Personality factors and cerebral glucose metabolism in community-dwelling older adults
Personality factors have been associated with Alzheimer’s disease (AD) and dementia, but they have not been examined against markers of regional brain glucose metabolism (a primary measure of brain functioning) in older adults without clinically diagnosed cognitive impairment. The relationship betwe...
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| creator | Sohrabi, Hamid R. Goozee, Kathryn Weinborn, Michael Shen, Kaikai Brown, Belinda M. Rainey-Smith, Stephanie R. Salvado, Olivier Taddei, Kevin Bucks, Romola S. Maruff, Paul Laws, Simon M. Lenzo, Nat Laws, Manja DeYoung, Colin Speelman, Craig Laske, Christoph Ames, David Savage, Greg Martins, Ralph N. |
| description | Personality factors have been associated with Alzheimer’s disease (AD) and dementia, but they have not been examined against markers of regional brain glucose metabolism (a primary measure of brain functioning) in older adults without clinically diagnosed cognitive impairment. The relationship between personality factors derived from the five-factor model and cerebral glucose metabolism determined using positron emission tomography (PET) with [18F]-2-fluoro-2-deoxy-
d
-glucose (18F-FDG-PET) was examined in a cohort of 237 non-demented, community-dwelling older adults aged 60–89 years (M ± SD = 73.76 ± 6.73). Higher neuroticism and lower scores on extraversion and conscientiousness were significantly associated with decreased glucose metabolism in brain regions typically affected by AD neuropathological processes, including the hippocampus and entorhinal cortex. Furthermore, while there were significant differences between apolipoprotein E (
APOE
) ε4 allele carriers and non-carriers on
18
F-FDG-PET results in the neocortex and other brain regions (
p
|
| doi_str_mv | 10.1007/s00429-020-02071-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2395605592</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2395605592</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-58a3e124aa796c2bef467c336e8bbbb2babd39053fc9588f78bf1ed8dfc48e173</originalsourceid><addsrcrecordid>eNp9kE1LwzAch4MoOqdfwIMEvHip5qVpk6MM32CgB_Ua0vTf0ZE2M2mRfXszNxU8GAgJ5Pn9kjwInVFyRQkpryMhOVMZYWQzS5qRPTShsuAZKwq6_7MX_Agdx7gkRChJ1SE64oznjDExQW_PEKLvjWuHNW6MHXyI2PQ1thCgCsbhhRutj4A7GEzlXRs73PbY-q4b-xTK6g9wru0X2LsaAjb16IZ4gg4a4yKc7tYper27fZk9ZPOn-8fZzTyzvBRDJqThQFluTKkKyypo8qK0nBcgqzRYZaqaKyJ4Y5WQsill1VCoZd3YXAIt-RRdbntXwb-PEAfdtdGmB5ke_Bg140oURAjFEnrxB136MaSfJyqnNOdUUZkotqVs8DEGaPQqtJ0Ja02J3ljXW-s6Gddf1jVJofNd9Vh1UP9EvjUngG-BmI76BYTfu_-p_QQYBY4b</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2411431918</pqid></control><display><type>article</type><title>Personality factors and cerebral glucose metabolism in community-dwelling older adults</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Sohrabi, Hamid R. ; Goozee, Kathryn ; Weinborn, Michael ; Shen, Kaikai ; Brown, Belinda M. ; Rainey-Smith, Stephanie R. ; Salvado, Olivier ; Taddei, Kevin ; Bucks, Romola S. ; Maruff, Paul ; Laws, Simon M. ; Lenzo, Nat ; Laws, Manja ; DeYoung, Colin ; Speelman, Craig ; Laske, Christoph ; Ames, David ; Savage, Greg ; Martins, Ralph N.</creator><creatorcontrib>Sohrabi, Hamid R. ; Goozee, Kathryn ; Weinborn, Michael ; Shen, Kaikai ; Brown, Belinda M. ; Rainey-Smith, Stephanie R. ; Salvado, Olivier ; Taddei, Kevin ; Bucks, Romola S. ; Maruff, Paul ; Laws, Simon M. ; Lenzo, Nat ; Laws, Manja ; DeYoung, Colin ; Speelman, Craig ; Laske, Christoph ; Ames, David ; Savage, Greg ; Martins, Ralph N.</creatorcontrib><description>Personality factors have been associated with Alzheimer’s disease (AD) and dementia, but they have not been examined against markers of regional brain glucose metabolism (a primary measure of brain functioning) in older adults without clinically diagnosed cognitive impairment. The relationship between personality factors derived from the five-factor model and cerebral glucose metabolism determined using positron emission tomography (PET) with [18F]-2-fluoro-2-deoxy-
