Stool Antigen Testing, a Reliable Noninvasive Method of Assessment of Helicobacter pylori Infection Among Patients with Gastro-duodenal Disorders in Cameroon
Background Several techniques such as invasive and noninvasive are used for the diagnosis of H. pylori infection. Aim The aim of this study was to compare the results of rapid urease test, stool antigen test and serology in diagnosing H. pylori infection in Cameroon. Methods Hundred patients (66 wom...
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| Veröffentlicht in: | Digestive diseases and sciences 2021-02, Vol.66 (2), p.511-520 |
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| creator | Kouitcheu Mabeku, Laure Brigitte Bello Epesse, Mohamadou Fotsing, Stephane Kamgang, Roland Tchidjo, Magloire |
| description | Background
Several techniques such as invasive and noninvasive are used for the diagnosis of
H. pylori
infection.
Aim
The aim of this study was to compare the results of rapid urease test, stool antigen test and serology in diagnosing
H. pylori
infection in Cameroon.
Methods
Hundred patients (66 women and 34 men) were enrolled. Each patient gave a written consent. The study was approved by the local Ethical Committee of Medical Sciences and the institutional review board. From each patient, blood, stool and gastric biopsies samples were collected for
H. pylori
detection using three methods: stool antigen test, serology and rapid urease test (RUT), taken as gold standard. Statistical analysis was performed using Graph pad Prism 7.
Results
Helicobacter pylori
infection was detected in 43%, 45% and 73% of patients based on the RUT, stool antigen test and serology, respectively. The difference was statistically significant between serology and RUT (
P
= 0.0026), but not between stool antigens test and RUT (
P
= 0.288). Taken RUT as gold standard, the sensitivity, specificity, positive and negative predictive values of stool antigens test and serology were 65.11, 70.17, 62.22 and 72.72%; 88.37, 40.35, 55.77 and 82.14%, respectively. The accuracy of stool antigen test and serology was 68 and 61%, respectively.
Conclusions
Our finding showed that stool antigen test can be used as a noninvasive method of assessment of
H. pylori
infection in our setting. Serological test can be used in screening; however, further diagnostic tests need to be carried out to confirm seropositive cases. |
| doi_str_mv | 10.1007/s10620-020-06219-0 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2396854455</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A712933684</galeid><sourcerecordid>A712933684</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-f5f8be8b6483fbcbe26eb063f56a65b87ca1c6a2d3f271927019d418729f7cb23</originalsourceid><addsrcrecordid>eNp9kstu1TAQhi0EoofCC7BAltiwaIoviZMsowO9SOUiKOvIdsapq8Q-tZ2iPgzviqNTqEAIWSOP7W9GM-MfoZeUHFNC6reREsFIQVYTjLYFeYQ2tKp5wSrRPEYbQkX2KRUH6FmM14SQtqbiKTrgjFekZnyDfnxN3k-4c8mO4PAlxGTdeIQl_gKTlWoC_NE7625ltLeAP0C68gP2BncxQowzuLSezjKsvZI6QcC7u8kHi8-dAZ2sd7ibvRvxZ5lsxiP-btMVPpUxBV8Mix_AyQm_s9GHAULE1uGtnCF4756jJ0ZOEV7c74fo28n7y-1ZcfHp9HzbXRS6LFkqTGUaBY0SZcON0gqYAEUEN5WQolJNrSXVQrKBG1bTltWEtkNJm5q1ptaK8UP0Zp93F_zNkmfQzzZqmCbpwC-xZ7wVTVWWVZXR13-h134JuYNMlY3IH5JH-0CNcoLeOuNTkHpN2nc1ZS3noikzdfwPKq8B5jxOB8bm-z8C2D5ABx9jANPvgp1luOsp6VdN9HtN9GS1VRP9Wsur-4oXNcPwO-SXCDLA90DMT26E8NDSf9L-BNcTwdc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2486620350</pqid></control><display><type>article</type><title>Stool Antigen Testing, a Reliable Noninvasive Method of Assessment of Helicobacter pylori Infection Among Patients with Gastro-duodenal Disorders in Cameroon</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kouitcheu Mabeku, Laure Brigitte ; Bello Epesse, Mohamadou ; Fotsing, Stephane ; Kamgang, Roland ; Tchidjo, Magloire</creator><creatorcontrib>Kouitcheu Mabeku, Laure Brigitte ; Bello Epesse, Mohamadou ; Fotsing, Stephane ; Kamgang, Roland ; Tchidjo, Magloire</creatorcontrib><description>Background
Several techniques such as invasive and noninvasive are used for the diagnosis of
H. pylori
infection.
