Genomic Profiling by ALaP-Seq Reveals Transcriptional Regulation by PML Bodies through DNMT3A Exclusion

The promyelocytic leukemia (PML) body is a phase-separated nuclear structure physically associated with chromatin, implying its crucial roles in genome functions. However, its role in transcriptional regulation is largely unknown. We developed APEX-mediated chromatin labeling and purification (ALaP)...

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Veröffentlicht in:	Molecular cell 2020-05, Vol.78 (3), p.493-505.e8
Hauptverfasser:	Kurihara, Misuzu, Kato, Kagayaki, Sanbo, Chiaki, Shigenobu, Shuji, Ohkawa, Yasuyuki, Fuchigami, Takeshi, Miyanari, Yusuke
Format:	Artikel
Sprache:	eng
Schlagworte:	APEX chromatin DNA methylation phase separation PML Y chromosome
Online-Zugang:	Volltext
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