Comparative analysis of rhinologic outcomes in Cushing disease and non-functioning pituitary adenoma in patients submitted to endoscopic endonasal transsphenoidal surgery
Purpose Adrenocorticotropic hormone (ACTH) secreted by pituitary tumors lead to changes in nasal cavity anatomy and physiology. As a consequence of hormonal alteration, there is an abnormal soft tissue and an increased capillary fragility, inducting to a thinner mucosa that acts in the healing proce...
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| Veröffentlicht in: | European archives of oto-rhino-laryngology 2020-08, Vol.277 (8), p.2371-2374 |
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| container_title | European archives of oto-rhino-laryngology |
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| creator | Toro, Mariana D. C. Serrano, Thiago L. I. Marson, Fernando A. L. Chone, Carlos T. Dal Fabbro, Mateus Sakano, Eulália Sampaio, Marcelo H. |
| description | Purpose
Adrenocorticotropic hormone (ACTH) secreted by pituitary tumors lead to changes in nasal cavity anatomy and physiology. As a consequence of hormonal alteration, there is an abnormal soft tissue and an increased capillary fragility, inducting to a thinner mucosa that acts in the healing process. We compared post-operative nasal alterations in patients with Cushing’s disease versus patients with non-functioning macroadenomas who underwent endoscopic endonasal transsphenoidal surgery.
Methods
A retrospective study with 14 patients with Cushing’s disease who underwent initial transsphenoidal endonasal surgery for an ACTH-secreting adenoma was conducted. Forty-two patients who underwent the same surgery for non-functioning adenomas were selected as controls. The following data were collected: operative technique, endoscopic alterations in late post-operative period and post-operative nasal complaints.
Results
There were 13/14 (92.9%) females with Cushing disease versus 23/42 (54.8%) in the non-functioning adenoma group. Surgical approach was similar in both groups, with no differences in flap usage, turbinectomies or ethmoidectomies. No difference occurred concerning endoscopic alterations or nasal complaints in post-operative period.
Conclusions
Post-operative results are similar, and healing could be expected to be equal. |
| doi_str_mv | 10.1007/s00405-020-05974-0 |
| format | Article |
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Adrenocorticotropic hormone (ACTH) secreted by pituitary tumors lead to changes in nasal cavity anatomy and physiology. As a consequence of hormonal alteration, there is an abnormal soft tissue and an increased capillary fragility, inducting to a thinner mucosa that acts in the healing process. We compared post-operative nasal alterations in patients with Cushing’s disease versus patients with non-functioning macroadenomas who underwent endoscopic endonasal transsphenoidal surgery.
Methods
A retrospective study with 14 patients with Cushing’s disease who underwent initial transsphenoidal endonasal surgery for an ACTH-secreting adenoma was conducted. Forty-two patients who underwent the same surgery for non-functioning adenomas were selected as controls. The following data were collected: operative technique, endoscopic alterations in late post-operative period and post-operative nasal complaints.
Results
There were 13/14 (92.9%) females with Cushing disease versus 23/42 (54.8%) in the non-functioning adenoma group. Surgical approach was similar in both groups, with no differences in flap usage, turbinectomies or ethmoidectomies. No difference occurred concerning endoscopic alterations or nasal complaints in post-operative period.