Aim
The aim of this study was to compare the results of rapid urease test, stool antigen test and serology in diagnosing
H. pylori
infection in Cameroon.
Methods
Hundred patients (66 women and 34 men) were enrolled. Each patient gave a written consent. The study was approved by the local Ethical Committee of Medical Sciences and the institutional review board. From each patient, blood, stool and gastric biopsies samples were collected for
H. pylori
detection using three methods: stool antigen test, serology and rapid urease test (RUT), taken as gold standard. Statistical analysis was performed using Graph pad Prism 7.
Results
Helicobacter pylori
infection was detected in 43%, 45% and 73% of patients based on the RUT, stool antigen test and serology, respectively. The difference was statistically significant between serology and RUT (
P
= 0.0026), but not between stool antigens test and RUT (
P
= 0.288). Taken RUT as gold standard, the sensitivity, specificity, positive and negative predictive values of stool antigens test and serology were 65.11, 70.17, 62.22 and 72.72%; 88.37, 40.35, 55.77 and 82.14%, respectively. The accuracy of stool antigen test and serology was 68 and 61%, respectively.
Conclusions
Our finding showed that stool antigen test can be used as a noninvasive method of assessment of
H. pylori
infection in our setting. Serological test can be used in screening; however, further diagnostic tests need to be carried out to confirm seropositive cases.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-020-06219-0</identifier><identifier>PMID: 32350723</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analysis ; Antigens ; Antigens, Bacterial - isolation & purification ; Bacterial infections ; Biochemistry ; Cameroon - epidemiology ; Cross-Sectional Studies ; Diagnosis ; Duodenum - microbiology ; Enzymes ; Feces - microbiology ; Female ; Gastroenterology ; Gastrointestinal diseases ; Gastrointestinal Diseases - diagnosis ; Gastrointestinal Diseases - epidemiology ; Gastrointestinal Diseases - microbiology ; Health aspects ; Helicobacter infections ; Helicobacter Infections - diagnosis ; Helicobacter Infections - epidemiology ; Helicobacter pylori ; Helicobacter pylori - isolation & purification ; Hepatology ; Humans ; Hydrolases ; Infection ; Male ; Medical diagnosis ; Medical tests ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Original Article ; Patients ; Serology ; Transplant Surgery ; Young Adult</subject><ispartof>Digestive diseases and sciences, 2021-02, Vol.66 (2), p.511-520</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-f5f8be8b6483fbcbe26eb063f56a65b87ca1c6a2d3f271927019d418729f7cb23</citedby><cites>FETCH-LOGICAL-c442t-f5f8be8b6483fbcbe26eb063f56a65b87ca1c6a2d3f271927019d418729f7cb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-020-06219-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-020-06219-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32350723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kouitcheu Mabeku, Laure Brigitte</creatorcontrib><creatorcontrib>Bello Epesse, Mohamadou</creatorcontrib><creatorcontrib>Fotsing, Stephane</creatorcontrib><creatorcontrib>Kamgang, Roland</creatorcontrib><creatorcontrib>Tchidjo, Magloire</creatorcontrib><title>Stool Antigen Testing, a Reliable Noninvasive Method of Assessment of Helicobacter pylori Infection Among Patients with Gastro-duodenal Disorders in Cameroon</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background
Several techniques such as invasive and noninvasive are used for the diagnosis of
H. pylori
infection.
Aim
The aim of this study was to compare the results of rapid urease test, stool antigen test and serology in diagnosing
H. pylori
infection in Cameroon.
Methods
Hundred patients (66 women and 34 men) were enrolled. Each patient gave a written consent. The study was approved by the local Ethical Committee of Medical Sciences and the institutional review board. From each patient, blood, stool and gastric biopsies samples were collected for
H. pylori
detection using three methods: stool antigen test, serology and rapid urease test (RUT), taken as gold standard. Statistical analysis was performed using Graph pad Prism 7.