d
-glucose (18F-FDG-PET) was examined in a cohort of 237 non-demented, community-dwelling older adults aged 60–89 years (M ± SD = 73.76 ± 6.73). Higher neuroticism and lower scores on extraversion and conscientiousness were significantly associated with decreased glucose metabolism in brain regions typically affected by AD neuropathological processes, including the hippocampus and entorhinal cortex. Furthermore, while there were significant differences between apolipoprotein E (
APOE
) ε4 allele carriers and non-carriers on
18
F-FDG-PET results in the neocortex and other brain regions (
p
< 0.05), there was no significant difference between carriers and non-carriers on personality factors and no significant interactions were found between
APOE
ε4 carriage and personality factors on brain glucose metabolism. In conclusion, we found significant relationships between personality factors and glucose metabolism in neural regions more susceptible to AD neuropathology in older adults without clinically significant cognitive impairment. These findings support the need for longitudinal research into the potential mechanisms underlying the relationship between personality and dementia risk, including measurement of change in other AD biomarkers (amyloid and tau imaging) and how they correspond to change in personality factors. Future research is also warranted to determine whether timely psychological interventions aimed at personality facets (specific aspects or characteristics of personality factors) can affect imaging or other biomarkers of AD resulting in delay or ideally preventing the onset of the cognitive impairment.</description><identifier>ISSN: 1863-2653</identifier><identifier>EISSN: 1863-2661</identifier><identifier>EISSN: 0340-2061</identifier><identifier>DOI: 10.1007/s00429-020-02071-0</identifier><identifier>PMID: 32342225</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer's disease ; Apolipoprotein E ; Apolipoprotein E4 - genetics ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Brain research ; Cell Biology ; Cerebral Cortex - metabolism ; Clinical significance ; Cognitive ability ; Cortex (entorhinal) ; Cross-Sectional Studies ; Dementia ; Dementia disorders ; Female ; Genotype ; Glucose ; Glucose - metabolism ; Humans ; Independent Living ; Male ; Metabolism ; Middle Aged ; Neocortex ; Neurodegenerative diseases ; Neuroimaging ; Neurology ; Neurosciences ; Neurosis ; Older people ; Original Article ; Personality ; Personality - physiology ; Personality Tests ; Positron emission tomography ; Tau protein</subject><ispartof>Brain Structure and Function, 2020-06, Vol.225 (5), p.1511-1522</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-58a3e124aa796c2bef467c336e8bbbb2babd39053fc9588f78bf1ed8dfc48e173</citedby><cites>FETCH-LOGICAL-c375t-58a3e124aa796c2bef467c336e8bbbb2babd39053fc9588f78bf1ed8dfc48e173</cites><orcidid>0000-0001-8017-8682</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00429-020-02071-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00429-020-02071-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32342225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sohrabi, Hamid R.</creatorcontrib><creatorcontrib>Goozee, Kathryn</creatorcontrib><creatorcontrib>Weinborn, Michael</creatorcontrib><creatorcontrib>Shen, Kaikai</creatorcontrib><creatorcontrib>Brown, Belinda M.</creatorcontrib><creatorcontrib>Rainey-Smith, Stephanie R.</creatorcontrib><creatorcontrib>Salvado, Olivier</creatorcontrib><creatorcontrib>Taddei, Kevin</creatorcontrib><creatorcontrib>Bucks, Romola S.</creatorcontrib><creatorcontrib>Maruff, Paul</creatorcontrib><creatorcontrib>Laws, Simon M.</creatorcontrib><creatorcontrib>Lenzo, Nat</creatorcontrib><creatorcontrib>Laws, Manja</creatorcontrib><creatorcontrib>DeYoung, Colin</creatorcontrib><creatorcontrib>Speelman, Craig</creatorcontrib><creatorcontrib>Laske, Christoph</creatorcontrib><creatorcontrib>Ames, David</creatorcontrib><creatorcontrib>Savage, Greg</creatorcontrib><creatorcontrib>Martins, Ralph N.