Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study
To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD. Asymptomatic patients (8-45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (...
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| Veröffentlicht in: | Diabetes care 2020-07, Vol.43 (7), p.1553-1556 |
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| creator | Mahmud, Farid H Clarke, Antoine B M Joachim, Kariym C Assor, Esther McDonald, Charlotte Saibil, Fred Lochnan, Heather A Punthakee, Zubin Parikh, Amish Advani, Andrew Shah, Baiju R Perkins, Bruce A Zuijdwijk, Caroline S Mack, David R Koltin, Dror De Melo, Emilia N Hsieh, Eugene Mukerji, Geetha Gilbert, Jeremy Bax, Kevin Lawson, Margaret L Cino, Maria Beaton, Melanie D Saloojee, Navaaz A Lou, Olivia Gallego, Patricia H Bercik, Premysl Houlden, Robyn L Aronson, Ronnie Kirsch, Susan E Paterson, William G Marcon, Margaret A |
| description | To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD.
Asymptomatic patients (8-45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA
and continuous glucose monitoring over 12 months.
Adults had higher CD-seropositivity rates than children (6.8% [95% CI 4.9-8.2%,
= 1,298] vs. 4.7% [95% CI 3.4-5.9%,
= 1,089],
= 0.035) with lower rates of prior CD screening (6.9% vs. 44.2%,
< 0.0001). Fifty-one participants were randomized to a GFD (
= 27) or GCD (
= 24). No HbA
differences were seen between the groups (+0.14%, 1.5 mmol/mol; 95% CI -0.79 to 1.08;
= 0.76), although greater postprandial glucose increases (4-h +1.5 mmol/L; 95% CI 0.4-2.7;
= 0.014) emerged with a GFD.
CD is frequently observed in asymptomatic patients with type 1 diabetes, and clinical vigilance is warranted with initiation of a GFD. |
| doi_str_mv | 10.2337/dc19-1944 |
| format | Article |
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Asymptomatic patients (8-45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA
and continuous glucose monitoring over 12 months.
Adults had higher CD-seropositivity rates than children (6.8% [95% CI 4.9-8.2%,
= 1,298] vs. 4.7% [95% CI 3.4-5.9%,
= 1,089],
= 0.035) with lower rates of prior CD screening (6.9% vs. 44.2%,
< 0.0001). Fifty-one participants were randomized to a GFD (
= 27) or GCD (
= 24). No HbA
differences were seen between the groups (+0.14%, 1.5 mmol/mol; 95% CI -0.79 to 1.08;
= 0.76), although greater postprandial glucose increases (4-h +1.5 mmol/L; 95% CI 0.4-2.7;
= 0.014) emerged with a GFD.
CD is frequently observed in asymptomatic patients with type 1 diabetes, and clinical vigilance is warranted with initiation of a GFD.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc19-1944</identifier><identifier>PMID: 32345653</identifier><language>eng</language><publisher>United States: American Diabetes Association</publisher><subject>Adolescent ; Adult ; Adults ; Asymptomatic Diseases ; Autoantibodies - analysis ; Autoantibodies - blood ; Autoimmune diseases ; Biopsy ; Blood Glucose - analysis ; Blood Glucose - metabolism ; Blood Glucose Self-Monitoring ; Canada ; Celiac disease ; Celiac Disease - blood ; Celiac Disease - complications ; Celiac Disease - diagnosis ; Celiac Disease - diet therapy ; Child ; Children ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (insulin