The association between the adrenergic hyperactivity and blood pressure values in people with multiple sclerosis
Objectives To evaluate the evolution of adrenergic baroreflex sensitivity (BRSa) over 2-year follow-up and to investigate the effect of baseline BRSa indices on blood pressure values after 2 years in people with multiple sclerosis (pwMS). Methods The following data were analysed at baseline and afte...
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| Veröffentlicht in: | Neurological sciences 2020-11, Vol.41 (11), p.3157-3164 |
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| creator | Habek, Mario Pucić, Dunja Mutak, Tomislav Crnošija, Luka Lovrić, Mila Krbot Skorić, Magdalena |
| description | Objectives
To evaluate the evolution of adrenergic baroreflex sensitivity (BRSa) over 2-year follow-up and to investigate the effect of baseline BRSa indices on blood pressure values after 2 years in people with multiple sclerosis (pwMS).
Methods
The following data were analysed at baseline and after 2 years: BRSa measured with BRSa1, α-BRSa and β-BRSa, supine and tilted levels of epinephrine and norepinephrine, supine and tilted systolic and diastolic blood pressure levels.
Results
Compared to baseline values, there was no change in α-BRSa (6.96 ± 2.56 vs. 6.64 ± 2.24,
p
= 0.379) at month 24. α-BRSa at month 24 positively correlated with tilted levels of norepinephrine at month 24 (
r
p
= 0.357,
p
= 0.005). Univariable linear regression analysis revealed that α-BRSa at baseline predicts the value of tilted systolic and diastolic blood pressure at month 24 (B = 2.724, 95% CI 1.357–4.091,
p
|
| doi_str_mv | 10.1007/s10072-020-04432-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2396858459</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2396858459</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-59785b7e5fa7d88334b9850416292d6cdb7a16e96b0e14b4ff564a8f44dee5d93</originalsourceid><addsrcrecordid>eNp9kD9PwzAQxS0EoqXwBRiQR5aAHduJM6KKf1IlljJbTnxpXaVxsJ1W_fYktDCy-Hznd0_PP4RuKXmghOSPYTzThKQkIZyzNGFnaEpFQRLGc3l-ulOZ8wm6CmFDCKGcsks0YSkTJMvZFHXLNWAdgqusjta1uIS4B2hxHOfGQwt-ZSu8PnTgdRXtzsYD1q3BZeOcwZ2HEHoPeKebHgK2Le7AdQ3gvY1rvO2baMcuVA14F2y4Rhe1bgLcnOoMfb48L-dvyeLj9X3-tEiqIXxMRJFLUeYgap0bKRnjZSEF4TRLi9RklSlzTTMospIA5SWva5FxLWvODYAwBZuh-6Nv593XkCyqrQ0VNI1uwfVBpazIpJBcjNL0KK2GhMFDrTpvt9ofFCVqZKyOpNVAWv2QVmxYujv59-UWzN_KL9pBwI6CMDy1K_Bq43rfDn_-z_Yb-tWLYg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2396858459</pqid></control><display><type>article</type><title>The association between the adrenergic hyperactivity and blood pressure values in people with multiple sclerosis</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Habek, Mario ; Pucić, Dunja ; Mutak, Tomislav ; Crnošija, Luka ; Lovrić, Mila ; Krbot Skorić, Magdalena</creator><creatorcontrib>Habek, Mario ; Pucić, Dunja ; Mutak, Tomislav ; Crnošija, Luka ; Lovrić, Mila ; Krbot Skorić, Magdalena</creatorcontrib><description>Objectives
To evaluate the evolution of adrenergic baroreflex sensitivity (BRSa) over 2-year follow-up and to investigate the effect of baseline BRSa indices on blood pressure values after 2 years in people with multiple sclerosis (pwMS).
Methods
The following data were analysed at baseline and after 2 years: BRSa measured with BRSa1, α-BRSa and β-BRSa, supine and tilted levels of epinephrine and norepinephrine, supine and tilted systolic and diastolic blood pressure levels.