Conclusions
Post-operative results are similar, and healing could be expected to be equal.</description><identifier>ISSN: 0937-4477</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/s00405-020-05974-0</identifier><identifier>PMID: 32346754</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adenoma - complications ; Adenoma - surgery ; Endoscopy ; Female ; Head and Neck Surgery ; Humans ; Medicine ; Medicine & Public Health ; Neurosurgery ; Otorhinolaryngology ; Pituitary ACTH Hypersecretion - surgery ; Pituitary Neoplasms - complications ; Pituitary Neoplasms - surgery ; Retrospective Studies ; Short Communication ; Treatment Outcome</subject><ispartof>European archives of oto-rhino-laryngology, 2020-08, Vol.277 (8), p.2371-2374</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-3e730373da3d3f18fb0596d74da212291c4a6d278d82385f6fdc46db3b7a19773</citedby><cites>FETCH-LOGICAL-c347t-3e730373da3d3f18fb0596d74da212291c4a6d278d82385f6fdc46db3b7a19773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00405-020-05974-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00405-020-05974-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32346754$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Toro, Mariana D. C.</creatorcontrib><creatorcontrib>Serrano, Thiago L. I.</creatorcontrib><creatorcontrib>Marson, Fernando A. L.</creatorcontrib><creatorcontrib>Chone, Carlos T.</creatorcontrib><creatorcontrib>Dal Fabbro, Mateus</creatorcontrib><creatorcontrib>Sakano, Eulália</creatorcontrib><creatorcontrib>Sampaio, Marcelo H.</creatorcontrib><title>Comparative analysis of rhinologic outcomes in Cushing disease and non-functioning pituitary adenoma in patients submitted to endoscopic endonasal transsphenoidal surgery</title><title>European archives of oto-rhino-laryngology</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><description>Purpose
Adrenocorticotropic hormone (ACTH) secreted by pituitary tumors lead to changes in nasal cavity anatomy and physiology. As a consequence of hormonal alteration, there is an abnormal soft tissue and an increased capillary fragility, inducting to a thinner mucosa that acts in the healing process. We compared post-operative nasal alterations in patients with Cushing’s disease versus patients with non-functioning macroadenomas who underwent endoscopic endonasal transsphenoidal surgery.
Methods
A retrospective study with 14 patients with Cushing’s disease who underwent initial transsphenoidal endonasal surgery for an ACTH-secreting adenoma was conducted. Forty-two patients who underwent the same surgery for non-functioning adenomas were selected as controls. The following data were collected: operative technique, endoscopic alterations in late post-operative period and post-operative nasal complaints.
Results
There were 13/14 (92.9%) females with Cushing disease versus 23/42 (54.8%) in the non-functioning adenoma group. Surgical approach was similar in both groups, with no differences in flap usage, turbinectomies or ethmoidectomies. No difference occurred concerning endoscopic alterations or nasal complaints in post-operative period.
Conclusions
Post-operative results are similar, and healing could be expected to be equal.</description><subject>Adenoma - complications</subject><subject>Adenoma - surgery</subject><subject>Endoscopy</subject><subject>Female</subject><subject>Head and Neck Surgery</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Otorhinolaryngology</subject><subject>Pituitary ACTH Hypersecretion - surgery</subject><subject>Pituitary Neoplasms - complications</subject><subject>Pituitary Neoplasms - surgery</subject><subject>Retrospective Studies</subject><subject>Short Communication</subject><subject>Treatment Outcome</subject><issn>0937-4477</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-OFCEQxonRuLOrL-DBcPTCSlN0M300E_8lm3jRM2GAnmXTDS0FJvNKPqX0zurRE0W-76tK1Y-QNx2_7ThX75FzyXvGBWe8H5Vk_BnZdRIkk0oMz8mOj6CYlEpdkWvEB855L0d4Sa5AgBxUL3fk9yEtq8mmhF-emmjmMwakaaL5PsQ0p1OwNNVi0-KRhkgPFZtwoi6gN7hFHI0psqlGW0KKm7aGUkMx-UyN8zEtZguubYSPBSnW4xJK8Y6WRH10CW1a25StjAbNTEs2EXG9b9ng2h9rPvl8fkVeTGZG__rpvSE_Pn38fvjC7r59_nr4cMcsSFUYeAUcFDgDDqZuPx3bcQanpDOiE2LsrDSDE2rv9gL2_TRMzsrBHeGoTDcqBTfk3aXvmtPP6rHoJaD182yiTxW1gHEALsSjVVysNifE7Ce95rC0zXXH9cZIXxjpxkg_MtK8hd4-9W-X8O5f5C-UZoCLAZsU2-r6IdXc2OD_2v4B-tGh5g</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Toro, Mariana D. C.</creator><creator>Serrano, Thiago L. I.