</creatorcontrib><title>Personality factors and cerebral glucose metabolism in community-dwelling older adults</title><title>Brain Structure and Function</title><addtitle>Brain Struct Funct</addtitle><addtitle>Brain Struct Funct</addtitle><description>Personality factors have been associated with Alzheimer’s disease (AD) and dementia, but they have not been examined against markers of regional brain glucose metabolism (a primary measure of brain functioning) in older adults without clinically diagnosed cognitive impairment. The relationship between personality factors derived from the five-factor model and cerebral glucose metabolism determined using positron emission tomography (PET) with [18F]-2-fluoro-2-deoxy-
d
-glucose (18F-FDG-PET) was examined in a cohort of 237 non-demented, community-dwelling older adults aged 60–89 years (M ± SD = 73.76 ± 6.73). Higher neuroticism and lower scores on extraversion and conscientiousness were significantly associated with decreased glucose metabolism in brain regions typically affected by AD neuropathological processes, including the hippocampus and entorhinal cortex. Furthermore, while there were significant differences between apolipoprotein E (
APOE
) ε4 allele carriers and non-carriers on
18
F-FDG-PET results in the neocortex and other brain regions (
p
< 0.05), there was no significant difference between carriers and non-carriers on personality factors and no significant interactions were found between
APOE
ε4 carriage and personality factors on brain glucose metabolism. In conclusion, we found significant relationships between personality factors and glucose metabolism in neural regions more susceptible to AD neuropathology in older adults without clinically significant cognitive impairment. These findings support the need for longitudinal research into the potential mechanisms underlying the relationship between personality and dementia risk, including measurement of change in other AD biomarkers (amyloid and tau imaging) and how they correspond to change in personality factors. Future research is also warranted to determine whether timely psychological interventions aimed at personality facets (specific aspects or characteristics of personality factors) can affect imaging or other biomarkers of AD resulting in delay or ideally preventing the onset of the cognitive impairment.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer's disease</subject><subject>Apolipoprotein E</subject><subject>Apolipoprotein E4 - genetics</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain research</subject><subject>Cell Biology</subject><subject>Cerebral Cortex - metabolism</subject><subject>Clinical significance</subject><subject>Cognitive ability</subject><subject>Cortex (entorhinal)</subject><subject>Cross-Sectional Studies</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Female</subject><subject>Genotype</subject><subject>Glucose</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Independent Living</subject><subject>Male</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Neocortex</subject><subject>Neurodegenerative diseases</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Neurosis</subject><subject>Older people</subject><subject>Original Article</subject><subject>Personality</subject><subject>Personality - physiology</subject><subject>Personality Tests</subject><subject>Positron emission tomography</subject><subject>Tau protein</subject><issn>1863-2653</issn><issn>1863-2661</issn><issn>0340-2061</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kE1LwzAch4MoOqdfwIMEvHip5qVpk6MM32CgB_Ua0vTf0ZE2M2mRfXszNxU8GAgJ5Pn9kjwInVFyRQkpryMhOVMZYWQzS5qRPTShsuAZKwq6_7MX_Agdx7gkRChJ1SE64oznjDExQW_PEKLvjWuHNW6MHXyI2PQ1thCgCsbhhRutj4A7GEzlXRs73PbY-q4b-xTK6g9wru0X2LsaAjb16IZ4gg4a4yKc7tYper27fZk9ZPOn-8fZzTyzvBRDJqThQFluTKkKyypo8qK0nBcgqzRYZaqaKyJ4Y5WQsill1VCoZd3YXAIt-RRdbntXwb-PEAfdtdGmB5ke_Bg140oURAjFEnrxB136MaSfJyqnNOdUUZkotqVs8DEGaPQqtJ0Ja02J3ljXW-s6Gddf1jVJofNd9Vh1UP9EvjUngG-BmI76BYTfu_-p_QQYBY4b</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Sohrabi, Hamid R.