Results
Helicobacter pylori
infection was detected in 43%, 45% and 73% of patients based on the RUT, stool antigen test and serology, respectively. The difference was statistically significant between serology and RUT (
P
= 0.0026), but not between stool antigens test and RUT (
P
= 0.288). Taken RUT as gold standard, the sensitivity, specificity, positive and negative predictive values of stool antigens test and serology were 65.11, 70.17, 62.22 and 72.72%; 88.37, 40.35, 55.77 and 82.14%, respectively. The accuracy of stool antigen test and serology was 68 and 61%, respectively.
Conclusions
Our finding showed that stool antigen test can be used as a noninvasive method of assessment of
H. pylori
infection in our setting. Serological test can be used in screening; however, further diagnostic tests need to be carried out to confirm seropositive cases.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Antigens</subject><subject>Antigens, Bacterial - isolation & purification</subject><subject>Bacterial infections</subject><subject>Biochemistry</subject><subject>Cameroon - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Diagnosis</subject><subject>Duodenum - microbiology</subject><subject>Enzymes</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gastrointestinal diseases</subject><subject>Gastrointestinal Diseases - diagnosis</subject><subject>Gastrointestinal Diseases - epidemiology</subject><subject>Gastrointestinal Diseases - microbiology</subject><subject>Health aspects</subject><subject>Helicobacter infections</subject><subject>Helicobacter Infections - diagnosis</subject><subject>Helicobacter Infections - epidemiology</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - isolation & purification</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Hydrolases</subject><subject>Infection</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical tests</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Patients</subject><subject>Serology</subject><subject>Transplant Surgery</subject><subject>Young Adult</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kstu1TAQhi0EoofCC7BAltiwaIoviZMsowO9SOUiKOvIdsapq8Q-tZ2iPgzviqNTqEAIWSOP7W9GM-MfoZeUHFNC6reREsFIQVYTjLYFeYQ2tKp5wSrRPEYbQkX2KRUH6FmM14SQtqbiKTrgjFekZnyDfnxN3k-4c8mO4PAlxGTdeIQl_gKTlWoC_NE7625ltLeAP0C68gP2BncxQowzuLSezjKsvZI6QcC7u8kHi8-dAZ2sd7ibvRvxZ5lsxiP-btMVPpUxBV8Mix_AyQm_s9GHAULE1uGtnCF4756jJ0ZOEV7c74fo28n7y-1ZcfHp9HzbXRS6LFkqTGUaBY0SZcON0gqYAEUEN5WQolJNrSXVQrKBG1bTltWEtkNJm5q1ptaK8UP0Zp93F_zNkmfQzzZqmCbpwC-xZ7wVTVWWVZXR13-h134JuYNMlY3IH5JH-0CNcoLeOuNTkHpN2nc1ZS3noikzdfwPKq8B5jxOB8bm-z8C2D5ABx9jANPvgp1luOsp6VdN9HtN9GS1VRP9Wsur-4oXNcPwO-SXCDLA90DMT26E8NDSf9L-BNcTwdc</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Kouitcheu Mabeku, Laure Brigitte</creator><creator>Bello Epesse, Mohamadou</creator><creator>Fotsing, Stephane</creator><creator>Kamgang, Roland</creator><creator>Tchidjo, Magloire</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20210201</creationdate><title>Stool Antigen Testing, a Reliable Noninvasive Method of Assessment of Helicobacter pylori Infection Among Patients with Gastro-duodenal Disorders in Cameroon</title><author>Kouitcheu Mabeku, Laure Brigitte ; Bello Epesse, Mohamadou ; Fotsing, Stephane ; Kamgang, Roland ; Tchidjo, Magloire</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-f5f8be8b6483fbcbe26eb063f56a65b87ca1c6a2d3f271927019d418729f7cb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Antigens</topic><topic>Antigens, Bacterial - isolation & purification</topic><topic>Bacterial infections</topic><topic>Biochemistry</topic><topic>Cameroon - epidemiology</topic><topic>Cross-Sectional Studies</topic><topic>Diagnosis</topic><topic>Duodenum - microbiology</topic><topic>Enzymes</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Gastrointestinal diseases</topic><topic>Gastrointestinal Diseases - diagnosis</topic><topic>Gastrointestinal Diseases - epidemiology</topic><topic>Gastrointestinal Diseases - microbiology</topic><topic>Health aspects</topic><topic>Helicobacter infections</topic><topic>Helicobacter Infections - diagnosis</topic><topic>Helicobacter Infections - epidemiology</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - isolation & purification</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Hydrolases</topic><topic>Infection</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical tests</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Patients</topic><topic>Serology</topic><topic>Transplant Surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kouitcheu Mabeku, Laure Brigitte</creatorcontrib><creatorcontrib>Bello Epesse, Mohamadou</creatorcontrib><creatorcontrib>Fotsing, Stephane</creatorcontrib><creatorcontrib>Kamgang, Roland</creatorcontrib><creatorcontrib>Tchidjo, Magloire</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kouitcheu Mabeku, Laure Brigitte</au><au>Bello Epesse, Mohamadou</au><au>Fotsing, Stephane</au><au>Kamgang, Roland</au><au>Tchidjo, Magloire</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stool Antigen Testing, a Reliable Noninvasive Method of Assessment of Helicobacter pylori Infection Among Patients with Gastro-duodenal Disorders in Cameroon</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>66</volume><issue>2</issue><spage>511</spage><epage>520</epage><pages>511-520</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><abstract>Background
Several techniques such as invasive and noninvasive are used for the diagnosis of
H. pylori
infection.
Aim
The aim of this study was to compare the results of rapid urease test, stool antigen test and serology in diagnosing
H. pylori
infection in Cameroon.
Methods
Hundred patients (66 women and 34 men) were enrolled. Each patient gave a written consent. The study was approved by the local Ethical Committee of Medical Sciences and the institutional review board. From each patient, blood, stool and gastric biopsies samples were collected for
H. pylori
detection using three methods: stool antigen test, serology and rapid urease test (RUT), taken as gold standard. Statistical analysis was performed using Graph pad Prism 7.
Results
Helicobacter pylori
infection was detected in 43%, 45% and 73% of patients based on the RUT, stool antigen test and serology, respectively. The difference was statistically significant between serology and RUT (
P
= 0.0026), but not between stool antigens test and RUT (
P
= 0.288). Taken RUT as gold standard, the sensitivity, specificity, positive and negative predictive values of stool antigens test and serology were 65.11, 70.17, 62.22 and 72.72%; 88.37, 40.35, 55.77 and 82.14%, respectively. The accuracy of stool antigen test and serology was 68 and 61%, respectively.
Conclusions
Our finding showed that stool antigen test can be used as a noninvasive method of assessment of
H. pylori
infection in our setting. Serological test can be used in screening; however, further diagnostic tests need to be carried out to confirm seropositive cases.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32350723</pmid><doi>10.1007/s10620-020-06219-0</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Digestive diseases and sciences, 2021-02, Vol.66 (2), p.511-520 |
| issn | 0163-2116 1573-2568 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Adult Aged Aged, 80 and over Analysis Antigens Antigens, Bacterial - isolation & purification Bacterial infections Biochemistry Cameroon - epidemiology Cross-Sectional Studies Diagnosis Duodenum - microbiology Enzymes Feces - microbiology Female Gastroenterology Gastrointestinal diseases Gastrointestinal Diseases - diagnosis Gastrointestinal Diseases - epidemiology Gastrointestinal Diseases - microbiology Health aspects Helicobacter infections Helicobacter Infections - diagnosis Helicobacter Infections - epidemiology Helicobacter pylori Helicobacter pylori - isolation & purification Hepatology Humans Hydrolases Infection Male Medical diagnosis Medical tests Medicine Medicine & Public Health Middle Aged Oncology Original Article Patients Serology Transplant Surgery Young Adult |
| title | Stool Antigen Testing, a Reliable Noninvasive Method of Assessment of Helicobacter pylori Infection Among Patients with Gastro-duodenal Disorders in Cameroon |
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