Pharmacological approaches to mitigate neuroinflammation in Alzheimer’s disease

•Although neuroinflammation is a hallmark of Alzheimer’s disease, it is unclear whether it is a cause or consequence of this pathology.•Microglia and astroglia are powerful regulators of neuroinflammatory responses in Alzheimer’s disease.•Vorinostat and ORY-2001 are two epigenetic drugs under clinic...

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Veröffentlicht in:	International immunopharmacology 2020-07, Vol.84, p.106479-106479, Article 106479
Hauptverfasser:	Uddin, Md. Sahab, Kabir, Md. Tanvir, Mamun, Abdullah Al, Barreto, George E., Rashid, Mamunur, Perveen, Asma, Ashraf, Ghulam Md
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - etiology Alzheimer Disease - metabolism Alzheimer's disease Animals Anti-inflammatory agents Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Astrocytes Clinical trials Clinical Trials as Topic Cytokines - drug effects Cytokines - immunology Cytokines - metabolism Drug development Drugs Humans Immune system Immunosuppressive agents Inflammation Inflammation - complications Inflammation - drug therapy Inflammation - metabolism Microglial cells Neurodegenerative diseases Neurofibrillary tangles Neuroglia - drug effects Neuroglia - immunology Neuroglia - metabolism Neuroinflammation Neurons - drug effects Neurons - immunology Neurons - metabolism Proinflammatory molecules Senile plaques
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