Synthetic Approaches to New Drugs Approved during 2018

Synthetic Approaches to New Drugs Approved during 2018

New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition while serving as leads for designing future new drugs. This annual review describes the most likely process-s...

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Veröffentlicht in:Journal of medicinal chemistry 2020-10, Vol.63 (19), p.10652-10704
Hauptverfasser: Flick, Andrew C, Leverett, Carolyn A, Ding, Hong X, McInturff, Emma, Fink, Sarah J, Helal, Christopher J, DeForest, Jacob C, Morse, Peter D, Mahapatra, Subham, O’Donnell, Christopher J
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Drug Approval
Drug Discovery
History, 21st Century
Molecular Structure
Pharmaceutical Preparations - chemistry
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container_end_page 10704
container_issue 19
container_start_page 10652
container_title Journal of medicinal chemistry
container_volume 63
creator Flick, Andrew C
Leverett, Carolyn A
Ding, Hong X
McInturff, Emma
Fink, Sarah J
Helal, Christopher J
DeForest, Jacob C
Morse, Peter D
Mahapatra, Subham
O’Donnell, Christopher J
description New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition while serving as leads for designing future new drugs. This annual review describes the most likely process-scale synthetic approaches to 39 new chemical entities approved for the first time globally in 2018.
doi_str_mv 10.1021/acs.jmedchem.0c00345
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subjects Drug Approval
Drug Discovery
History, 21st Century
Molecular Structure
Pharmaceutical Preparations - chemistry
title Synthetic Approaches to New Drugs Approved during 2018
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