FAP-specific PET signaling shows a moderately positive correlation with relative CBV and no correlation with ADC in 13 IDH wildtype glioblastomas
•FAP-specific PET signaling in glioblastomas shows a moderately positive correlation with rCBV.•FAP-specific PET signaling in glioblastomas shows no correlation with ADC.•FAP-specific PET/CT is an independent novel imaging modality for glioblastomas. Targeting Fibroblast Activation Protein (FAP) is...
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| Veröffentlicht in: | European journal of radiology 2020-06, Vol.127, p.109021-109021, Article 109021 |
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| container_title | European journal of radiology |
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| creator | Röhrich, Manuel Floca, Ralf Loi, Lisa Adeberg, Sebastian Windisch, Paul Giesel, Frederik L. Kratochwil, Clemens Flechsig, Paul Rathke, Hendrik Lindner, Thomas Loktev, Anastasia Schlemmer, Heinz Peter Haberkorn, Uwe Paech, Daniel |
| description | •FAP-specific PET signaling in glioblastomas shows a moderately positive correlation with rCBV.•FAP-specific PET signaling in glioblastomas shows no correlation with ADC.•FAP-specific PET/CT is an independent novel imaging modality for glioblastomas.
Targeting Fibroblast Activation Protein (FAP) is a new approach for glioblastoma imaging. In a recent pilot study glioblastomas showed elevated tracer uptake with high intratumoral heterogeneity in projection on the corresponding T2w/FLAIR and contrast enhanced MRI lesions. In this study, we correlated FAP-specific signaling with apparent diffusion coefficient (ADC) and relative cerebral blood volume (rCBV) signals in MRI to further characterize the significance of FAP uptake.
Clinical PET/CT scans of 13 glioblastoma patients were performed post i. v. administration of 68Ga-labelled-FAP-specific tracer molecules. PET- and corresponding MRI-scans were co-registrated. 3d volumetric segmentations were performed of T2w/FLAIR lesions and contrast enhancing lesions within co-registrated MRI slides. Signal intensity values of FAP-specific PET signaling, ADC and rCBV were analyzed for their pixel wise correlation in each patient. Pooled estimates of the correlation coefficients were calculated by using the Fisher z-transformation.
FAP-specific PET signals showed a moderately positive correlation with rCBV values which is more pronounced within the T2w/FLAIR lesion (pooled correlation 0,229) than in the contrast enhancing tumor region (pooled correlation 0.09). FAP-specific PET signals showed no correlation with ADC values.
The moderately positive correlation of FAP-specific signals with rCBV values in MRI indicates that FAP-signaling is not independent from perfusion, but also does not only reflect intratumoral perfusion differences. The missing correlation of FAP-specific signals with ADC indicates that FAP-specific imaging does not reflect cell density, but the spot-like expression of FAP in glioblastomas. The clinical value of FAP-specific imaging needs further investigation. |
| doi_str_mv | 10.1016/j.ejrad.2020.109021 |
| format | Article |
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Targeting Fibroblast Activation Protein (FAP) is a new approach for glioblastoma imaging. In a recent pilot study glioblastomas showed elevated tracer uptake with high intratumoral heterogeneity in projection on the corresponding T2w/FLAIR and contrast enhanced MRI lesions. In this study, we correlated FAP-specific signaling with apparent diffusion coefficient (ADC) and relative cerebral blood volume (rCBV) signals in MRI to further characterize the significance of FAP uptake.
Clinical PET/CT scans of 13 glioblastoma patients were performed post i. v. administration of 68Ga-labelled-FAP-specific tracer molecules. PET- and corresponding MRI-scans were co-registrated. 3d volumetric segmentations were performed of T2w/FLAIR lesions and contrast enhancing lesions within co-registrated MRI slides. Signal intensity values of FAP-specific PET signaling, ADC and rCBV were analyzed for their pixel wise correlation in each patient. Pooled estimates of the correlation coefficients were calculated by using the Fisher z-transformation.
FAP-specific PET signals showed a moderately positive correlation with rCBV values which is more pronounced within the T2w/FLAIR lesion (pooled correlation 0,229) than in the contrast enhancing tumor region (pooled correlation 0.09). FAP-specific PET signals showed no correlation with ADC values.