dependent) ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - diagnosis ; Diabetes Mellitus, Type 1 - diet therapy ; Diet ; Diet, Gluten-Free ; Female ; Glucose ; Glucose monitoring ; Gluten ; Humans ; Male ; Mass Screening ; Middle Aged ; Patients ; Postprandial Period ; Randomization ; Research design ; Serologic Tests ; Treatment Outcome ; Vigilance ; Young Adult</subject><ispartof>Diabetes care, 2020-07, Vol.43 (7), p.1553-1556</ispartof><rights>2020 by the American Diabetes Association.</rights><rights>Copyright American Diabetes Association Jul 1, 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-6600c71f05004cba9e01abc286e4cc2f29a130370c2627153634ec7de880c96c3</citedby><cites>FETCH-LOGICAL-c348t-6600c71f05004cba9e01abc286e4cc2f29a130370c2627153634ec7de880c96c3</cites><orcidid>0000-0002-8976-2321 ; 0000-0002-2370-9552 ; 0000-0003-0497-645X ; 0000-0002-3557-3584 ; 0000-0002-3001-0213 ; 0000-0003-3598-3628 ; 0000-0002-5885-0046</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32345653$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahmud, Farid H</creatorcontrib><creatorcontrib>Clarke, Antoine B M</creatorcontrib><creatorcontrib>Joachim, Kariym C</creatorcontrib><creatorcontrib>Assor, Esther</creatorcontrib><creatorcontrib>McDonald, Charlotte</creatorcontrib><creatorcontrib>Saibil, Fred</creatorcontrib><creatorcontrib>Lochnan, Heather A</creatorcontrib><creatorcontrib>Punthakee, Zubin</creatorcontrib><creatorcontrib>Parikh, Amish</creatorcontrib><creatorcontrib>Advani, Andrew</creatorcontrib><creatorcontrib>Shah, Baiju R</creatorcontrib><creatorcontrib>Perkins, Bruce A</creatorcontrib><creatorcontrib>Zuijdwijk, Caroline S</creatorcontrib><creatorcontrib>Mack, David R</creatorcontrib><creatorcontrib>Koltin, Dror</creatorcontrib><creatorcontrib>De Melo, Emilia N</creatorcontrib><creatorcontrib>Hsieh, Eugene</creatorcontrib><creatorcontrib>Mukerji, Geetha</creatorcontrib><creatorcontrib>Gilbert, Jeremy</creatorcontrib><creatorcontrib>Bax, Kevin</creatorcontrib><creatorcontrib>Lawson, Margaret L</creatorcontrib><creatorcontrib>Cino, Maria</creatorcontrib><creatorcontrib>Beaton, Melanie D</creatorcontrib><creatorcontrib>Saloojee, Navaaz A</creatorcontrib><creatorcontrib>Lou, Olivia</creatorcontrib><creatorcontrib>Gallego, Patricia H</creatorcontrib><creatorcontrib>Bercik, Premysl</creatorcontrib><creatorcontrib>Houlden, Robyn L</creatorcontrib><creatorcontrib>Aronson, Ronnie</creatorcontrib><creatorcontrib>Kirsch, Susan E</creatorcontrib><creatorcontrib>Paterson, William G</creatorcontrib><creatorcontrib>Marcon, Margaret A</creatorcontrib><title>Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD.
Asymptomatic patients (8-45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA
and continuous glucose monitoring over 12 months.
Adults had higher CD-seropositivity rates than children (6.8% [95% CI 4.9-8.2%,
= 1,298] vs. 4.7% [95% CI 3.4-5.9%,
= 1,089],
= 0.035) with lower rates of prior CD screening (6.9% vs. 44.2%,
< 0.0001). Fifty-one participants were randomized to a GFD (
= 27) or GCD (
= 24). No HbA
differences were seen between the groups (+0.14%, 1.5 mmol/mol; 95% CI -0.79 to 1.08;
= 0.76), although greater postprandial glucose increases (4-h +1.5 mmol/L; 95% CI 0.4-2.7;
= 0.014) emerged with a GFD.
