Sarcopenia in people living with the Human Immunodeficiency Virus: a systematic review and meta-analysis
People living with HIV (PLHIV) experience greater loss of muscle mass and function than people without HIV. However, HIV is not routinely recognized as a sarcopenia risk factor outside of HIV literature. The purposes of this study were to establish the prevalence and predictors of sarcopenia among P...
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| Veröffentlicht in: | European journal of clinical nutrition 2020-07, Vol.74 (7), p.1009-1021 |
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| creator | Oliveira, Vitor H. F. Borsari, Ana L. Webel, Allison R. Erlandson, Kristine M. Deminice, Rafael |
| description | People living with HIV (PLHIV) experience greater loss of muscle mass and function than people without HIV. However, HIV is not routinely recognized as a sarcopenia risk factor outside of HIV literature. The purposes of this study were to establish the prevalence and predictors of sarcopenia among PLHIV, and to compare the prevalence of sarcopenia among PLHIV and people without HIV. A systematic literature search of the PubMed, Embase, Cinahl, and Scielo databases was performed following PRISMA and MOOSE guidelines. Identified articles were included if they evaluated sarcopenia among PLHIV using either the presence of low muscle mass only or low muscle mass in association with low muscle function. The pooled prevalence of sarcopenia among PLHIV and the odds ratio for sarcopenia in PLHIV compared with controls were calculated. From 13 studies and 2267 participants, the prevalence of sarcopenia among PLHIV was 24.1% (95% CI = 17.8–31.0%). PLHIV presented 6.1 greater odds (95% CI = 1.1–33.5) of sarcopenia compared with people without HIV, matched by age, sex, BMI, and ethnicity. Longer exposure to specific HIV drugs, tobacco and alcohol, lower education and employment rates, and greater HIV duration were associated with sarcopenia. In conclusion, PLHIV had a high prevalence of sarcopenia, related to both HIV and non-HIV risk factors. HIV should be considered a risk factor for sarcopenia in the general population. CRD42019131449. |
| doi_str_mv | 10.1038/s41430-020-0637-0 |
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F. ; Borsari, Ana L. ; Webel, Allison R. ; Erlandson, Kristine M. ; Deminice, Rafael</creator><creatorcontrib>Oliveira, Vitor H. F. ; Borsari, Ana L. ; Webel, Allison R. ; Erlandson, Kristine M. ; Deminice, Rafael</creatorcontrib><description>People living with HIV (PLHIV) experience greater loss of muscle mass and function than people without HIV. However, HIV is not routinely recognized as a sarcopenia risk factor outside of HIV literature. The purposes of this study were to establish the prevalence and predictors of sarcopenia among PLHIV, and to compare the prevalence of sarcopenia among PLHIV and people without HIV. A systematic literature search of the PubMed, Embase, Cinahl, and Scielo databases was performed following PRISMA and MOOSE guidelines. Identified articles were included if they evaluated sarcopenia among PLHIV using either the presence of low muscle mass only or low muscle mass in association with low muscle function. The pooled prevalence of sarcopenia among PLHIV and the odds ratio for sarcopenia in PLHIV compared with controls were calculated. From 13 studies and 2267 participants, the prevalence of sarcopenia among PLHIV was 24.1% (95% CI = 17.8–31.0%). PLHIV presented 6.1 greater odds (95% CI = 1.1–33.5) of sarcopenia compared with people without HIV, matched by age, sex, BMI, and ethnicity. Longer exposure to specific HIV drugs, tobacco and alcohol, lower education and employment rates, and greater HIV duration were associated with sarcopenia. In conclusion, PLHIV had a high prevalence of sarcopenia, related to both HIV and non-HIV risk factors. HIV should be considered a risk factor for sarcopenia in the general population. 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F.</creatorcontrib><creatorcontrib>Borsari, Ana L.</creatorcontrib><creatorcontrib>Webel, Allison R.</creatorcontrib><creatorcontrib>Erlandson, Kristine M.</creatorcontrib><creatorcontrib>Deminice, Rafael</creatorcontrib><title>Sarcopenia in people living with the Human Immunodeficiency Virus: a systematic review and meta-analysis</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>People living with HIV (PLHIV) experience greater loss of muscle mass and function than people without HIV. However, HIV is not routinely recognized as a sarcopenia risk factor outside of HIV literature. The purposes of this study were to establish the prevalence and predictors of sarcopenia among PLHIV, and to compare the prevalence of sarcopenia among PLHIV and people without HIV. A systematic literature search of the PubMed, Embase, Cinahl, and Scielo databases was performed following PRISMA and MOOSE guidelines. Identified articles were included if they evaluated sarcopenia among PLHIV using either the presence of low muscle mass only or low muscle mass in association with low muscle function. The pooled prevalence of sarcopenia among PLHIV and the odds ratio for sarcopenia in PLHIV compared with controls were calculated. From 13 studies and 2267 participants, the prevalence of sarcopenia among PLHIV was 24.1% (95% CI = 17.8–31.0%). PLHIV presented 6.1 greater odds (95% CI = 1.1–33.5) of sarcopenia compared with people without HIV, matched by age, sex, BMI, and ethnicity. Longer exposure to specific HIV drugs, tobacco and alcohol, lower education and employment rates, and greater HIV duration were associated with sarcopenia. In conclusion, PLHIV had a high prevalence of sarcopenia, related to both HIV and non-HIV risk factors. HIV should be considered a risk factor for sarcopenia in the general population. 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F.</au><au>Borsari, Ana L.</au><au>Webel, Allison R.</au><au>Erlandson, Kristine M.</au><au>Deminice, Rafael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sarcopenia in people living with the Human Immunodeficiency Virus: a systematic review and meta-analysis</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>74</volume><issue>7</issue><spage>1009</spage><epage>1021</epage><pages>1009-1021</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>People living with HIV (PLHIV) experience greater loss of muscle mass and function than people without HIV. However, HIV is not routinely recognized as a sarcopenia risk factor outside of HIV literature. 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Longer exposure to specific HIV drugs, tobacco and alcohol, lower education and employment rates, and greater HIV duration were associated with sarcopenia. In conclusion, PLHIV had a high prevalence of sarcopenia, related to both HIV and non-HIV risk factors. HIV should be considered a risk factor for sarcopenia in the general population. CRD42019131449.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32341489</pmid><doi>10.1038/s41430-020-0637-0</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/499 692/699/255/1901 Analysis Clinical Nutrition Epidemiology Health risks HIV HIV (Viruses) Human immunodeficiency virus Internal Medicine Medicine Medicine & Public Health Meta-analysis Metabolic Diseases Muscles Public Health Review Article Risk analysis Risk factors Sarcopenia Sexually transmitted diseases STD Tobacco Viruses |
| title | Sarcopenia in people living with the Human Immunodeficiency Virus: a systematic review and meta-analysis |
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