</creator><creator>Goozee, Kathryn</creator><creator>Weinborn, Michael</creator><creator>Shen, Kaikai</creator><creator>Brown, Belinda M.</creator><creator>Rainey-Smith, Stephanie R.</creator><creator>Salvado, Olivier</creator><creator>Taddei, Kevin</creator><creator>Bucks, Romola S.</creator><creator>Maruff, Paul</creator><creator>Laws, Simon M.</creator><creator>Lenzo, Nat</creator><creator>Laws, Manja</creator><creator>DeYoung, Colin</creator><creator>Speelman, Craig</creator><creator>Laske, Christoph</creator><creator>Ames, David</creator><creator>Savage, Greg</creator><creator>Martins, Ralph N.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8017-8682</orcidid></search><sort><creationdate>20200601</creationdate><title>Personality factors and cerebral glucose metabolism in community-dwelling older adults</title><author>Sohrabi, Hamid R. ; Goozee, Kathryn ; Weinborn, Michael ; Shen, Kaikai ; Brown, Belinda M. ; Rainey-Smith, Stephanie R. ; Salvado, Olivier ; Taddei, Kevin ; Bucks, Romola S. ; Maruff, Paul ; Laws, Simon M. ; Lenzo, Nat ; Laws, Manja ; DeYoung, Colin ; Speelman, Craig ; Laske, Christoph ; Ames, David ; Savage, Greg ; Martins, Ralph N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-58a3e124aa796c2bef467c336e8bbbb2babd39053fc9588f78bf1ed8dfc48e173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer's disease</topic><topic>Apolipoprotein E</topic><topic>Apolipoprotein E4 - genetics</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain research</topic><topic>Cell Biology</topic><topic>Cerebral Cortex - metabolism</topic><topic>Clinical significance</topic><topic>Cognitive ability</topic><topic>Cortex (entorhinal)</topic><topic>Cross-Sectional Studies</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Female</topic><topic>Genotype</topic><topic>Glucose</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Independent Living</topic><topic>Male</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Neocortex</topic><topic>Neurodegenerative diseases</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Neurosis</topic><topic>Older people</topic><topic>Original Article</topic><topic>Personality</topic><topic>Personality - physiology</topic><topic>Personality Tests</topic><topic>Positron emission tomography</topic><topic>Tau protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sohrabi, Hamid R.</creatorcontrib><creatorcontrib>Goozee, Kathryn</creatorcontrib><creatorcontrib>Weinborn, Michael</creatorcontrib><creatorcontrib>Shen, Kaikai</creatorcontrib><creatorcontrib>Brown, Belinda M.</creatorcontrib><creatorcontrib>Rainey-Smith, Stephanie R.</creatorcontrib><creatorcontrib>Salvado, Olivier</creatorcontrib><creatorcontrib>Taddei, Kevin</creatorcontrib><creatorcontrib>Bucks, Romola S.</creatorcontrib><creatorcontrib>Maruff, Paul</creatorcontrib><creatorcontrib>Laws, Simon M.</creatorcontrib><creatorcontrib>Lenzo, Nat</creatorcontrib><creatorcontrib>Laws, Manja</creatorcontrib><creatorcontrib>DeYoung, Colin</creatorcontrib><creatorcontrib>Speelman, Craig</creatorcontrib><creatorcontrib>Laske, Christoph</creatorcontrib><creatorcontrib>Ames, David</creatorcontrib><creatorcontrib>Savage, Greg</creatorcontrib><creatorcontrib>Martins, Ralph N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest Biological Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Brain Structure and Function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sohrabi, Hamid R.</au><au>Goozee, Kathryn</au><au>Weinborn, Michael</au><au>Shen, Kaikai</au><au>Brown, Belinda M.</au><au>Rainey-Smith, Stephanie R.</au><au>Salvado, Olivier</au><au>Taddei, Kevin</au><au>Bucks, Romola S.