Results
Compared to baseline values, there was no change in α-BRSa (6.96 ± 2.56 vs. 6.64 ± 2.24,
p
= 0.379) at month 24. α-BRSa at month 24 positively correlated with tilted levels of norepinephrine at month 24 (
r
p
= 0.357,
p
= 0.005). Univariable linear regression analysis revealed that α-BRSa at baseline predicts the value of tilted systolic and diastolic blood pressure at month 24 (B = 2.724, 95% CI 1.357–4.091,
p
< 0.001 and B = 1.489, 95% CI 0.459–2.519,
p
= 0.005).
Conclusion
This study provides further evidence for possible role of α-BRSa as a marker of adrenergic hyperactivity in pwMS. These results may explain increased risk for cardiovascular diseases in pwMS.</description><identifier>ISSN: 1590-1874</identifier><identifier>EISSN: 1590-3478</identifier><identifier>DOI: 10.1007/s10072-020-04432-3</identifier><identifier>PMID: 32350673</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adrenergic Agents ; Baroreflex ; Blood Pressure ; Cardiovascular Diseases ; Heart Rate ; Humans ; Hypertension ; Medicine ; Medicine & Public Health ; Multiple Sclerosis ; Neurology ; Neuroradiology ; Neurosurgery ; Original Article ; Psychiatry</subject><ispartof>Neurological sciences, 2020-11, Vol.41 (11), p.3157-3164</ispartof><rights>Fondazione Società Italiana di Neurologia 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-59785b7e5fa7d88334b9850416292d6cdb7a16e96b0e14b4ff564a8f44dee5d93</citedby><cites>FETCH-LOGICAL-c347t-59785b7e5fa7d88334b9850416292d6cdb7a16e96b0e14b4ff564a8f44dee5d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10072-020-04432-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10072-020-04432-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32350673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Habek, Mario</creatorcontrib><creatorcontrib>Pucić, Dunja</creatorcontrib><creatorcontrib>Mutak, Tomislav</creatorcontrib><creatorcontrib>Crnošija, Luka</creatorcontrib><creatorcontrib>Lovrić, Mila</creatorcontrib><creatorcontrib>Krbot Skorić, Magdalena</creatorcontrib><title>The association between the adrenergic hyperactivity and blood pressure values in people with multiple sclerosis</title><title>Neurological sciences</title><addtitle>Neurol Sci</addtitle><addtitle>Neurol Sci</addtitle><description>Objectives
To evaluate the evolution of adrenergic baroreflex sensitivity (BRSa) over 2-year follow-up and to investigate the effect of baseline BRSa indices on blood pressure values after 2 years in people with multiple sclerosis (pwMS).
Methods
The following data were analysed at baseline and after 2 years: BRSa measured with BRSa1, α-BRSa and β-BRSa, supine and tilted levels of epinephrine and norepinephrine, supine and tilted systolic and diastolic blood pressure levels.
Results
Compared to baseline values, there was no change in α-BRSa (6.96 ± 2.56 vs. 6.64 ± 2.24,
p
= 0.379) at month 24. α-BRSa at month 24 positively correlated with tilted levels of norepinephrine at month 24 (
r
p
= 0.357,
p
= 0.005). Univariable linear regression analysis revealed that α-BRSa at baseline predicts the value of tilted systolic and diastolic blood pressure at month 24 (B = 2.724, 95% CI 1.357–4.091,
p
< 0.001 and B = 1.489, 95% CI 0.459–2.519,
p
= 0.005).
