Obstetric outcomes of twin pregnancies presenting with a complete hydatidiform mole and coexistent normal fetus: a systematic review and meta‐analysis
Background Epidemiological data on obstetric and oncologic complications in twin pregnancies combining a complete hydatidiform mole (CHM) coexisting with a normal fetus and placenta are limited. Objectives To evaluate perinatal and obstetric outcomes for mother and fetus and risk of gestational trop...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 2020-11, Vol.127 (12), p.1450-1457 |
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| creator | Zilberman Sharon, N Maymon, R Melcer, Y Jauniaux, E |
| description | Background
Epidemiological data on obstetric and oncologic complications in twin pregnancies combining a complete hydatidiform mole (CHM) coexisting with a normal fetus and placenta are limited.
Objectives
To evaluate perinatal and obstetric outcomes for mother and fetus and risk of gestational trophoblastic neoplasia (GTN) in twin pregnancies including a CHM.
Search strategy
PubMed, MEDLINE and EMBASE and the grey literature were searched for articles published between May 1980 and May 2019 using a protocol designed a priori and registered on PROSPERO (CRD42018112524).
Selection criteria
Observational cohort studies of four or more cases confirmed by histopathology and providing data on pregnancy outcomes and GTN.
Data collection and analysis
Two reviewers independently reviewed s and full‐text articles. The quality of the studies was assessed with the Newcastle‐Ottawa scale and a meta‐analysis was performed.
Main results
Of the 344 s identified, 14 studies (244 cases) met the eligibility criteria. The incidence of maternal complication in ongoing pregnancies was 80.8% and included vaginal bleeding, hyperthyroidism and pre‐eclampsia. There were overall 91 (50%) live births in ongoing pregnancies and 83 (34%) of the total cases were subsequently diagnosed with GTN. Substantial and significant (P |
| doi_str_mv | 10.1111/1471-0528.16283 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2395611431</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2449453499</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4123-a1c4ef6c591cfd052d98d6c6ecefeca69ba1dee3101179d921f6cac82d70d5333</originalsourceid><addsrcrecordid>eNqFkb1uFDEUhS1EREKgpkOWaGgmscee2TEdROEnirQN1JbXvpM4mrEX25NlOh4hJc_Hk3B3N0mRBje-Ovc7R7YOIW84O-F4Trlc8Io1dXfC27oTz8jRo_J8N7OKibo7JC9zvmEMISZekENRC6GkbI_In-UqFyjJWxqnYuMImcaelo0PdJ3gKphgPWo4ZwjFhyu68eWaGorseoAC9Hp2pnjn-5hGOsYBqAkO1_DLY3QoNODCDLSHMuUP6Mwz6iN6LE1w62GzM4xQzN_fdyaYYc4-vyIHvRkyvL6_j8mPz-ffz75Wl8sv384-XlZW8lpUhlsJfWsbxW3v8N9Oda61LVjowZpWrQx3AIIzzhfKqZojbGxXuwVzjRDimLzf565T_DlBLnr02cIwmABxyroWqmk5l4Ij-u4JehOnhO9FSkolGyGVQup0T9kUc07Q63Xyo0mz5kxvS9PbivS2Ir0rDR1v73On1QjukX9oCYFmD2z8APP_8vSni-U--B_gXaXR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2449453499</pqid></control><display><type>article</type><title>Obstetric outcomes of twin pregnancies presenting with a complete hydatidiform mole and coexistent normal fetus: a systematic review and meta‐analysis</title><source>Wiley Online Library All Journals</source><creator>Zilberman Sharon, N ; Maymon, R ; Melcer, Y ; Jauniaux, E</creator><creatorcontrib>Zilberman Sharon, N ; Maymon, R ; Melcer, Y ; Jauniaux, E</creatorcontrib><description>Background
Epidemiological data on obstetric and oncologic complications in twin pregnancies combining a complete hydatidiform mole (CHM) coexisting with a normal fetus and placenta are limited.
Objectives
To evaluate perinatal and obstetric outcomes for mother and fetus and risk of gestational trophoblastic neoplasia (GTN) in twin pregnancies including a CHM.
Search strategy
PubMed, MEDLINE and EMBASE and the grey literature were searched for articles published between May 1980 and May 2019 using a protocol designed a priori and registered on PROSPERO (CRD42018112524).
Selection criteria
Observational cohort studies of four or more cases confirmed by histopathology and providing data on pregnancy outcomes and GTN.
Data collection and analysis
Two reviewers independently reviewed s and full‐text articles. The quality of the studies was assessed with the Newcastle‐Ottawa scale and a meta‐analysis was performed.
Main results
Of the 344 s identified, 14 studies (244 cases) met the eligibility criteria. The incidence of maternal complication in ongoing pregnancies was 80.8% and included vaginal bleeding, hyperthyroidism and pre‐eclampsia. There were overall 91 (50%) live births in ongoing pregnancies and 83 (34%) of the total cases were subsequently diagnosed with GTN. Substantial and significant (P < 0.001) heterogeneity was found for the incidence of preeclampsia indicating variability in reporting the incidence of some obstetric complications between studies.