The moderately positive correlation of FAP-specific signals with rCBV values in MRI indicates that FAP-signaling is not independent from perfusion, but also does not only reflect intratumoral perfusion differences. The missing correlation of FAP-specific signals with ADC indicates that FAP-specific imaging does not reflect cell density, but the spot-like expression of FAP in glioblastomas. The clinical value of FAP-specific imaging needs further investigation.</description><identifier>ISSN: 0720-048X</identifier><identifier>EISSN: 1872-7727</identifier><identifier>DOI: 10.1016/j.ejrad.2020.109021</identifier><identifier>PMID: 32344293</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>ADC ; Adult ; Aged ; Aged, 80 and over ; Brain Neoplasms - diagnostic imaging ; Brain Neoplasms - genetics ; Brain Neoplasms - pathology ; CBV ; Cerebral Blood Volume - physiology ; FAP ; Female ; Fibroblast activation protein ; Gallium Radioisotopes ; Gelatinases - genetics ; Glioblastoma ; Glioblastoma - diagnostic imaging ; Glioblastoma - genetics ; Glioblastoma - pathology ; Humans ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging - methods ; Male ; Membrane Proteins - genetics ; Middle Aged ; PET ; Pilot Projects ; Positron Emission Tomography Computed Tomography - methods ; Serine Endopeptidases - genetics ; Young Adult</subject><ispartof>European journal of radiology, 2020-06, Vol.127, p.109021-109021, Article 109021</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-4b8262007328d601575053f788fa33f6961d6b5a69c6ad4f6907172aa87784193</citedby><cites>FETCH-LOGICAL-c359t-4b8262007328d601575053f788fa33f6961d6b5a69c6ad4f6907172aa87784193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0720048X20302102$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32344293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Röhrich, Manuel</creatorcontrib><creatorcontrib>Floca, Ralf</creatorcontrib><creatorcontrib>Loi, Lisa</creatorcontrib><creatorcontrib>Adeberg, Sebastian</creatorcontrib><creatorcontrib>Windisch, Paul</creatorcontrib><creatorcontrib>Giesel, Frederik L.</creatorcontrib><creatorcontrib>Kratochwil, Clemens</creatorcontrib><creatorcontrib>Flechsig, Paul</creatorcontrib><creatorcontrib>Rathke, Hendrik</creatorcontrib><creatorcontrib>Lindner, Thomas</creatorcontrib><creatorcontrib>Loktev, Anastasia</creatorcontrib><creatorcontrib>Schlemmer, Heinz Peter</creatorcontrib><creatorcontrib>Haberkorn, Uwe</creatorcontrib><creatorcontrib>Paech, Daniel</creatorcontrib><title>FAP-specific PET signaling shows a moderately positive correlation with relative CBV and no correlation with ADC in 13 IDH wildtype glioblastomas</title><title>European journal of radiology</title><addtitle>Eur J Radiol</addtitle><description>•FAP-specific PET signaling in glioblastomas shows a moderately positive correlation with rCBV.•FAP-specific PET signaling in glioblastomas shows no correlation with ADC.•FAP-specific PET/CT is an independent novel imaging modality for glioblastomas.
Targeting Fibroblast Activation Protein (FAP) is a new approach for glioblastoma imaging. In a recent pilot study glioblastomas showed elevated tracer uptake with high intratumoral heterogeneity in projection on the corresponding T2w/FLAIR and contrast enhanced MRI lesions. In this study, we correlated FAP-specific signaling with apparent diffusion coefficient (ADC) and relative cerebral blood volume (rCBV) signals in MRI to further characterize the significance of FAP uptake.
Clinical PET/CT scans of 13 glioblastoma patients were performed post i. v. administration of 68Ga-labelled-FAP-specific tracer molecules. PET- and corresponding MRI-scans were co-registrated. 3d volumetric segmentations were performed of T2w/FLAIR lesions and contrast enhancing lesions within co-registrated MRI slides. Signal intensity values of FAP-specific PET signaling, ADC and rCBV were analyzed for their pixel wise correlation in each patient. Pooled estimates of the correlation coefficients were calculated by using the Fisher z-transformation.
FAP-specific PET signals showed a moderately positive correlation with rCBV values which is more pronounced within the T2w/FLAIR lesion (pooled correlation 0,229) than in the contrast enhancing tumor region (pooled correlation 0.09). FAP-specific PET signals showed no correlation with ADC values.