CD is frequently observed in asymptomatic patients with type 1 diabetes, and clinical vigilance is warranted with initiation of a GFD.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Asymptomatic Diseases</subject><subject>Autoantibodies - analysis</subject><subject>Autoantibodies - blood</subject><subject>Autoimmune diseases</subject><subject>Biopsy</subject><subject>Blood Glucose - analysis</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Glucose Self-Monitoring</subject><subject>Canada</subject><subject>Celiac disease</subject><subject>Celiac Disease - blood</subject><subject>Celiac Disease - complications</subject><subject>Celiac Disease - diagnosis</subject><subject>Celiac Disease - diet therapy</subject><subject>Child</subject><subject>Children</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - diagnosis</subject><subject>Diabetes Mellitus, Type 1 - diet therapy</subject><subject>Diet</subject><subject>Diet, Gluten-Free</subject><subject>Female</subject><subject>Glucose</subject><subject>Glucose monitoring</subject><subject>Gluten</subject><subject>Humans</subject><subject>Male</subject><subject>Mass Screening</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Postprandial Period</subject><subject>Randomization</subject><subject>Research design</subject><subject>Serologic Tests</subject><subject>Treatment Outcome</subject><subject>Vigilance</subject><subject>Young Adult</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0T1PG0EQgOFVlCg4QMEfQCulIcWF_b7bdNYZAhKSC1-U8rSeG-NF92F29wpX_HXOGFKkmubRaEYvIRec_RRS5tcNcJtxq9QnMuNW6kxrVXwmM8aVzbS14oR8i_GJMaZUUXwlJ1JIpY2WM_KygoDY-_6Rur6hVUCXOuwTXY4Jhg4j9T2dN2Ob4hsot75tAvb0r09bWu13SDldeLfGhEcxj_tul4bOJQ-0xNY7mEBEF_EXrbZIy0W2uL-p6CqNzf6MfNm4NuL5-zwlf25vqvIue1j-vi_nDxlIVaTMGMYg5xumpx9g7Swy7tYgCoMKQGyEdVwymTMQRuRcSyMVQt5gUTCwBuQpuTru3YXhecSY6s5HwLZ1PQ5jrIW0RjKhmZ7o9__o0zCGfrquFoobLTiX-aR-HBWEIcaAm3oXfOfCvuasPlSpD1XqQ5XJXr5vHNcdNv_kRwb5CpUghPo</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Mahmud, Farid H</creator><creator>Clarke, Antoine B M</creator><creator>Joachim, Kariym C</creator><creator>Assor, Esther</creator><creator>McDonald, Charlotte</creator><creator>Saibil, Fred</creator><creator>Lochnan, Heather A</creator><creator>Punthakee, Zubin</creator><creator>Parikh, Amish</creator><creator>Advani, Andrew</creator><creator>Shah, Baiju R</creator><creator>Perkins, Bruce A</creator><creator>Zuijdwijk, Caroline S</creator><creator>Mack, David R</creator><creator>Koltin, Dror</creator><creator>De Melo, Emilia N</creator><creator>Hsieh, Eugene</creator><creator>Mukerji, Geetha</creator><creator>Gilbert, Jeremy</creator><creator>Bax, Kevin</creator><creator>Lawson, Margaret L</creator><creator>Cino, Maria</creator><creator>Beaton, Melanie D</creator><creator>Saloojee, Navaaz A</creator><creator>Lou, Olivia</creator><creator>Gallego, Patricia H</creator><creator>Bercik, Premysl</creator><creator>Houlden, Robyn L</creator><creator>Aronson, Ronnie</creator><creator>Kirsch, Susan E</creator><creator>Paterson, William G</creator><creator>Marcon, Margaret A</creator><general>American Diabetes Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8976-2321</orcidid><orcidid>https://orcid.org/0000-0002-2370-9552</orcidid><orcidid>https://orcid.org/0000-0003-0497-645X</orcidid><orcidid>https://orcid.org/0000-0002-3557-3584</orcidid><orcidid>https://orcid.org/0000-0002-3001-0213</orcidid><orcidid>https://orcid.org/0000-0003-3598-3628</orcidid><orcidid>https://orcid.org/0000-0002-5885-0046</orcidid></search><sort><creationdate>202007</creationdate><title>Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study</title><author>Mahmud, Farid H ; Clarke, Antoine B M ; Joachim, Kariym C ; Assor, Esther ; McDonald, Charlotte ; Saibil, Fred ; Lochnan, Heather A ; Punthakee, Zubin ; Parikh, Amish ; Advani, Andrew ; Shah, Baiju R ; Perkins, Bruce A ; Zuijdwijk, Caroline S ; Mack, David R ; Koltin, Dror ; De Melo, Emilia N ; Hsieh, Eugene ; Mukerji, Geetha ; Gilbert, Jeremy ; Bax, Kevin ; Lawson, Margaret L ; Cino, Maria ; Beaton, Melanie D ; Saloojee, Navaaz A ; Lou, Olivia ; Gallego, Patricia H ; Bercik, Premysl ; Houlden, Robyn L ; Aronson, Ronnie ; Kirsch, Susan E ; Paterson, William G ; Marcon, Margaret A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-6600c71f05004cba9e01abc286e4cc2f29a130370c2627153634ec7de880c96c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adults</topic><topic>Asymptomatic Diseases</topic><topic>Autoantibodies - 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Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahmud, Farid H</au><au>Clarke, Antoine B M</au><au>Joachim, Kariym C</au><au>Assor, Esther</au><au>McDonald, Charlotte</au><au>Saibil, Fred</au><au>Lochnan, Heather A</au><au>Punthakee, Zubin</au><au>Parikh, Amish</au><au>Advani, Andrew</au><au>Shah, Baiju R</au><au>Perkins, Bruce A</au><au>Zuijdwijk, Caroline S</au><au>Mack, David R</au><au>Koltin, Dror</au><au>De Melo, Emilia N</au><au>Hsieh, Eugene</au><au>Mukerji, Geetha</au><au>Gilbert, Jeremy</au><au>Bax, Kevin</au><au>Lawson, Margaret L</au><au>Cino, Maria</au><au>Beaton, Melanie D</au><au>Saloojee, Navaaz A</au><au>Lou, Olivia</au><au>Gallego, Patricia H</au><au>Bercik, Premysl</au><au>Houlden, Robyn L</au><au>Aronson, Ronnie</au><au>Kirsch, Susan E</au><au>Paterson, William G</au><au>Marcon, Margaret A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2020-07</date><risdate>2020</risdate><volume>43</volume><issue>7</issue><spage>1553</spage><epage>1556</epage><pages>1553-1556</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><abstract>To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD.