Conclusions
Patients diagnosed with a twin pregnancy combining a CHM and an apparently normal fetus have a high risk of perinatal complications, low live‐birth rates and around a third of them will develop a GTN and should be managed by specialised multidisciplinary teams.
Tweetable
Our study indicates a high rate of obstetric and oncologic complications in patients presenting with a complete hydatidiform mole and coexistent normal fetus.
Tweetable
Our study indicates a high rate of obstetric and oncologic complications in patients presenting with a complete hydatidiform mole and coexistent normal fetus.</description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/1471-0528.16283</identifier><identifier>PMID: 32339446</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Complete hydatidiform mole ; Data collection ; Epidemiology ; Fetuses ; gestational trophoblastic neoplasia ; Hydatidiform mole ; Hyperthyroidism ; Meta-analysis ; Obstetrics ; Placenta ; Pre-eclampsia ; Pregnancy ; Pregnancy complications ; systematic review ; twins ; Vagina</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2020-11, Vol.127 (12), p.1450-1457</ispartof><rights>2020 The Authors. published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists</rights><rights>2020 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4123-a1c4ef6c591cfd052d98d6c6ecefeca69ba1dee3101179d921f6cac82d70d5333</citedby><cites>FETCH-LOGICAL-c4123-a1c4ef6c591cfd052d98d6c6ecefeca69ba1dee3101179d921f6cac82d70d5333</cites><orcidid>0000-0001-6834-2718 ; 0000-0003-0925-7737</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1471-0528.16283$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1471-0528.16283$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32339446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zilberman Sharon, N</creatorcontrib><creatorcontrib>Maymon, R</creatorcontrib><creatorcontrib>Melcer, Y</creatorcontrib><creatorcontrib>Jauniaux, E</creatorcontrib><title>Obstetric outcomes of twin pregnancies presenting with a complete hydatidiform mole and coexistent normal fetus: a systematic review and meta‐analysis</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Background
Epidemiological data on obstetric and oncologic complications in twin pregnancies combining a complete hydatidiform mole (CHM) coexisting with a normal fetus and placenta are limited.
Objectives
To evaluate perinatal and obstetric outcomes for mother and fetus and risk of gestational trophoblastic neoplasia (GTN) in twin pregnancies including a CHM.
Search strategy
PubMed, MEDLINE and EMBASE and the grey literature were searched for articles published between May 1980 and May 2019 using a protocol designed a priori and registered on PROSPERO (CRD42018112524).
Selection criteria
Observational cohort studies of four or more cases confirmed by histopathology and providing data on pregnancy outcomes and GTN.
Data collection and analysis
Two reviewers independently reviewed s and full‐text articles. The quality of the studies was assessed with the Newcastle‐Ottawa scale and a meta‐analysis was performed.
Main results
Of the 344 s identified, 14 studies (244 cases) met the eligibility criteria. The incidence of maternal complication in ongoing pregnancies was 80.8% and included vaginal bleeding, hyperthyroidism and pre‐eclampsia. There were overall 91 (50%) live births in ongoing pregnancies and 83 (34%) of the total cases were subsequently diagnosed with GTN. Substantial and significant (P < 0.001) heterogeneity was found for the incidence of preeclampsia indicating variability in reporting the incidence of some obstetric complications between studies.
Conclusions
Patients diagnosed with a twin pregnancy combining a CHM and an apparently normal fetus have a high risk of perinatal complications, low live‐birth rates and around a third of them will develop a GTN and should be managed by specialised multidisciplinary teams.
Tweetable
Our study indicates a high rate of obstetric and oncologic complications in patients presenting with a complete hydatidiform mole and coexistent normal fetus.