Conclusion
This study provides further evidence for possible role of α-BRSa as a marker of adrenergic hyperactivity in pwMS. These results may explain increased risk for cardiovascular diseases in pwMS.</description><subject>Adrenergic Agents</subject><subject>Baroreflex</subject><subject>Blood Pressure</subject><subject>Cardiovascular Diseases</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multiple Sclerosis</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Psychiatry</subject><issn>1590-1874</issn><issn>1590-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD9PwzAQxS0EoqXwBRiQR5aAHduJM6KKf1IlljJbTnxpXaVxsJ1W_fYktDCy-Hznd0_PP4RuKXmghOSPYTzThKQkIZyzNGFnaEpFQRLGc3l-ulOZ8wm6CmFDCKGcsks0YSkTJMvZFHXLNWAdgqusjta1uIS4B2hxHOfGQwt-ZSu8PnTgdRXtzsYD1q3BZeOcwZ2HEHoPeKebHgK2Le7AdQ3gvY1rvO2baMcuVA14F2y4Rhe1bgLcnOoMfb48L-dvyeLj9X3-tEiqIXxMRJFLUeYgap0bKRnjZSEF4TRLi9RklSlzTTMospIA5SWva5FxLWvODYAwBZuh-6Nv593XkCyqrQ0VNI1uwfVBpazIpJBcjNL0KK2GhMFDrTpvt9ofFCVqZKyOpNVAWv2QVmxYujv59-UWzN_KL9pBwI6CMDy1K_Bq43rfDn_-z_Yb-tWLYg</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Habek, Mario</creator><creator>Pucić, Dunja</creator><creator>Mutak, Tomislav</creator><creator>Crnošija, Luka</creator><creator>Lovrić, Mila</creator><creator>Krbot Skorić, Magdalena</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20201101</creationdate><title>The association between the adrenergic hyperactivity and blood pressure values in people with multiple sclerosis</title><author>Habek, Mario ; Pucić, Dunja ; Mutak, Tomislav ; Crnošija, Luka ; Lovrić, Mila ; Krbot Skorić, Magdalena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-59785b7e5fa7d88334b9850416292d6cdb7a16e96b0e14b4ff564a8f44dee5d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adrenergic Agents</topic><topic>Baroreflex</topic><topic>Blood Pressure</topic><topic>Cardiovascular Diseases</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multiple Sclerosis</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosurgery</topic><topic>Original Article</topic><topic>Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Habek, Mario</creatorcontrib><creatorcontrib>Pucić, Dunja</creatorcontrib><creatorcontrib>Mutak, Tomislav</creatorcontrib><creatorcontrib>Crnošija, Luka</creatorcontrib><creatorcontrib>Lovrić, Mila</creatorcontrib><creatorcontrib>Krbot Skorić, Magdalena</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Habek, Mario</au><au>Pucić, Dunja</au><au>Mutak, Tomislav</au><au>Crnošija, Luka</au><au>Lovrić, Mila</au><au>Krbot Skorić, Magdalena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between the adrenergic hyperactivity and blood pressure values in people with multiple sclerosis</atitle><jtitle>Neurological sciences</jtitle><stitle>Neurol Sci</stitle><addtitle>Neurol Sci</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>41</volume><issue>11</issue><spage>3157</spage><epage>3164</epage><pages>3157-3164</pages><issn>1590-1874</issn><eissn>1590-3478</eissn><abstract>Objectives
To evaluate the evolution of adrenergic baroreflex sensitivity (BRSa) over 2-year follow-up and to investigate the effect of baseline BRSa indices on blood pressure values after 2 years in people with multiple sclerosis (pwMS).
Methods
The following data were analysed at baseline and after 2 years: BRSa measured with BRSa1, α-BRSa and β-BRSa, supine and tilted levels of epinephrine and norepinephrine, supine and tilted systolic and diastolic blood pressure levels.
Results
Compared to baseline values, there was no change in α-BRSa (6.96 ± 2.56 vs. 6.64 ± 2.24,
p
= 0.379) at month 24. α-BRSa at month 24 positively correlated with tilted levels of norepinephrine at month 24 (
r
p
= 0.357,
p
= 0.005). Univariable linear regression analysis revealed that α-BRSa at baseline predicts the value of tilted systolic and diastolic blood pressure at month 24 (B = 2.724, 95% CI 1.357–4.091,
p
< 0.001 and B = 1.489, 95% CI 0.459–2.519,
p
= 0.005).
Conclusion
This study provides further evidence for possible role of α-BRSa as a marker of adrenergic hyperactivity in pwMS. These results may explain increased risk for cardiovascular diseases in pwMS.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32350673</pmid><doi>10.1007/s10072-020-04432-3</doi><tpages>8</tpages></addata></record> |
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| issn | 1590-1874 1590-3478 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adrenergic Agents Baroreflex Blood Pressure Cardiovascular Diseases Heart Rate Humans Hypertension Medicine Medicine & Public Health Multiple Sclerosis Neurology Neuroradiology Neurosurgery Original Article Psychiatry |
| title | The association between the adrenergic hyperactivity and blood pressure values in people with multiple sclerosis |
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