Asymptomatic patients (8-45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA
and continuous glucose monitoring over 12 months.
Adults had higher CD-seropositivity rates than children (6.8% [95% CI 4.9-8.2%,
= 1,298] vs. 4.7% [95% CI 3.4-5.9%,
= 1,089],
= 0.035) with lower rates of prior CD screening (6.9% vs. 44.2%,
< 0.0001). Fifty-one participants were randomized to a GFD (
= 27) or GCD (
= 24). No HbA
differences were seen between the groups (+0.14%, 1.5 mmol/mol; 95% CI -0.79 to 1.08;
= 0.76), although greater postprandial glucose increases (4-h +1.5 mmol/L; 95% CI 0.4-2.7;
= 0.014) emerged with a GFD.
CD is frequently observed in asymptomatic patients with type 1 diabetes, and clinical vigilance is warranted with initiation of a GFD.</abstract><cop>United States</cop><pub>American Diabetes Association</pub><pmid>32345653</pmid><doi>10.2337/dc19-1944</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-8976-2321</orcidid><orcidid>https://orcid.org/0000-0002-2370-9552</orcidid><orcidid>https://orcid.org/0000-0003-0497-645X</orcidid><orcidid>https://orcid.org/0000-0002-3557-3584</orcidid><orcidid>https://orcid.org/0000-0002-3001-0213</orcidid><orcidid>https://orcid.org/0000-0003-3598-3628</orcidid><orcidid>https://orcid.org/0000-0002-5885-0046</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0149-5992 |
| ispartof | Diabetes care, 2020-07, Vol.43 (7), p.1553-1556 |
| issn | 0149-5992 1935-5548 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2396302505 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Adults Asymptomatic Diseases Autoantibodies - analysis Autoantibodies - blood Autoimmune diseases Biopsy Blood Glucose - analysis Blood Glucose - metabolism Blood Glucose Self-Monitoring Canada Celiac disease Celiac Disease - blood Celiac Disease - complications Celiac Disease - diagnosis Celiac Disease - diet therapy Child Children Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - diet therapy Diet Diet, Gluten-Free Female Glucose Glucose monitoring Gluten Humans Male Mass Screening Middle Aged Patients Postprandial Period Randomization Research design Serologic Tests Treatment Outcome Vigilance Young Adult |
| title | Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T04%3A16%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Screening%20and%20Treatment%20Outcomes%20in%20Adults%20and%20Children%20With%20Type%201%20Diabetes%20and%20Asymptomatic%20Celiac%20Disease:%20The%20CD-DIET%20Study&rft.jtitle=Diabetes%20care&rft.au=Mahmud,%20Farid%20H&rft.date=2020-07&rft.volume=43&rft.issue=7&rft.spage=1553&rft.epage=1556&rft.pages=1553-1556&rft.issn=0149-5992&rft.eissn=1935-5548&rft_id=info:doi/10.2337/dc19-1944&rft_dat=%3Cproquest_cross%3E2416521137%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2416521137&rft_id=info:pmid/32345653&rfr_iscdi=true |