Hospital of Wuhan University between 1 February and 29 February 2020. Antibody assay was conducted to detect COVID-19 envelope protein E and nucleocapsid protein N antigen.
Results
One hundred twelve patients were recruited with symptoms of fever, cough, fatigue, myalgia, and diarrhea. All patients underwent antibody tests. Fifty-eight (51.79%) were positive for both immunoglobulin M (IgM) and immunoglobulin G (IgG), 7 (6.25%) were negative for both antibodies, 1 (0.89%) was positive for only IgM, and 46 (41.07%) were positive for only IgG. IgM antibody appeared within a week post–disease onset, lasted for 1 month, and gradually decreased, whereas IgG antibody was produced 10 days after infection and lasted for a longer time. However, no significant difference in levels of IgM and IgG antibodies between positive and negative patients of nucleic acid test after treatment was found.
Conclusions
Our results indicate that serological tests could be a powerful approach for the early diagnosis of COVID-19.
Serological tests could be a powerful approach for the early diagnosis of COVID-19. Combining nuclear acid tests and antibody tests can, to some extent, track disease progression.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies</subject><subject>Antibodies, Viral - blood</subject><subject>Betacoronavirus - immunology</subject><subject>Clinical Laboratory Techniques</subject><subject>Coronaviridae</subject><subject>Coronavirus Infections - diagnosis</subject><subject>Coronavirus Infections - immunology</subject><subject>Coronaviruses</subject><subject>Cough</subject><subject>COVID-19</subject><subject>COVID-19 Testing</subject><subject>Diarrhea</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Fever</subject><subject>Humans</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin M</subject><subject>Immunoglobulin M - blood</subject><subject>Immunoglobulins</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myalgia</subject><subject>Nucleocapsids</subject><subject>Pandemics</subject><subject>Patients</subject><subject>Pneumonia, Viral - diagnosis</subject><subject>Pneumonia, Viral - immunology</subject><subject>Retrospective Studies</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>SARS-CoV-2</subject><subject>Serologic Tests</subject><subject>Serological tests</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Viral envelope proteins</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0UtPAjEUBeDGaATRrUvTxI0uBvqYV5cEnwmJRnQ96UzvQAm02HYwxD_vENBEN67u5rtncQ5C55T0KRF8oE2ttB_MtZSMiQPUpQnPojSl_BB1CWEsorkQHXTi_ZwQEvM0O0YdzniSiyTtos-xNVMdGqWNXODRTJopYFvjCazBAR5WTQD8An6lnQzWbfBkY5SzS8Aj66yRa-0ajxkemqBLqzR4rA1-lkGDCR5_6DD7JW-0B-kBM0LFKTqq5cLD2f720Nvd7evoIRo_3T-OhuOoilkSoqSiKUsJpWXJVS4UA8UlZCKvBBCukiQpVSpqKOsqVkLJPFNClFCTKlctqHkPXe1yV86-N-BDsdS-gsVCGrCNLxgX2bYxlrX08g-d28a11bQqjgVloi2uVf2dqpz13kFdrJxeSrcpKCm2sxS7WYr9LO3DxT62KZegfvj3Di243gHbrP4L-wKN7Zqj</recordid><startdate>20200629</startdate><enddate>20200629</enddate><creator>Zhang, Guoxin</creator><creator>Nie, Shuke</creator><creator>Zhang, Zhaohui</creator><creator>Zhang, Zhentao</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9560-3896</orcidid></search><sort><creationdate>20200629</creationdate><title>Longitudinal Change of Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies in Patients with Coronavirus Disease 2019</title><author>Zhang, Guoxin ; Nie, Shuke ; Zhang, Zhaohui ; Zhang, Zhentao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-5c1626011bb3d89d2ed3ae798c9e03d555bd69febfc4d9da87d99bef0c8de03f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies</topic><topic>Antibodies, Viral - blood</topic><topic>Betacoronavirus - immunology</topic><topic>Clinical Laboratory Techniques</topic><topic>Coronaviridae</topic><topic>Coronavirus Infections - diagnosis</topic><topic>Coronavirus Infections - immunology</topic><topic>Coronaviruses</topic><topic>Cough</topic><topic>COVID-19</topic><topic>COVID-19 Testing</topic><topic>Diarrhea</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Fever</topic><topic>Humans</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin M</topic><topic>Immunoglobulin M - blood</topic><topic>Immunoglobulins</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myalgia</topic><topic>Nucleocapsids</topic><topic>Pandemics</topic><topic>Patients</topic><topic>Pneumonia, Viral - diagnosis</topic><topic>Pneumonia, Viral - immunology</topic><topic>Retrospective Studies</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>SARS-CoV-2</topic><topic>Serologic Tests</topic><topic>Serological tests</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Viral envelope proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Guoxin</creatorcontrib><creatorcontrib>Nie, Shuke</creatorcontrib><creatorcontrib>Zhang, Zhaohui</creatorcontrib><creatorcontrib>Zhang, Zhentao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Guoxin</au><au>Nie, Shuke</au><au>Zhang, Zhaohui</au><au>Zhang, Zhentao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal Change of Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies in Patients with Coronavirus Disease 2019</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2020-06-29</date><risdate>2020</risdate><volume>222</volume><issue>2</issue><spage>183</spage><epage>188</epage><pages>183-188</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Abstract
Background
A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently emerged and caused the rapid spread of coronavirus disease 2019 (COVID-19) worldwide.
Methods
We did a retrospective study and included COVID-19 patients admitted to Renmin Hospital of Wuhan University between 1 February and 29 February 2020. Antibody assay was conducted to detect COVID-19 envelope protein E and nucleocapsid protein N antigen.
Results
One hundred twelve patients were recruited with symptoms of fever, cough, fatigue, myalgia, and diarrhea. All patients underwent antibody tests. Fifty-eight (51.79%) were positive for both immunoglobulin M (IgM) and immunoglobulin G (IgG), 7 (6.25%) were negative for both antibodies, 1 (0.89%) was positive for only IgM, and 46 (41.07%) were positive for only IgG. IgM antibody appeared within a week post–disease onset, lasted for 1 month, and gradually decreased, whereas IgG antibody was produced 10 days after infection and lasted for a longer time. However, no significant difference in levels of IgM and IgG antibodies between positive and negative patients of nucleic acid test after treatment was found.
Conclusions
Our results indicate that serological tests could be a powerful approach for the early diagnosis of COVID-19.
Serological tests could be a powerful approach for the early diagnosis of COVID-19. Combining nuclear acid tests and antibody tests can, to some extent, track disease progression.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32358956</pmid><doi>10.1093/infdis/jiaa229</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9560-3896</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Antibodies Antibodies, Viral - blood Betacoronavirus - immunology Clinical Laboratory Techniques Coronaviridae Coronavirus Infections - diagnosis Coronavirus Infections - immunology Coronaviruses Cough COVID-19 COVID-19 Testing Diarrhea Disease Progression Female Fever Humans Immunoglobulin G Immunoglobulin G - blood Immunoglobulin M Immunoglobulin M - blood Immunoglobulins Male Middle Aged Myalgia Nucleocapsids Pandemics Patients Pneumonia, Viral - diagnosis Pneumonia, Viral - immunology Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction SARS-CoV-2 Serologic Tests Serological tests Severe acute respiratory syndrome coronavirus 2 Viral envelope proteins |
| title | Longitudinal Change of Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies in Patients with Coronavirus Disease 2019 |
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