Design and synthesis of novel proline based factor XIa selective inhibitors as leads for potential new anticoagulants

[Display omitted] A series of 4, 4-disubstituted proline analogs were designed, synthesized, and tested for selective inhibition of blood coagulation factor XIa in search of new non-vitamin K antagonists based oral anticoagulants for potential prevention and treatment of thrombotic diseases. Startin...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2020-08, Vol.30 (16), p.127072-127072, Article 127072
Hauptverfasser:	Hussain, Zahid, Cooke, Andrew J., Neelamkavil, Santhosh, Brown, Lindsay, Carswell, Emma, Geissler, Wayne M., Guo, Zhuyan, Hawes, Brian, Kelly, Terri M., Kiyoi, Yasuko, Lai, KehDih, Lesburg, Charles, Pow, Eleanor, Zang, Yi, Wood, Harold B., Edmondson, Scott D., Liu, Weiguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants Factor XIa (FXIa) inhibitor Proline analogs Thrombin (FIIa) Thrombosis
Online-Zugang:	Volltext
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