Pooling, room temperature, and extended storage time increase the release of adult‐specific biologic response modifiers in platelet concentrates: a hidden transfusion risk for neonates?

BACKGROUND Adult donor platelets (PLTs) are frequently transfused to prevent or stop bleeding in neonates with thrombocytopenia. There is evidence for PLT transfusion–related morbidity and mortality, leading to the hypothesis on immunomodulatory effects of transfusing adult PLTs into neonates. Candi...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2020-08, Vol.60 (8), p.1828-1836
Hauptverfasser:	Waubert de Puiseau, Miriam, Sciesielski, Lina K., Meyer, Oliver, Liu, Zhi‐Jian, Badur, Chiara‐Aiyleen, Schönfeld, Helge, Tauber, Rudolf, Pruß, Axel, Sola‐Visner, Martha C., Dame, Christof
Format:	Artikel
Sprache:	eng
Schlagworte:	Apheresis Bleeding Cold storage Dkk1 protein Immunomodulation Light transmission Morbidity Neonates Platelets RANTES Room temperature Storage conditions Thrombocytopenia Transforming growth factor-b1 Transfusion
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