The moderately positive correlation of FAP-specific signals with rCBV values in MRI indicates that FAP-signaling is not independent from perfusion, but also does not only reflect intratumoral perfusion differences. The missing correlation of FAP-specific signals with ADC indicates that FAP-specific imaging does not reflect cell density, but the spot-like expression of FAP in glioblastomas. The clinical value of FAP-specific imaging needs further investigation.</description><subject>ADC</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - pathology</subject><subject>CBV</subject><subject>Cerebral Blood Volume - physiology</subject><subject>FAP</subject><subject>Female</subject><subject>Fibroblast activation protein</subject><subject>Gallium Radioisotopes</subject><subject>Gelatinases - genetics</subject><subject>Glioblastoma</subject><subject>Glioblastoma - diagnostic imaging</subject><subject>Glioblastoma - genetics</subject><subject>Glioblastoma - pathology</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Membrane Proteins - genetics</subject><subject>Middle Aged</subject><subject>PET</subject><subject>Pilot Projects</subject><subject>Positron Emission Tomography Computed Tomography - methods</subject><subject>Serine Endopeptidases - genetics</subject><subject>Young Adult</subject><issn>0720-048X</issn><issn>1872-7727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v2zAMhoVhxZp2-wUDBh13caoPW7IPO6TpJ1BgPXTDboIi0akC2XIlpUV-Rv9xnbrbpcBOBF8-JEG-CH2lZE4JFSebOWyitnNG2F5pCKMf0IzWkhVSMvkRzYhkpCBl_ecQHaW0IYRUZcM-oUPOeFmyhs_Q88XitkgDGNc6g2_P73By6157169xug9PCWvcBQtRZ_A7PITksnsEbEKM4HV2ocdPLt_jKRsry9PfWPcW9-E9tDhbYtdjyvH12dUoeZt3A-C1d2Hldcqh0-kzOmi1T_DlLR6jXxfnd8ur4ubn5fVycVMYXjW5KFc1E4wQyVltBaGVrEjFW1nXrea8FY2gVqwqLRojtC1HgUgqmda1lHVJG36Mvk9zhxgetpCy6lwy4L3uIWyTYrwRfPyg4CPKJ9TEkFKEVg3RdTruFCVq74XaqFcv1N4LNXkxdn17W7BddWD_9fx9_gj8mAAYz3x0EFUyDnoD1kUwWdng_rvgBZykmp8</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Röhrich, Manuel</creator><creator>Floca, Ralf</creator><creator>Loi, Lisa</creator><creator>Adeberg, Sebastian</creator><creator>Windisch, Paul</creator><creator>Giesel, Frederik L.</creator><creator>Kratochwil, Clemens</creator><creator>Flechsig, Paul</creator><creator>Rathke, Hendrik</creator><creator>Lindner, Thomas</creator><creator>Loktev, Anastasia</creator><creator>Schlemmer, Heinz Peter</creator><creator>Haberkorn, Uwe</creator><creator>Paech, Daniel</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202006</creationdate><title>FAP-specific PET signaling shows a moderately positive correlation with relative CBV and no correlation with ADC in 13 IDH wildtype glioblastomas</title><author>Röhrich, Manuel ; Floca, Ralf ; Loi, Lisa ; Adeberg, Sebastian ; Windisch, Paul ; Giesel, Frederik L. ; Kratochwil, Clemens ; Flechsig, Paul ; Rathke, Hendrik ; Lindner, Thomas ; Loktev, Anastasia ; Schlemmer, Heinz Peter ; Haberkorn, Uwe ; Paech, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-4b8262007328d601575053f788fa33f6961d6b5a69c6ad4f6907172aa87784193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>ADC</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Brain Neoplasms - diagnostic imaging</topic><topic>Brain Neoplasms - genetics</topic><topic>Brain Neoplasms - pathology</topic><topic>CBV</topic><topic>Cerebral Blood Volume - physiology</topic><topic>FAP</topic><topic>Female</topic><topic>Fibroblast activation protein</topic><topic>Gallium Radioisotopes</topic><topic>Gelatinases - genetics</topic><topic>Glioblastoma</topic><topic>Glioblastoma - diagnostic imaging</topic><topic>Glioblastoma - genetics</topic><topic>Glioblastoma - pathology</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Membrane Proteins - genetics</topic><topic>Middle Aged</topic><topic>PET</topic><topic>Pilot Projects</topic><topic>Positron Emission Tomography Computed Tomography - methods</topic><topic>Serine Endopeptidases - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Röhrich, Manuel</creatorcontrib><creatorcontrib>Floca, Ralf</creatorcontrib><creatorcontrib>Loi, Lisa</creatorcontrib><creatorcontrib>Adeberg, Sebastian</creatorcontrib><creatorcontrib>Windisch, Paul</creatorcontrib><creatorcontrib>Giesel, Frederik L.