Tweetable
Our study indicates a high rate of obstetric and oncologic complications in patients presenting with a complete hydatidiform mole and coexistent normal fetus.</description><subject>Complete hydatidiform mole</subject><subject>Data collection</subject><subject>Epidemiology</subject><subject>Fetuses</subject><subject>gestational trophoblastic neoplasia</subject><subject>Hydatidiform mole</subject><subject>Hyperthyroidism</subject><subject>Meta-analysis</subject><subject>Obstetrics</subject><subject>Placenta</subject><subject>Pre-eclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>systematic review</subject><subject>twins</subject><subject>Vagina</subject><issn>1470-0328</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNqFkb1uFDEUhS1EREKgpkOWaGgmscee2TEdROEnirQN1JbXvpM4mrEX25NlOh4hJc_Hk3B3N0mRBje-Ovc7R7YOIW84O-F4Trlc8Io1dXfC27oTz8jRo_J8N7OKibo7JC9zvmEMISZekENRC6GkbI_In-UqFyjJWxqnYuMImcaelo0PdJ3gKphgPWo4ZwjFhyu68eWaGorseoAC9Hp2pnjn-5hGOsYBqAkO1_DLY3QoNODCDLSHMuUP6Mwz6iN6LE1w62GzM4xQzN_fdyaYYc4-vyIHvRkyvL6_j8mPz-ffz75Wl8sv384-XlZW8lpUhlsJfWsbxW3v8N9Oda61LVjowZpWrQx3AIIzzhfKqZojbGxXuwVzjRDimLzf565T_DlBLnr02cIwmABxyroWqmk5l4Ij-u4JehOnhO9FSkolGyGVQup0T9kUc07Q63Xyo0mz5kxvS9PbivS2Ir0rDR1v73On1QjukX9oCYFmD2z8APP_8vSni-U--B_gXaXR</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Zilberman Sharon, N</creator><creator>Maymon, R</creator><creator>Melcer, Y</creator><creator>Jauniaux, E</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6834-2718</orcidid><orcidid>https://orcid.org/0000-0003-0925-7737</orcidid></search><sort><creationdate>202011</creationdate><title>Obstetric outcomes of twin pregnancies presenting with a complete hydatidiform mole and coexistent normal fetus: a systematic review and meta‐analysis</title><author>Zilberman Sharon, N ; Maymon, R ; Melcer, Y ; Jauniaux, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4123-a1c4ef6c591cfd052d98d6c6ecefeca69ba1dee3101179d921f6cac82d70d5333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Complete hydatidiform mole</topic><topic>Data collection</topic><topic>Epidemiology</topic><topic>Fetuses</topic><topic>gestational trophoblastic neoplasia</topic><topic>Hydatidiform mole</topic><topic>Hyperthyroidism</topic><topic>Meta-analysis</topic><topic>Obstetrics</topic><topic>Placenta</topic><topic>Pre-eclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>systematic review</topic><topic>twins</topic><topic>Vagina</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zilberman Sharon, N</creatorcontrib><creatorcontrib>Maymon, R</creatorcontrib><creatorcontrib>Melcer, Y</creatorcontrib><creatorcontrib>Jauniaux, E</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zilberman Sharon, N</au><au>Maymon, R</au><au>Melcer, Y</au><au>Jauniaux, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obstetric outcomes of twin pregnancies presenting with a complete hydatidiform mole and coexistent normal fetus: a systematic review and meta‐analysis</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>BJOG</addtitle><date>2020-11</date><risdate>2020</risdate><volume>127</volume><issue>12</issue><spage>1450</spage><epage>1457</epage><pages>1450-1457</pages><issn>1470-0328</issn><eissn>1471-0528</eissn><abstract>Background
Epidemiological data on obstetric and oncologic complications in twin pregnancies combining a complete hydatidiform mole (CHM) coexisting with a normal fetus and placenta are limited.
Objectives
To evaluate perinatal and obstetric outcomes for mother and fetus and risk of gestational trophoblastic neoplasia (GTN) in twin pregnancies including a CHM.
Search strategy
PubMed, MEDLINE and EMBASE and the grey literature were searched for articles published between May 1980 and May 2019 using a protocol designed a priori and registered on PROSPERO (CRD42018112524).
Selection criteria
Observational cohort studies of four or more cases confirmed by histopathology and providing data on pregnancy outcomes and GTN.
Data collection and analysis
Two reviewers independently reviewed s and full‐text articles. The quality of the studies was assessed with the Newcastle‐Ottawa scale and a meta‐analysis was performed.
Main results
Of the 344 s identified, 14 studies (244 cases) met the eligibility criteria. The incidence of maternal complication in ongoing pregnancies was 80.8% and included vaginal bleeding, hyperthyroidism and pre‐eclampsia. There were overall 91 (50%) live births in ongoing pregnancies and 83 (34%) of the total cases were subsequently diagnosed with GTN. Substantial and significant (P < 0.001) heterogeneity was found for the incidence of preeclampsia indicating variability in reporting the incidence of some obstetric complications between studies.
Conclusions
Patients diagnosed with a twin pregnancy combining a CHM and an apparently normal fetus have a high risk of perinatal complications, low live‐birth rates and around a third of them will develop a GTN and should be managed by specialised multidisciplinary teams.
Tweetable
Our study indicates a high rate of obstetric and oncologic complications in patients presenting with a complete hydatidiform mole and coexistent normal fetus.
Tweetable
Our study indicates a high rate of obstetric and oncologic complications in patients presenting with a complete hydatidiform mole and coexistent normal fetus.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32339446</pmid><doi>10.1111/1471-0528.16283</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6834-2718</orcidid><orcidid>https://orcid.org/0000-0003-0925-7737</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1470-0328 |
| ispartof | BJOG : an international journal of obstetrics and gynaecology, 2020-11, Vol.127 (12), p.1450-1457 |
| issn | 1470-0328 1471-0528 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2395611431 |
| source | Wiley Online Library All Journals |
| subjects | Complete hydatidiform mole Data collection Epidemiology Fetuses gestational trophoblastic neoplasia Hydatidiform mole Hyperthyroidism Meta-analysis Obstetrics Placenta Pre-eclampsia Pregnancy Pregnancy complications systematic review twins Vagina |
| title | Obstetric outcomes of twin pregnancies presenting with a complete hydatidiform mole and coexistent normal fetus: a systematic review and meta‐analysis |
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