Uncovering molecular targets for regenerative therapy in degenerative disc disease: do small leucine-rich proteoglycans hold the key?

Small leucine-rich proteoglycans (SLRPs) play an essential role in extracellular matrix (ECM) organization and function. Recently, dysregulation of SLRPs has been implicated in degenerative disc disease (DDD). An in-depth analysis using high-throughput proteomic sequencing might provide valuable inf...

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Veröffentlicht in:	The spine journal 2021-01, Vol.21 (1), p.5-19
Hauptverfasser:	Rajasekaran, Shanmuganathan, Soundararajan, Dilip Chand Raja, Tangavel, Chitraa, Nayagam, Sharon Miracle, K S, Sri Vijayanand, R, Sunmathi, Matchado, Monica Steffi, Muthurajan, Raveendran, Shetty, Ajoy Prasad, Kanna, Rishi Mugesh, K, Dharmalingam
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biglycan Chondroitin Sulfate Proteoglycans Chromatography, Liquid Extracellular Matrix Proteins Fetus Humans Intervertebral Disc Degeneration Intervertebral disc regeneration Lumican Proteoglycans Proteomics Small leucine-rich proteins Small Leucine-Rich Proteoglycans Tandem Mass Spectrometry
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