</au><au>Maruff, Paul</au><au>Laws, Simon M.</au><au>Lenzo, Nat</au><au>Laws, Manja</au><au>DeYoung, Colin</au><au>Speelman, Craig</au><au>Laske, Christoph</au><au>Ames, David</au><au>Savage, Greg</au><au>Martins, Ralph N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Personality factors and cerebral glucose metabolism in community-dwelling older adults</atitle><jtitle>Brain Structure and Function</jtitle><stitle>Brain Struct Funct</stitle><addtitle>Brain Struct Funct</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>225</volume><issue>5</issue><spage>1511</spage><epage>1522</epage><pages>1511-1522</pages><issn>1863-2653</issn><eissn>1863-2661</eissn><eissn>0340-2061</eissn><abstract>Personality factors have been associated with Alzheimer’s disease (AD) and dementia, but they have not been examined against markers of regional brain glucose metabolism (a primary measure of brain functioning) in older adults without clinically diagnosed cognitive impairment. The relationship between personality factors derived from the five-factor model and cerebral glucose metabolism determined using positron emission tomography (PET) with [18F]-2-fluoro-2-deoxy-
d
-glucose (18F-FDG-PET) was examined in a cohort of 237 non-demented, community-dwelling older adults aged 60–89 years (M ± SD = 73.76 ± 6.73). Higher neuroticism and lower scores on extraversion and conscientiousness were significantly associated with decreased glucose metabolism in brain regions typically affected by AD neuropathological processes, including the hippocampus and entorhinal cortex. Furthermore, while there were significant differences between apolipoprotein E (
APOE
) ε4 allele carriers and non-carriers on
18
F-FDG-PET results in the neocortex and other brain regions (
p
< 0.05), there was no significant difference between carriers and non-carriers on personality factors and no significant interactions were found between
APOE
ε4 carriage and personality factors on brain glucose metabolism. In conclusion, we found significant relationships between personality factors and glucose metabolism in neural regions more susceptible to AD neuropathology in older adults without clinically significant cognitive impairment. These findings support the need for longitudinal research into the potential mechanisms underlying the relationship between personality and dementia risk, including measurement of change in other AD biomarkers (amyloid and tau imaging) and how they correspond to change in personality factors. Future research is also warranted to determine whether timely psychological interventions aimed at personality facets (specific aspects or characteristics of personality factors) can affect imaging or other biomarkers of AD resulting in delay or ideally preventing the onset of the cognitive impairment.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32342225</pmid><doi>10.1007/s00429-020-02071-0</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-8017-8682</orcidid></addata></record> |
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| ispartof | Brain Structure and Function, 2020-06, Vol.225 (5), p.1511-1522 |
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| subjects | Aged Aged, 80 and over Alzheimer's disease Apolipoprotein E Apolipoprotein E4 - genetics Biomarkers Biomedical and Life Sciences Biomedicine Brain research Cell Biology Cerebral Cortex - metabolism Clinical significance Cognitive ability Cortex (entorhinal) Cross-Sectional Studies Dementia Dementia disorders Female Genotype Glucose Glucose - metabolism Humans Independent Living Male Metabolism Middle Aged Neocortex Neurodegenerative diseases Neuroimaging Neurology Neurosciences Neurosis Older people Original Article Personality Personality - physiology Personality Tests Positron emission tomography Tau protein |
| title | Personality factors and cerebral glucose metabolism in community-dwelling older adults |
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