</creatorcontrib><creatorcontrib>Kratochwil, Clemens</creatorcontrib><creatorcontrib>Flechsig, Paul</creatorcontrib><creatorcontrib>Rathke, Hendrik</creatorcontrib><creatorcontrib>Lindner, Thomas</creatorcontrib><creatorcontrib>Loktev, Anastasia</creatorcontrib><creatorcontrib>Schlemmer, Heinz Peter</creatorcontrib><creatorcontrib>Haberkorn, Uwe</creatorcontrib><creatorcontrib>Paech, Daniel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Röhrich, Manuel</au><au>Floca, Ralf</au><au>Loi, Lisa</au><au>Adeberg, Sebastian</au><au>Windisch, Paul</au><au>Giesel, Frederik L.</au><au>Kratochwil, Clemens</au><au>Flechsig, Paul</au><au>Rathke, Hendrik</au><au>Lindner, Thomas</au><au>Loktev, Anastasia</au><au>Schlemmer, Heinz Peter</au><au>Haberkorn, Uwe</au><au>Paech, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FAP-specific PET signaling shows a moderately positive correlation with relative CBV and no correlation with ADC in 13 IDH wildtype glioblastomas</atitle><jtitle>European journal of radiology</jtitle><addtitle>Eur J Radiol</addtitle><date>2020-06</date><risdate>2020</risdate><volume>127</volume><spage>109021</spage><epage>109021</epage><pages>109021-109021</pages><artnum>109021</artnum><issn>0720-048X</issn><eissn>1872-7727</eissn><abstract>•FAP-specific PET signaling in glioblastomas shows a moderately positive correlation with rCBV.•FAP-specific PET signaling in glioblastomas shows no correlation with ADC.•FAP-specific PET/CT is an independent novel imaging modality for glioblastomas.
Targeting Fibroblast Activation Protein (FAP) is a new approach for glioblastoma imaging. In a recent pilot study glioblastomas showed elevated tracer uptake with high intratumoral heterogeneity in projection on the corresponding T2w/FLAIR and contrast enhanced MRI lesions. In this study, we correlated FAP-specific signaling with apparent diffusion coefficient (ADC) and relative cerebral blood volume (rCBV) signals in MRI to further characterize the significance of FAP uptake.
Clinical PET/CT scans of 13 glioblastoma patients were performed post i. v. administration of 68Ga-labelled-FAP-specific tracer molecules. PET- and corresponding MRI-scans were co-registrated. 3d volumetric segmentations were performed of T2w/FLAIR lesions and contrast enhancing lesions within co-registrated MRI slides. Signal intensity values of FAP-specific PET signaling, ADC and rCBV were analyzed for their pixel wise correlation in each patient. Pooled estimates of the correlation coefficients were calculated by using the Fisher z-transformation.
FAP-specific PET signals showed a moderately positive correlation with rCBV values which is more pronounced within the T2w/FLAIR lesion (pooled correlation 0,229) than in the contrast enhancing tumor region (pooled correlation 0.09). FAP-specific PET signals showed no correlation with ADC values.
The moderately positive correlation of FAP-specific signals with rCBV values in MRI indicates that FAP-signaling is not independent from perfusion, but also does not only reflect intratumoral perfusion differences. The missing correlation of FAP-specific signals with ADC indicates that FAP-specific imaging does not reflect cell density, but the spot-like expression of FAP in glioblastomas. The clinical value of FAP-specific imaging needs further investigation.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>32344293</pmid><doi>10.1016/j.ejrad.2020.109021</doi><tpages>1</tpages></addata></record> |
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| subjects | ADC Adult Aged Aged, 80 and over Brain Neoplasms - diagnostic imaging Brain Neoplasms - genetics Brain Neoplasms - pathology CBV Cerebral Blood Volume - physiology FAP Female Fibroblast activation protein Gallium Radioisotopes Gelatinases - genetics Glioblastoma Glioblastoma - diagnostic imaging Glioblastoma - genetics Glioblastoma - pathology Humans Imaging, Three-Dimensional Magnetic Resonance Imaging - methods Male Membrane Proteins - genetics Middle Aged PET Pilot Projects Positron Emission Tomography Computed Tomography - methods Serine Endopeptidases - genetics Young Adult |
| title | FAP-specific PET signaling shows a moderately positive correlation with relative CBV and no correlation with ADC in 13 IDH wildtype glioblastomas |
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