Anthraquinone: a promising scaffold for the discovery and development of therapeutic agents in cancer therapy
Cancer, characterized by uncontrolled malignant neoplasm, is a leading cause of death in both advanced and emerging countries. Although, ample drugs are accessible in the market to intervene with tumor progression, none are totally effective and safe. Natural anthraquinone (AQ) equivalents such as e...
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| Veröffentlicht in: | Future medicinal chemistry 2020-06, Vol.12 (11), p.1037-1069 |
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| container_title | Future medicinal chemistry |
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| creator | Siddamurthi, Supraja Gutti, Gopichand Jana, Srabanti Kumar, Ashok Singh, Sushil Kumar |
| description | Cancer, characterized by uncontrolled malignant neoplasm, is a leading cause of death in both advanced and emerging countries. Although, ample drugs are accessible in the market to intervene with tumor progression, none are totally effective and safe. Natural anthraquinone (AQ) equivalents such as emodin, aloe-emodin, alchemix and many synthetic analogs extend their antitumor activity on different targets including telomerase, topoisomerases, kinases, matrix metalloproteinases, DNA and different phases of cell lines. Nano drug delivery strategies are advanced tools which deliver drugs into tumor cells with minimum drug leakage to normal cells. This review delineates the way AQ derivatives are binding on these targets by abolishing tumor cells to produce anticancer activity and purview of nanoformulations related to AQ analogs. |
| doi_str_mv | 10.4155/fmc-2019-0198 |
| format | Article |
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Although, ample drugs are accessible in the market to intervene with tumor progression, none are totally effective and safe. Natural anthraquinone (AQ) equivalents such as emodin, aloe-emodin, alchemix and many synthetic analogs extend their antitumor activity on different targets including telomerase, topoisomerases, kinases, matrix metalloproteinases, DNA and different phases of cell lines. Nano drug delivery strategies are advanced tools which deliver drugs into tumor cells with minimum drug leakage to normal cells. 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Although, ample drugs are accessible in the market to intervene with tumor progression, none are totally effective and safe. Natural anthraquinone (AQ) equivalents such as emodin, aloe-emodin, alchemix and many synthetic analogs extend their antitumor activity on different targets including telomerase, topoisomerases, kinases, matrix metalloproteinases, DNA and different phases of cell lines. Nano drug delivery strategies are advanced tools which deliver drugs into tumor cells with minimum drug leakage to normal cells. This review delineates the way AQ derivatives are binding on these targets by abolishing tumor cells to produce anticancer activity and purview of nanoformulations related to AQ analogs.</description><subject>Anthraquinone</subject><subject>Anthraquinones - chemical synthesis</subject><subject>Anthraquinones - chemistry</subject><subject>Anthraquinones - pharmacology</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antitumor activity</subject><subject>Bioavailability</subject><subject>Biological Products - chemical synthesis</subject><subject>Biological Products - chemistry</subject><subject>Biological Products - pharmacology</subject><subject>cancer</subject><subject>Cancer therapies</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Cell Proliferation</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA topoisomerase</subject><subject>DNA, Neoplasm - drug effects</subject><subject>Drug delivery</subject><subject>Drug Development</subject><subject>Drug dosages</subject><subject>Emodin</subject><subject>Enzyme Inhibitors - chemical synthesis</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Enzymes</subject><subject>Herbal medicine</subject><subject>Humans</subject><subject>Kinases</subject><subject>Laxatives</subject><subject>Matrix metalloproteinase</subject><subject>nanoparticles</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Pharmaceutical industry</subject><subject>Telomerase</subject><subject>topoisomerase</subject><subject>Tumor