</creator><creator>Marson, Fernando A. L.</creator><creator>Chone, Carlos T.</creator><creator>Dal Fabbro, Mateus</creator><creator>Sakano, Eulália</creator><creator>Sampaio, Marcelo H.</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200801</creationdate><title>Comparative analysis of rhinologic outcomes in Cushing disease and non-functioning pituitary adenoma in patients submitted to endoscopic endonasal transsphenoidal surgery</title><author>Toro, Mariana D. C. ; Serrano, Thiago L. I. ; Marson, Fernando A. L. ; Chone, Carlos T. ; Dal Fabbro, Mateus ; Sakano, Eulália ; Sampaio, Marcelo H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-3e730373da3d3f18fb0596d74da212291c4a6d278d82385f6fdc46db3b7a19773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adenoma - complications</topic><topic>Adenoma - surgery</topic><topic>Endoscopy</topic><topic>Female</topic><topic>Head and Neck Surgery</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Otorhinolaryngology</topic><topic>Pituitary ACTH Hypersecretion - surgery</topic><topic>Pituitary Neoplasms - complications</topic><topic>Pituitary Neoplasms - surgery</topic><topic>Retrospective Studies</topic><topic>Short Communication</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toro, Mariana D. C.</creatorcontrib><creatorcontrib>Serrano, Thiago L. I.</creatorcontrib><creatorcontrib>Marson, Fernando A. L.</creatorcontrib><creatorcontrib>Chone, Carlos T.</creatorcontrib><creatorcontrib>Dal Fabbro, Mateus</creatorcontrib><creatorcontrib>Sakano, Eulália</creatorcontrib><creatorcontrib>Sampaio, Marcelo H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of oto-rhino-laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toro, Mariana D. C.</au><au>Serrano, Thiago L. I.</au><au>Marson, Fernando A. L.</au><au>Chone, Carlos T.</au><au>Dal Fabbro, Mateus</au><au>Sakano, Eulália</au><au>Sampaio, Marcelo H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative analysis of rhinologic outcomes in Cushing disease and non-functioning pituitary adenoma in patients submitted to endoscopic endonasal transsphenoidal surgery</atitle><jtitle>European archives of oto-rhino-laryngology</jtitle><stitle>Eur Arch Otorhinolaryngol</stitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>277</volume><issue>8</issue><spage>2371</spage><epage>2374</epage><pages>2371-2374</pages><issn>0937-4477</issn><eissn>1434-4726</eissn><abstract>Purpose
Adrenocorticotropic hormone (ACTH) secreted by pituitary tumors lead to changes in nasal cavity anatomy and physiology. As a consequence of hormonal alteration, there is an abnormal soft tissue and an increased capillary fragility, inducting to a thinner mucosa that acts in the healing process. We compared post-operative nasal alterations in patients with Cushing’s disease versus patients with non-functioning macroadenomas who underwent endoscopic endonasal transsphenoidal surgery.
Methods
A retrospective study with 14 patients with Cushing’s disease who underwent initial transsphenoidal endonasal surgery for an ACTH-secreting adenoma was conducted. Forty-two patients who underwent the same surgery for non-functioning adenomas were selected as controls. The following data were collected: operative technique, endoscopic alterations in late post-operative period and post-operative nasal complaints.
Results
There were 13/14 (92.9%) females with Cushing disease versus 23/42 (54.8%) in the non-functioning adenoma group. Surgical approach was similar in both groups, with no differences in flap usage, turbinectomies or ethmoidectomies. No difference occurred concerning endoscopic alterations or nasal complaints in post-operative period.
Conclusions
Post-operative results are similar, and healing could be expected to be equal.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32346754</pmid><doi>10.1007/s00405-020-05974-0</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adenoma - complications Adenoma - surgery Endoscopy Female Head and Neck Surgery Humans Medicine Medicine & Public Health Neurosurgery Otorhinolaryngology Pituitary ACTH Hypersecretion - surgery Pituitary Neoplasms - complications Pituitary Neoplasms - surgery Retrospective Studies Short Communication Treatment Outcome |
| title | Comparative analysis of rhinologic outcomes in Cushing disease and non-functioning pituitary adenoma in patients submitted to endoscopic endonasal transsphenoidal surgery |
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