cells</subject><issn>1756-8919</issn><issn>1756-8927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kctrFTEUxoMottQu3UrAjZupeUxe7kpRKxTc6DpkkpM2ZSa5TWYK9783l3vtQjCQ9-98nHM-hN5TcjVSIT7HxQ-MUDP0qV-hc6qEHLRh6vXLmZozdNnaI-mDM22keIvOOOOjEYydo-U6rw_VPW0plwxfsMO7WpbUUr7HzbsYyxxwLBWvD4BDar48Q91jlwMO8Axz2S2QV1ziAahuB9uaPHb3_bHhlLF32UM9fe7foTfRzQ0uT_sF-v3t66-b2-Hu5_cfN9d3gx-5WvuqaE9Vk-D4RCfOhaScEOe5BJhAaToZHUEDdYZwKZUOjokgJypUjwv8An066vZinjZoq-0leZhnl6FszTJupBZq1LqjH_9BH8tWc8_OMkFHziRRpFPDkfK1tFYh2l1Ni6t7S4k9WGG7FfZghT1Y0fkPJ9VtWiC80H8b3wFzBOK2bhWaT9AbZY-3HpF8yvAf8T_yOpgT</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Siddamurthi, Supraja</creator><creator>Gutti, Gopichand</creator><creator>Jana, Srabanti</creator><creator>Kumar, Ashok</creator><creator>Singh, Sushil Kumar</creator><general>Newlands Press Ltd</general><general>Newlands Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0473-5824</orcidid><orcidid>https://orcid.org/0000-0002-5284-2379</orcidid></search><sort><creationdate>20200601</creationdate><title>Anthraquinone: a promising scaffold for the discovery and development of therapeutic agents in cancer therapy</title><author>Siddamurthi, Supraja ; Gutti, Gopichand ; Jana, Srabanti ; Kumar, Ashok ; Singh, Sushil Kumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-c47128980da3b1b33561300ac36eebe781b98fe8e1a9036678da25d6b157289d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anthraquinone</topic><topic>Anthraquinones - chemical synthesis</topic><topic>Anthraquinones - chemistry</topic><topic>Anthraquinones - pharmacology</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antitumor activity</topic><topic>Bioavailability</topic><topic>Biological Products - chemical synthesis</topic><topic>Biological Products - chemistry</topic><topic>Biological Products - pharmacology</topic><topic>cancer</topic><topic>Cancer therapies</topic><topic>Cell cycle</topic><topic>Cell growth</topic><topic>Cell Proliferation</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA topoisomerase</topic><topic>DNA, Neoplasm - drug effects</topic><topic>Drug delivery</topic><topic>Drug Development</topic><topic>Drug dosages</topic><topic>Emodin</topic><topic>Enzyme Inhibitors - chemical synthesis</topic><topic>Enzyme Inhibitors - chemistry</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Enzymes</topic><topic>Herbal medicine</topic><topic>Humans</topic><topic>Kinases</topic><topic>Laxatives</topic><topic>Matrix metalloproteinase</topic><topic>nanoparticles</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Pharmaceutical industry</topic><topic>Telomerase</topic><topic>topoisomerase</topic><topic>Tumor cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siddamurthi, Supraja</creatorcontrib><creatorcontrib>Gutti, Gopichand</creatorcontrib><creatorcontrib>Jana, Srabanti</creatorcontrib><creatorcontrib>Kumar, Ashok</creatorcontrib><creatorcontrib>Singh, Sushil Kumar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Future medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siddamurthi, Supraja</au><au>Gutti, Gopichand</au><au>Jana, Srabanti</au><au>Kumar, Ashok</au><au>Singh, Sushil Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anthraquinone: a promising scaffold for the discovery and development of therapeutic agents in cancer therapy</atitle><jtitle>Future medicinal chemistry</jtitle><addtitle>Future Med Chem</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>12</volume><issue>11</issue><spage>1037</spage><epage>1069</epage><pages>1037-1069</pages><issn>1756-8919</issn><eissn>1756-8927</eissn><abstract>Cancer, characterized by uncontrolled malignant neoplasm, is a leading cause of death in both advanced and emerging countries. 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| subjects | Anthraquinone Anthraquinones - chemical synthesis Anthraquinones - chemistry Anthraquinones - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Bioavailability Biological Products - chemical synthesis Biological Products - chemistry Biological Products - pharmacology cancer Cancer therapies Cell cycle Cell growth Cell Proliferation Deoxyribonucleic acid DNA DNA topoisomerase DNA, Neoplasm - drug effects Drug delivery Drug Development Drug dosages Emodin Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzymes Herbal medicine Humans Kinases Laxatives Matrix metalloproteinase nanoparticles Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Pharmaceutical industry Telomerase topoisomerase Tumor cells |
| title | Anthraquinone: a promising scaffold for the discovery and development of therapeutic agents in cancer therapy |
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